High mobility group box 1 protein (HMGB-1): A pathogenic role in preeclampsia?

Pradervand, P.-A.; Clerc, S; Frantz, Johanna; Rotaru, Corina; Bardy, Daniel; Waeber, B; Liaudet, Lucas; Vial, Yvan; Feihl, François

doi:10.1016/j.placenta.2014.06.370

Cited by 33 publications

(28 citation statements)

References 19 publications

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“…The results suggested that HMGB1 nuclear-cytoplasmic translocation may participate in the pathophysiological process of PE. Moreover, the results showed that expression of serum HMGB1 increased statistically in PE patients, which was constant with the findings of Naruse K [11,17]. This phenomenon probably indicates that HMGB1 may be a forecast molecule in PE.…”

Section: Discussionsupporting

confidence: 83%

HMGB1–RAGE signaling pathway in severe preeclampsia

Zhu

Zhang

et al. 2015

Placenta

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Section: Discussionsupporting

confidence: 83%

HMGB1–RAGE signaling pathway in severe preeclampsia

Zhu

Zhang

et al. 2015

Placenta

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“…reported no statistically significant difference in serum HMG‐1 levels between the control and pre‐eclampsia groups. By contrast, other studies found a clear increase in serum HMG‐1 levels among patients with pre‐eclampsia . The present findings were consistent with those of Pradervand et al .…”

Section: Discussionsupporting

confidence: 93%

“…By contrast, other studies found a clear increase in serum HMG‐1 levels among patients with pre‐eclampsia . The present findings were consistent with those of Pradervand et al . and Naruse et al .…”

Section: Discussionsupporting

confidence: 92%

Increased serum levels of high mobility group protein B1 and calprotectin in pre‐eclampsia

Huang

Wang

et al. 2018

Intl J Gynecology & Obste

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“…Similar to cffDNA and uric acid, maternal plasma levels of HMGB1 have been found to increase during pregnancy, and more importantly to reach exaggerated levels in women with PE (Pradervand et al 2014). This finding was corroborated in a study by Zhu et al, with further evidence revealing increased levels of HMGB1 and RAGE in the placenta of women with severe PE, especially in the cytoplasmic compartment of trophoblasts (Zhu et al 2015).…”

Section: Hmgb1mentioning

confidence: 56%

Sterile inflammation and pregnancy complications: a review

Nadeau-Vallée¹,

Obari²,

Palacios³

et al. 2016

Reproduction

219

161

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Inflammation is essential for successful embryo implantation, pregnancy maintenance and delivery. In the last decade, important advances have been made in regard to endogenous, and therefore non-infectious, initiators of inflammation, which can act through the same receptors as pathogens. These molecules are referred to as damage-associated molecular patterns (DAMPs), and their involvement in reproduction has only recently been unraveled. Even though inflammation is necessary for successful reproduction, untimely activation of inflammatory processes can have devastating effect on pregnancy outcomes. Many DAMPs, such as uric acid, high-mobility group box 1 (HMGB1), interleukin (IL)-1 and cell-free fetal DNA, have been associated with pregnancy complications, such as miscarriages, preeclampsia and preterm birth in preclinical models and in humans. However, the specific contribution of alarmins to these conditions is still under debate, as currently there is lack of information on their mechanism of action. In this review, we discuss the role of sterile inflammation in reproduction, including early implantation and pregnancy complications. Particularly, we focus on major alarmins vastly implicated in numerous sterile inflammatory processes, such as uric acid, HMGB1, IL-1α and cell-free DNA (especially that of fetal origin) while giving an overview of the potential role of other candidate alarmins.Reproduction (2016) 152 R277-R292

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High mobility group box 1 protein (HMGB-1): A pathogenic role in preeclampsia?

Cited by 33 publications

References 19 publications

HMGB1–RAGE signaling pathway in severe preeclampsia

HMGB1–RAGE signaling pathway in severe preeclampsia

Increased serum levels of high mobility group protein B1 and calprotectin in pre‐eclampsia

Sterile inflammation and pregnancy complications: a review

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