2004
DOI: 10.1038/sj.onc.1207167
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High-mobility group A1a protein regulates Ras/ERK signaling in MCF-7 human breast cancer cells

Abstract: High-mobility group (HMG) A1 proteins are gene regulatory factors whose overexpression is frequently observed in naturally occurring human cancers. The overexpression of transgenic HMGA1 proteins in cells results in neoplastic transformation and promotes progression to malignant cellular phenotypes. To understand the underlying molecular and biological events involved in these phenomena, we used oligonucleotide microarray analyses to generate an HMGA1a-induced expression profile for approximately 22 000 genes.… Show more

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Cited by 61 publications
(67 citation statements)
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“…KL promoter activity was 4.670.8-fold more active in cells overexpressing HMGA1a (Figure 1b). This value is very close to the reported 4.270.3-fold change in KL transcription in MCF-7 cells overexpressing HMGA1a, as determined by oligonucleotide microarray analysis (Treff et al, 2004). This indicates that the effects of HMGA1a on KL expression are at the transcriptional level.…”
Section: Introductionsupporting
confidence: 73%
See 3 more Smart Citations
“…KL promoter activity was 4.670.8-fold more active in cells overexpressing HMGA1a (Figure 1b). This value is very close to the reported 4.270.3-fold change in KL transcription in MCF-7 cells overexpressing HMGA1a, as determined by oligonucleotide microarray analysis (Treff et al, 2004). This indicates that the effects of HMGA1a on KL expression are at the transcriptional level.…”
Section: Introductionsupporting
confidence: 73%
“…Also supporting this conclusion is the fact that many previous reports characterizing the role of KL in cancer biology are consistent with observations of the influence of HMGA1 on cancer cells. For example, HMGA1 overexpression in MCF-7 breast cancer cells results in increased sensitivity to EGF activation of Ras/ERK signaling (Treff et al, 2004). A similar observation (e.g.…”
Section: Introductionsupporting
confidence: 57%
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“…One way to address this issue is to search for genes of which the expression is regulated by this architectural transcription factor, such as recently described for the structurally related HMGA1 gene [17]. We have performed expression profiling experiments using embryos of the spontaneous pg/pg mouse mutant, which is HMGA2-deficient, and corresponding wild-type mouse embryos, and report on the differential impact of HMGA2 on the expression of the genes encoding the various members of the insulin-like growth factor II (IGF-II) mRNAbinding protein (IMP) family.…”
Section: Introductionmentioning
confidence: 99%