High levels of circulating extracellular vesicles with altered expression and function during pregnancy

Nardi, Fabiola da Silva; Michelon, Tatiana; Neumann, Jorge; Manvailer, Luis Felipe Santos; Wagner, Bettina; Horn, Peter A.; Bicalho, Maria da Graça; Rebmann, Vera

doi:10.1016/j.imbio.2016.03.001

Cited by 31 publications

(19 citation statements)

References 49 publications

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“…Several studies have evaluated the concentrations and origins of circulating EVs in the maternal system and elucidated their ability to interact with the immune cells and regulate them [28,57,71,82]. Remarkably, pregnancy is characterized by higher levels of circulating EVs than non-pregnant state and they progressively increase with gestational age, achieving highest concentration in the third trimester [65,71,79]. During early stages of pregnancy, EVs derived from endometrium, embryo, and trophoblast cells can influence the maternal immune response, whereas towards the advanced stages of gestation, the EVs released by the placenta, mainly STB-derived EVs, are the key players (reviewed in [94]).…”

Section: Evs In Pregnancy and Their Effects On Maternal Immune Systemmentioning

confidence: 99%

“…Placental exosome possesses a distinct protein profile and more potent anti-viral activity compared to other placental EVs [27] In vivo (in mice) Differential ultracentrifugation EM Circulating exosomes in pregnancy suppress T cell activation [65] Plasma/serum ExoQuick™ (System Biosciences) NTA, WB for Hsp70, ICAM-1, CD9, CD63, CD81,and TSG101…”

Section: Immunomodulatory Role Of Evs In Pathological Pregnanciesmentioning

confidence: 99%

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Extracellular vesicles and their immunomodulatory functions in pregnancy

Nair

Salomón

2018

Semin Immunopathol

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Extracellular vesicles (EVs) are membrane-bound vesicles released into the extracellular space by almost all types of cells. EVs can cross the physiological barriers, and a variety of biological fluids are enriched in them. EVs are a heterogeneous population of vesicles, including exosomes, microvesicles, and apoptotic bodies. The different subpopulations of vesicles can be differentiated by size and origin, in which exosomes (~100 nm and from endocytic origin) are the most studied so far. EVs have essential roles in cell-to-cell communication and are critical modulators of immune response under normal and pathological conditions. Pregnancy is a unique situation of immune-modulation in which the maternal immune system protects the fetus from allogenic rejection and maintains the immunosurveillance. The placenta is a vital organ that performs a multitude of functions to support the pregnancy. The EVs derived from the human placenta have crucial roles in regulating the maternal immune response for successful pregnancy outcome. Placenta-derived vesicles perform a myriad of functions like suppression of immune reaction to the developing fetus and establishment and maintenance of a systemic inflammatory response to combat infectious intruders. A fine-tuning of these mechanisms is quintessential for successful completion of pregnancy and healthy outcome for mother and fetus. Dysregulation in the mechanisms mentioned above can lead to several pregnancy disorders. In this review, we summarize the current literature regarding the critical roles played by the EVs in immunomodulation during pregnancy with particular attention to the placenta-derived exosomes.

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Section: Evs In Pregnancy and Their Effects On Maternal Immune Systemmentioning

confidence: 99%

Section: Immunomodulatory Role Of Evs In Pathological Pregnanciesmentioning

confidence: 99%

Extracellular vesicles and their immunomodulatory functions in pregnancy

Nair

Salomón

2018

Semin Immunopathol

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“…EV have biological functions linked to sperm maturation and motility, follicular growth, oocyte meiosis, steroidogenesis, and the prevention of polyspermy after fertilization. In the uterus, EV mediate the crosstalk between embryo and endometrium during implantation [40] and are crucial regulators throughout pregnancy [41,42]. …”

Section: Micro-intro To the Microrna Worldmentioning

confidence: 99%

Roles of MicroRNA across Prenatal and Postnatal Periods

Floris

Kraft

Altosaar

2016

IJMS

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Communication between mother and offspring in mammals starts at implantation via the maternal–placental–fetal axis, and continues postpartum via milk targeted to the intestinal mucosa. MicroRNAs (miRNAs), short, noncoding single-stranded RNAs, of about 22 nucleotides in length, are actively involved in many developmental and physiological processes. Here we highlight the role of miRNA in the dynamic signaling that guides infant development, starting from implantation of conceptus and persisting through the prenatal and postnatal periods. miRNAs in body fluids, particularly in amniotic fluid, umbilical cord blood, and breast milk may offer new opportunities to investigate physiological and/or pathological molecular mechanisms that portend to open novel research avenues for the identification of noninvasive biomarkers.

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“…The size as well as size distribution, and the concentration of individual subpopulations of vesicles (exosomes and microvesicles) is commonly determined by Nanotracking Analysis (NTA), and Zetaview [141][142][143][144][145][146][147][148], and tunable resistive pulse sensing (qNANO) [149]. The electron microscopy is used to assess the submicron phenotype of vesicles [139,147,[150][151][152],…”

Section: Characterization Of Extracellular Vesiclesmentioning

confidence: 99%

Estudo sobre as respostas inflamatórias em modelo experimental de artrite séptica induzida por Staphylococcus aureus e suas vesículas

Fatima¹

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I would like to express my profound gratitude to all those who helped me in different ways during my PhD. In particular I am rather indebted to thank; Luciano Neder: PhD supervisor, for giving me the opportunity to work in his group. His kind supervision, guidance, and allowing me to work at my own pace and comfort made this submission possible. The biggest appreciation is the opportunity he gave me to have a work-life balance, allowing me to take decision that are suitable for my scenarios that allowed me complete mental strength and peace to fulfil my work efficiently. I will ever be thankful for all this. Tao Jin: my co-supervisor, who proved to be one of the productive additions in my scientific career. It was a great experience being at Gothenburg and exploring new areas of research in his lab at Sahlgrenska Academy. He provided me with great lab facilities along with complete independence and confidence to work independently on new projects. His friendly way of mentoring will always leave a mark on my future research career. Alfredo Ribeiro da Silva and other members of the postgraduate program of department of pathology: for making things easy going, documentations and related matters at the department. Many thanks to my lab colleagues both in Brazil and Sweden; Bruna Zanetti, Niele Dias Mendes, Renata Silvestre, Nathalia and Isabela, Deise, Anabelle, Abukar, Manli, Fei and Majd for their pleasant company and assistance during my research work as well as facilitating my stay in the lab. Camila Zambonini: Thank you so much for administrative help during all my time at this department. It was all hard to complete PhD. I also thank Felipe Denipotte Coelho, Rodrigo Banzi, Rosangela, Neide Terezinha and Antonio de Padua for helping me in several ways. Yes, that IT expert guy: every time appears with a whistle and solves the technical issues. Finally, my deepest gratitude goes to my parents for unconditional love and support throughout my life. Their hard work and dedication made me able to achieve what I seek today. Unfortunately they left too soon to see that there efforts no doubt made me stand where I am today. Their uncountable prayers have, and will always lighten my paths. May they rest in the highest place of Jannah (Heaven). Ameen. Muhammad Umer, my only brother, my first friend and my mentor and role model in every aspect of life. The space you left can never be filled. My sisters Nadia Haroon, Aisha Jaudat and Madiha Aslam for the continous support, friendly chats and unconditional love, my brother in laws Haroon Jamil, Jaudat Fayyazi and Shehzad Aslam for their prayers, wishes and support and my little group of loud and fun gang, my nephews Abdur rehman Haroon, Rayyan Aslam, Fahad Haroon and Muhammad Azlan and our lovely princess Aidha Jaudat for the fun times, treats and lovely bonding. Moreover, I extend special thanks to my in-laws for their continuous prayers and wishes for my success in life. May Allah keep my whole family and relatives, healthy and place them among His loved ones. Ameen Last bu...

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High levels of circulating extracellular vesicles with altered expression and function during pregnancy

Cited by 31 publications

References 49 publications

Extracellular vesicles and their immunomodulatory functions in pregnancy

Extracellular vesicles and their immunomodulatory functions in pregnancy

Roles of MicroRNA across Prenatal and Postnatal Periods

Estudo sobre as respostas inflamatórias em modelo experimental de artrite séptica induzida por Staphylococcus aureus e suas vesículas

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