High levels of Von Willebrand factor markers in COVID-19: a systematic review and meta-analysis

Rostami, Mehrdad; Mansouritorghabeh, Hassan; Parsa-Kondelaji, Mohammad

doi:10.1007/s10238-021-00769-x

Cited by 33 publications

(29 citation statements)

References 59 publications

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“…SARS‐CoV‐2 infection of these cells may lead to the development of endotheliitis, systemic vasculitis and disseminated intravascular coagulation (DIC) [71]. This may also explain the high frequency of thrombosis and thromboembolism has been also reported in COVID‐19 patients [72].…”

Section: Vasculitis As Potential Cause Of Orchitis‐like Syndromementioning

confidence: 99%

Could SARS‐CoV‐2 infection affect male fertility and sexuality?

Muti

Finocchi

Tossetta

et al. 2022

APMIS

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Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the cause of coronavirus infectious disease (COVID-19) and has rapidly spread worldwide, causing serious problems to the healthcare systems of many countries and hundreds of thousand deaths. In this review we discuss data from the literature to understand whether the various districts of the male reproductive system may represent another vulnerable target for SARS-CoV-2. Studies were searched from electronic databases such as Google Scholar, PubMed, Scopus, and COVID-19 specific databases such as LitCovid, until July 31, 2021. It appears that SARS-CoV-2 virus infection not only causes damage to the respiratory system, but could have a serious impact on the reproductive system of male patients modulating many physiological processes. Like some other infections, SARS-CoV-2 also leads to a worsening of semen quality and an increase in oxidative stress (OS) levels. However, due to the limited number of studies, it is unclear whether this deterioration in semen parameters is temporary or lasts over time. It is certainly important that patients' reproductive function is monitored after coronavirus infection to avoid problems in reproductive health in the future.

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Section: Vasculitis As Potential Cause Of Orchitis‐like Syndromementioning

confidence: 99%

Could SARS‐CoV‐2 infection affect male fertility and sexuality?

Muti

Finocchi

Tossetta

et al. 2022

APMIS

View full text Add to dashboard Cite

show abstract

“…A low ADAMTS13/VWF ratio has been an independent indicator of COVID-19 severity apart from complement activation [ 12 – 14 ]. Whereas, amplification of AP activation is a phenomenon lately recognized in congenital deficiency of ADAMTS13 activity [ 15 , 16 ].…”

Section: Discussionmentioning

confidence: 99%

“…Beyond this period, these patients exhibit either the early- or late-onset phenotype of TTP bouts [ 99 , 100 ]. In both, however, there is often severe renal dysfunction during the acute phase [ 14 – 16 ]. Kidney biopsies revealed deposits of complement C3 and C5b-9 in the renal cortex [ 14 ].…”

Section: Activation and Amplification Of The Alternative Complement P...mentioning

confidence: 99%

“…In both, however, there is often severe renal dysfunction during the acute phase [ 14 – 16 ]. Kidney biopsies revealed deposits of complement C3 and C5b-9 in the renal cortex [ 14 ]. Moreover, in these patients, the plasma level of sC5b-9 was remarkably increased during the acute phase [ 15 ], even without the accompanying gene mutations of complement and its regulatory factors responsible for atypical HUS [ 16 , 17 ], while ex vivo assays showed that patient serum induced C3 and C5b-9 deposits on cultured vascular ECs.…”

Section: Activation and Amplification Of The Alternative Complement P...mentioning

confidence: 99%

“…In fact, in COVID-19 patients, complement activation generates tissue factor (TF)-enriched neutrophil extracellular traps (NETs), which mediate both thrombosis and endotheliopathy [ 9 , 10 ]. Important indicators for disease progression and thrombosis include elevated plasma levels of activated complement components [ 11 ] and of VWF with moderately decreased activity of ADAMTS13 (VWF-specific cleaving protease) [ 12 – 14 ].…”

Section: Introductionmentioning

confidence: 99%

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Coagulopathy and thromboembolic events a pathogenic mechanism of COVID‐19 associated with mortality: An updated review

Yousefi

Soltani

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et al. 2023

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During 2019, the SARS‐CoV‐2 emerged from China, and during months, COVID‐19 spread in many countries around the world. The expanding data about pathogenesis of this virus could elucidate the exact mechanism by which COVID‐19 caused death in humans. One of the pathogenic mechanisms of this disease is coagulation. Coagulation disorders that affect both venous and arterial systems occur in patients with COVID‐19. The possible mechanism involved in the coagulation could be excessive inflammation induced by SARS‐CoV‐2. However, it is not yet clear well how SARS‐CoV‐2 promotes coagulopathy. However, some factors, such as pulmonary endothelial cell damage and some anticoagulant system disorders, are assumed to have an important role. In this study, we assessed conducted studies about COVID‐19‐induced coagulopathy to obtain clearer vision of the wide range of manifestations and possible pathogenesis mechanisms.

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High levels of Von Willebrand factor markers in COVID-19: a systematic review and meta-analysis

Cited by 33 publications

References 59 publications

Could SARS‐CoV‐2 infection affect male fertility and sexuality?

Could SARS‐CoV‐2 infection affect male fertility and sexuality?

COVID-19 microthrombosis: unusually large VWF multimers are a platform for activation of the alternative complement pathway under cytokine storm

Coagulopathy and thromboembolic events a pathogenic mechanism of COVID‐19 associated with mortality: An updated review

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