1993
DOI: 10.1038/bjc.1993.345
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High levels of Nm23 gene expression in advanced stage of thyroid carcinomas

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Cited by 75 publications
(46 citation statements)
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“…Our results also confirm the presence of other proteins previously associated with follicular-derived thyroid neoplasia, including nucleoside diphosphate kinase 1 (also known as nm23-H1), the nm23 metastatic suppressor gene product. Published mRNA and immunohistochemical studies suggest that the level of expression of nm23-H1 might be useful as a prognostic marker, especially for FTC and, less so, for PTC (20)(21)(22). Notably, because the present study compared two types of follicular neoplasia, we did not find galectin 3 nor cytokeratin 19, both known markers for PTC.…”
Section: Discussioncontrasting
confidence: 43%
“…Our results also confirm the presence of other proteins previously associated with follicular-derived thyroid neoplasia, including nucleoside diphosphate kinase 1 (also known as nm23-H1), the nm23 metastatic suppressor gene product. Published mRNA and immunohistochemical studies suggest that the level of expression of nm23-H1 might be useful as a prognostic marker, especially for FTC and, less so, for PTC (20)(21)(22). Notably, because the present study compared two types of follicular neoplasia, we did not find galectin 3 nor cytokeratin 19, both known markers for PTC.…”
Section: Discussioncontrasting
confidence: 43%
“…The Nm23-HI and Nm23-H2 genes have been shown to be identical to the human NDP kinase A and B chains respectively (Gilles et al, 1991). Several studies (Belivacqua et al, 1989;Barnes et al, 1991;Hennessey et al, 1991;Hirayama et al, 1991;Royds et al, 1993) (Florenes et al, 1992) and the presence of hepatoceliular carcinoma metastases (Nakayama et al, 1992), incresed Nm23 expression has been associated with a decrease in squamous cell lung cancer (Engel et al, 1993) and neuroblastoma (Hailat et al, 1991;Leone et al, 1993) disease-free survival as well as with advanced (anaplastic) thyroid cancer stages (Zou et al, 1993). However, other studies have shown that increased Nm23 expression in lung (Higashiyama et al, 1992) in the non-metastatic lesions (Wang et al, 1993).…”
mentioning
confidence: 99%
“…Similarly, it has been indicated an association of nm23 overexpression with a larger tumour in neuroblastoma, thyroid, gastric and renal cell carcinomas (Hailat et al, 1991;Zou et al, 1993;Park et al, 1995;Müller et al, 1998). Increasing evidences have suggested that nm23 be (Igawa et al, 1994;Caligo et al, 1995).…”
Section: Discussionmentioning
confidence: 90%
“…Cipollini et al (1997) also reported that downregulation of nm23 gene inhibited cell proliferation. However, not all of the above studies demonstrated a negative prognostic impact of nm23 overexpression or late T stage tumours (Zou et al, 1993;Müller et al, 1998). There were also some discrepancies among previous studies of the same tumours, such as gastric and colorectal cancers (Cohn et al, 1991;Haut et al, 1991;Kodera et al, 1994;Müller et al, 1998).…”
Section: Discussionmentioning
confidence: 99%
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