High Levels Of Interleukin-10 During The Initial Phase Of Fulminant Meningococcal Septic Shock

Abstract

Interleukin (IL)-10 has an important antiinflammatory effect by inhibiting endotoxin-induced production of proinflammatory cytokines, such as tumor necrosis factor-alpha and IL-1. Since both cytokines are produced in massive amounts during fulminant meningococcal septic shock and are associated with severity of disease, IL-10 was measured in plasma samples of 25 consecutive children with fulminant meningococcal septic shock shortly after admittance to a pediatric intensive care unit. High levels of IL-10 (median, 6021 pg/mL; range, 137-24,600) were found in surviving patients (median, 1268 pg/mL; range, 137-24,600) and in those who died (median, 9915 pg/mL; range, 3996-14,100). IL-10 levels correlated weakly (r = .38; P = .055) with severity of disease as measured by the Glasgow meningococcal septicemia prognostic score. The findings indicate that IL-10 is produced in massive amounts in the initial phase of fulminant meningococcal septic shock.

Differential regulation of interleukin-10 production by genetic and environmental factors – a twin study

“…4 IL-10 has a central role in the pathogenesis of autoimmune diseases like systemic lupus erythematosus (SLE) 5 and influences susceptibility and the course of various infectious diseases. [6][7][8] The constitutive expression of IL-10 in monocytes and lymphocytes is low. 9 IL-10 production is mostly regulated at the transcriptional level.…”

Methylprednisolone differentially regulates IL-10 and tumour necrosis factor (TNF) production during murine endotoxaemia

“…rIL-10 inhibits the production of inflammatory cytokines, including TNF, by LPS-activated monocytes/ macrophages and protects mice from LPS-induced lethality [10,11]. Endogenous IL-10 is produced in patients with various inflammatory disorders, including septic shock [12][13][14], malaria [15], rheumatoid arthritis [16] and in animal models of septic shock including endotoxin shock and septic peritonitis [17][18][19].…”

Interleukin 12 Levels During the Initial Phase of Septic Shock With Purpura in Children: Relation to Severity of Disease

“…Lipopolysaccharide (LPS) released from Gram-negative bacteria such as meningococci initiate the production of pro-inflammatory cytokines by cells of the mononuclear-macrophage lineage and endothelial cells. Circulating levels of these cytokines, including tumor necrosis factor (TNF)-a, interleukin (IL)-1, 1 IL-6, 1,2 IL-8, 3 and IL-10, 4,5 are increased in children with septic shock and purpura. Severity of disease is related to the initial plasma levels of LPS 6 and of these cytokines.…”