High Levels of IgM Antibodies Specific for<i>Toxoplasma gondii</i>in Pregnancy 12 Years after Primary Toxoplasma Infection

Bobić, Branko; Sibalić, D; Djurković–Djaković, Olgica

doi:10.1159/000293151

Cited by 79 publications

(12 citation statements)

References 2 publications

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“…Study conducted in Kashmir by Zargar et al [ 20 ] in 1998 revealed the prevalence of IgM anti- Toxoplasma antibody in women with recurrent abortion (49.47%), which was more than the control group with normal delivery (8.88%); they suggested a probable relationship between Toxoplasma infection and recurrent abortion. Bobic et al [ 21 ] in 1991 showed that the prevalence of IgG and IgM antibodies in women with uncomplicated abortion is 44.9% and 33.3%, respectively.…”

Section: Resultsmentioning

confidence: 99%

Seroprevalence of Toxoplasma gondii in Women Who Have Aborted in Comparison with the Women with Normal Delivery in Ahvaz, Southwest of Iran

Saki

Mohammadpour

Moramezi

et al. 2015

The Scientific World Journal

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Toxoplasma gondii is an obligate intracellular protozoan parasite causing toxoplasmosis in animals and humans. Primary maternal infection with toxoplasmosis during pregnancy is frequently associated with transplacental transmission to the fetus. However it is not certain whether Toxoplasma infection can cause recurrent abortion. The aim of this study was to determine the relationship between Toxoplasma infection and abortion via detection of anti-Toxoplasma gondii antibodies in sera of women with obstetrical problems and compare the results with control group consisting of women with history of normal delivery. Sera from 130 women with abortion and sera of 130 women with normal delivery were tested for IgG and IgM anti-Toxoplasma gondii antibodies by ELISA method. The present study revealed 24.6% of the samples with abortion and 21.5% of the samples with normal delivery were positive for IgG antibodies. However, statistical analysis indicated no significant differences (P > 0.05). In addition, IgM antibody was detected in one woman who had aborted but not in women with normal childbirth. This study showed no significant difference between the case and control groups in IgG anti-Toxoplasma antibody but detected one sample with IgM antibodies in woman with abortion during the first trimester of pregnancy. In order to determine the relationship between Toxoplasma infection and abortion, anti-Toxoplasma IgG avidity and PCR to discriminate between recent and prior infections are recommended.

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Section: Resultsmentioning

confidence: 99%

Seroprevalence of Toxoplasma gondii in Women Who Have Aborted in Comparison with the Women with Normal Delivery in Ahvaz, Southwest of Iran

Saki

Mohammadpour

Moramezi

et al. 2015

The Scientific World Journal

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“…Forty-three women of childbearing age (5.2%) tested positive for anti- T. gondii IgM antibody. If they were pregnant, IgG avidity testing is the preferred method to confirm recent infection,34 because IgM antibodies can persist for months after initial infection in some individuals 35,36. Alternate testing algorithms use higher IgM serologic titers as good indicators of acute infection when economic considerations preempt additional tests 37,38…”

Section: Discussionmentioning

confidence: 99%

Toxoplasma gondii Seropositivity and Co-Infection with TORCH Pathogens in High-Risk Patients from Qatar

Abu-Madi¹,

Behnke²,

Dabritz³

2010

The American Society of Tropical Medicine and Hygiene

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Testing of patients who are deemed to be at high risk for TORCH pathogens, e.g., pregnant women, their fetuses, neonates, and acquired immunodeficiency syndrome (AIDS) patients, is important so that specific treatment can be initiated. This study included 1,857 such patients between 2005 and 2008. Logistic regression was used to evaluate factors associated with Toxoplasma gondii seropositivity. Among 823 women of childbearing age, 35.1% and 5.2% tested positive for T. gondii IgG and IgM, respectively. Three infants ≤ 6 months of age (0.8% of 353) were congenitally infected. Factors associated with T. gondii IgG seropositivity included older age, East Mediterranean or African nationality, positive cytomegalovirus (CMV) and herpes simplex virus (HSV)-1 serostatus, and negative rubella IgG results. The decreasing prevalence of IgM antibodies between 2005 and 2008 suggested that exposure to T. gondii from food or environmental sources declined over this period in Qatar. Population-based studies of newborns would be helpful to accurately estimate incidence of congenital toxoplasmosis.

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“…The presence of anti- T. gondii IgG antibodies implies the parasite infection, but gives no information on infection time; anti- T. gondii IgM is not an accurate marker of acute infection [ 94 – 96 ], nor is IgA a specific marker of the acute phase [ 97 ]. The IgG avidity test, first described by Hedman et al [ 98 ], is now widely used to differentiate between acute and chronic T. gondii infections [ 99 ].…”

Section: Reviewmentioning

confidence: 99%

Diagnosis of toxoplasmosis and typing of Toxoplasma gondii

et al. 2015

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Toxoplasmosis, caused by the obligate intracellular protozoan Toxoplasma gondii, is an important zoonosis with medical and veterinary importance worldwide. The disease is mainly contracted by ingesting undercooked or raw meat containing viable tissue cysts, or by ingesting food or water contaminated with oocysts. The diagnosis and genetic characterization of T. gondii infection is crucial for the surveillance, prevention and control of toxoplasmosis. Traditional approaches for the diagnosis of toxoplasmosis include etiological, immunological and imaging techniques. Diagnosis of toxoplasmosis has been improved by the emergence of molecular technologies to amplify parasite nucleic acids. Among these, polymerase chain reaction (PCR)-based molecular techniques have been useful for the genetic characterization of T. gondii. Serotyping methods based on polymorphic polypeptides have the potential to become the choice for typing T. gondii in humans and animals. In this review, we summarize conventional non-DNA-based diagnostic methods, and the DNA-based molecular techniques for the diagnosis and genetic characterization of T. gondii. These techniques have provided foundations for further development of more effective and accurate detection of T. gondii infection. These advances will contribute to an improved understanding of the epidemiology, prevention and control of toxoplasmosis.

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High Levels of IgM Antibodies Specific forToxoplasma gondiiin Pregnancy 12 Years after Primary Toxoplasma Infection

Cited by 79 publications

References 2 publications

Seroprevalence of Toxoplasma gondii in Women Who Have Aborted in Comparison with the Women with Normal Delivery in Ahvaz, Southwest of Iran

Seroprevalence of Toxoplasma gondii in Women Who Have Aborted in Comparison with the Women with Normal Delivery in Ahvaz, Southwest of Iran

Toxoplasma gondii Seropositivity and Co-Infection with TORCH Pathogens in High-Risk Patients from Qatar

Diagnosis of toxoplasmosis and typing of Toxoplasma gondii

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