High levels of mineralocorticoids in preovulatory follicular fluid could contribute to oocyte development

Sneeringer, R.M.; Penzias, Alan S.; Barrett, Brent; Usheva, Anny

doi:10.1016/j.fertnstert.2010.06.028

Cited by 18 publications

(16 citation statements)

References 40 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…ANG also stimulates vascular proliferation around the follicular antrum. In laboratory animals and human beings, after the peak of luteinizing hormone (LH), ANG modulates blood flow to the follicles for ovulation and maturation (Sneeringer et al 2011).…”

mentioning

confidence: 99%

“…It is currently unknown whether mares also present an activation of this system during the estrous cycle. As described before, the RAAS during the estrous cycle has been thoroughly evaluated in primates and non-primate animals and women (Harewood et al 1996;Chapman et al 1997;Chidambaram et al 2002;Szmuilowicz et al 2006;Sneeringer et al 2011), but not in mares.…”

mentioning

confidence: 99%

See 1 more Smart Citation

Activation of the renin-angiotensin-aldosterone system in mares around ovulation

Satué¹,

Montesinos²,

Munos³

2017

CZECH J ANIM SCI

View full text Add to dashboard Cite

Satué K., Montesinos P., Muños A. (2017): Activation of the renin-angiotensin-aldosterone system in mares around ovulation. Czech J. Anim. Sci., 62,[259][260][261][262][263][264][265][266][267] Many physiological events occurring during the estrous cycle, including folliculogenesis, oocyte maturation, ovulation, follicular atresia, corpus luteum development, luteolysis, steroidogenesis, and angiogenesis are associated with an increased expression of the renin-angiotensin-aldosterone system (RAAS) in uterus and ovarian follicles. This enhanced expression leads to a rise in plasma concentrations of these hormones in women and laboratory animals, and the same might happen in the mare. This study aims to assess if an activation of the RAAS occurs in mares around ovulation and if this activation is related to the diameter of the predominant follicle (DPF), packed cell volume (PCV), and electrolyte concentrations. Twenty-five healthy Spanish Purebred mares were sampled during the five days before ovulation, the day of ovulation, and the first five days after ovulation. Renin (REN) concentrations increased progressively during the five days before ovulation, achieving the highest values on the day of ovulation. Angiotensin (ANG) concentrations showed a sharp decrease after ovulation, with the lowest values the fifth day after it. Aldosterone (ALD) concentrations increased progressively, from the fifth day before ovulation until the fifth day after ovulation. The highest PCV values were found on the day of ovulation. There were no relevant correlations between the RAAS components and electrolytes concentrations. Before ovulation, there was a positive relationship between REN and ALD (r = 0.760) and after ovulation, a negative correlation between ANG and ALD (r = -0.660). The DPF was correlated with REN (r = 0.740) and with ALD (r = 0.800) concentrations. Ovulation in the mare is associated with high plasma REN concentrations, and therefore, with an activation of the RAAS. In addition, after ovulation, the sharp decrease in plasma REN and ANG concentrations might be a reflex of the modulation of the previously activated RAAS, although plasma ALD concentrations increased during this period.

show abstract

mentioning

confidence: 99%

mentioning

confidence: 99%

Activation of the renin-angiotensin-aldosterone system in mares around ovulation

Satué¹,

Montesinos²,

Munos³

2017

CZECH J ANIM SCI

View full text Add to dashboard Cite

show abstract

“…Also, human pre-ovulatory follicles were shown to contain high concentrations of aldosterone in the follicular fluid [121]. Granulosa cell gene expression that promotes aldosterone production and accumulation of corticosterone were also noted to be increased in younger women [121] and might aid in the identification of mature oocytes ready for ovulation. The findings could suggest the relevance of the ovarian rennin-angiotensin system in ovulation.…”

Section: Bio-molecules In the Gonadotrophin Dependent Phase Of Follicmentioning

confidence: 99%

Biomolecules of Human Female Fertility - Potential Therapeutic Targets for Pharmaceutical Design

Huang¹,

Fragouli²,

Wells³

2012

CPD

View full text Add to dashboard Cite

Scientists are able to advance the frontiers of human reproduction by employing a variety of molecular biological techniques to understand the biological processes intricately linked to oocyte and ovarian follicle development. Despite an abundance of knowledge concerning essential pathways which may have critical roles in oogenesis and folliculogenesis, the repertoire of medications to treat female fertility problems remains limited to a few classes of drugs involved in the induction or suppression of folliculogenesis and ovulation; many of which are not specific in their drug actions and can give rise to complications during clinical application. This paper aims to review biomolecules and pathways (e.g. PI3K, WNT, MAPK) pertinent to ovarian follicular development and active in human oocytes, including those involved in communication between somatic cells within the ovary (cumulus cells, granulosa cells and thecal cells) and the oocyte itself. These biomolecules which are involved in the nuclear and cytoplasmic maturation of oocytes and the control of ovarian folliculogenesis have potential as targets for improved ovarian stimulation, optimisation of oocyte maturation, and as biomarkers of oocyte viability assessment.

show abstract

“…In addition, luteinized GC have been shown to express CYP21A2 [13]. In addition, the presence of the mineralocorticoid receptor (NR3C2) has been reported in the ovary of rats [14,15], macaques [10], cattle [16], and humans [12,13]. Altogether, these results indicate that the ovary is constantly exposed to circulating and possibly locally synthesized mineralocorticoids.…”

mentioning

confidence: 92%

“…In cattle, GC and theca cells were shown to express functional CYP11B1 [11]. In humans, concentrations of Aldo and its precursor corticosterone in preovulatory follicles stimulated by an ovulatory dose of hCG are higher than those in the plasma [12]. In addition, luteinized GC have been shown to express CYP21A2 [13].…”

mentioning

confidence: 99%

Expression of genes encoding mineralocorticoid biosynthetic enzymes and the mineralocorticoid receptor, and levels of mineralocorticoids in the bovine follicle and corpus luteum

Mukangwa

Takizawa

Aoki

et al. 2020

Journal of Reproduction and Development

View full text Add to dashboard Cite

Unlike sex steroids, mineralocorticoids have attracted limited attention in ovarian physiology. Recent studies on primates have indicated possible local synthesis and action of mineralocorticoids in the ovary. Here, we examined developmental changes in the levels of mineralocorticoids and expression of genes encoding their biosynthetic enzymes and receptor in the bovine ovary. The follicles and corpora lutea (CL) were collected from F1 heifers. Expression levels of 21α-hydroxylase (CYP21A2), 11β-hydroxylase-1 (CYP11B1), and the mineralocorticoid receptor (NR3C2) in granulosa cells (GC), thecal layers (TL), and CL tissues were quantified by real-time PCR, whereas mineralocorticoids in the follicular fluid were measured by enzyme immunoassay (EIA). TL and GC expressed CYP21A2 and NR3C2, whereas CYP11B1 was expressed at very low or undetectable levels. The expression levels of these genes were not significantly different among small/large and healthy/atretic follicles but were higher in TL than in GC. CYP21A2 and NR3C2 were expressed in all CL stages with higher expression observed in the mid-stage. CYP11B1 expression was only apparent in the mid-stage CL. Aldosterone was detected in all follicles, and its concentration was not significantly different among the follicular groups. In paired large-healthy/atretic follicles, the concentration of deoxycorticosterone, a precursor of aldosterone, was approximately ten-fold higher than that of aldosterone and not significantly different between healthy and atretic follicles. In conclusion, the presence of mineralocorticoids and expression of NR3C2 in the bovine follicle together with the developmental change in the expression of CYP21A2, CYP11B1, and NR3C2 in the CL suggest possible endocrine/paracrine/autocrine roles of mineralocorticoids in the bovine ovary.

show abstract

High levels of mineralocorticoids in preovulatory follicular fluid could contribute to oocyte development

Cited by 18 publications

References 40 publications

Activation of the renin-angiotensin-aldosterone system in mares around ovulation

Activation of the renin-angiotensin-aldosterone system in mares around ovulation

Biomolecules of Human Female Fertility - Potential Therapeutic Targets for Pharmaceutical Design

Expression of genes encoding mineralocorticoid biosynthetic enzymes and the mineralocorticoid receptor, and levels of mineralocorticoids in the bovine follicle and corpus luteum

Contact Info

Product

Resources

About