High mobility group box 1 and kidney diseases (Review)

Zhu, Ping; Xie, Li; Ding, Hua‐Sheng; Gong, Quan; Yang, Jian; Yang, Lin

doi:10.3892/ijmm.2013.1286

Cited by 24 publications

(20 citation statements)

References 58 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…HMGB1 was considered to be a novel key molecule during the IRI after KTx 6 . After it is released, HMGB1 protein can bind to its receptors that are expressed on effector cells to induce inflammation, cell proliferation, and chemotaxis, thereby acting as a bridge between the innate and adaptive immune responses 7 . HMGB1…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Allopurinol preconditioning attenuates renal ischemia/reperfusion injury by inhibiting HMGB1 expression in a rat model

et al. 2016

View full text Add to dashboard Cite

PURPOSE:To investigate the potential effects of pretreatment with allopurinol on renal ischemia/reperfusion injury (IRI) in a rat model. METHODS:Twenty four rats were subjected to right kidney uninephrectomy were randomly distributed into the following three groups (n=8): Group A (sham-operated group); Group B (ischemic group) with 30 min of renal ischemia after surgery; and Group C (allopurinol + ischemia group) pretreated with allopurinol at 50 mg/kg for 14 days. At 72 h after renal reperfusion, the kidney was harvested to assess inflammation and apoptosis. RESULTS:Pretreatment with allopurinol significantly improved renal functional and histological grade scores following I/R injury (p<0.05). Compared with Group B, the expression levels of caspase-3 and Bax were markedly reduced in Group C, meanwhile, whereas expression of bcl-2 was clearly increased (p<0.05). A newly described marker of inflammation, High Mobility Group Box 1(HMGB1), showed reduced expression in Group C (p<0.05). CONCLUSION:Pretreatment with allopurinol had a protective effect on kidney ischemia/reperfusion injury, which might be related to the inhibition of HMGB1 expression.Key words: Inflammation. Ischemia. Reperfusion. Allopurinol. Apoptosis. Rats. Allopurinol preconditioning attenuates renal ischemia/reperfusion injury by inhibiting HMGB1 expression in a rat model

show abstract

Section: Introductionmentioning

confidence: 99%

“…The signaling pathways upstream and downstream of HMGB1 remain unknown. Considering the multiple roles of HMGB1 in various pathologies, inhibition of HMGB1-mediated signaling may represent a potential effective therapeutic approach 7 . The study of…”

Section: Introductionmentioning

confidence: 99%

Allopurinol preconditioning attenuates renal ischemia/reperfusion injury by inhibiting HMGB1 expression in a rat model

et al. 2016

View full text Add to dashboard Cite

show abstract

“…High mobility group box 1 (HMGB1), a structural chromatin-binding nuclear protein existing in almost all eukaryotic cells, can be actively secreted or passively released into extracellular regions by inflammatory or necrotic cells under specific conditions [7]. Extracellular HMGB1 acts as a pluripotent cytokine in many pathophysiological processes such as infection, injury, inflammation, obesity and insulin resistance.…”

Section: Introductionmentioning

confidence: 99%

High Mobility Group Box1 Inhibitor Glycyrrhizic Acid Attenuates Kidney Injury in Streptozotocin-Induced Diabetic Rats

Zhang

Chen

et al. 2017

Kidney Blood Press Res

View full text Add to dashboard Cite

Background/Aims: High mobility group box 1 (HMGB1) is an important mediator of the inflammatory response. It has been implicated in the pathogenesis of autoimmune diseases, atherosclerosis, and obesity. However, the effects of HMGB1 on diabetic nephropathy remain unclear. Here, we investigated the potential roles and mechanisms of an HMGB1 inhibitor, glycyrrhizic acid (GA), in renal injury with the streptozotocin (STZ)-induced rat model. Methods: The diabetic rat was generated by intraperitoneal injection of STZ and then treated with the HMGB1 inhibitor GA or saline for 8 weeks. Rats were randomly divided into three groups: the normal control and saline group (Control), the diabetic rats with saline group (Diabetic) and the diabetic rats plus GA group (Diabetic+GA). Peripheral blood was obtained for measurements of blood glucose, TNF-a, IL-6 and IL-1β. The mRNA levels of proinflammatory cytokines (TNF-a, IL-6 and IL-1β), chemokines (MCP-1), intercellular adhesion molecules (ICAM-1) and TGF-β1 in the kidneys were evaluated by quantitative real-time PCR. The protein levels of phosphorylated(p) and total(t) p38 MAPK, JNK, ERK, and NF-κB were measured by western blot. Results: We found that diabetic rats showed obvious renal lesions, an elevated urinary albumin/creatinine ratio (UACR) and increased expression levels of TGF-β1 and Col-IV in the kidneys, accompanied by significantly enhanced expression levels of HMGB1, receptor for advanced glycation end products (RAGE) and toll-like receptor 4 (TLR-4) in the kidney tissue. Furthermore, the GA treatment significantly reduced the UAC levels, ameliorated renal injury, and decreased the TNF-α, 1L-6, IL-1β, MCP-1, ICAM-1, TGF-β1 and Col-IV levels. Importantly, the expression levels of HMGBI, RAGE and TLR4 in the kidney tissues of the diabetic rats were also inhibited by the GA treatment. Furthermore, the GA treatment significantly reduced the phosphorylation levels of ERK and p38 MAPK and suppressed NF-κB translocation from the cytoplasm to the nucleus. Conclusion: Our findings indicate that the HMGB1 inhibitor GA may improve renal injury and inflammatory responses in diabetic rats by regulating RAGE/TLR4-related ERK and p38 MAPK/NF-κB activation.

show abstract

“…HMGB1 has been demonstrated to act as a pro-inflammatory mediator and participate in human immune systems diseases (14,15). Studies indicated that innate immune cells, including macrophages and monocytes, actively secreted HMGB1 (13,16). It has been demonstrated that HMGB1 not only induces various cytokines, such as interleukin (IL)-1, IL-6 and IL-8, but also stimulates necrosis-induced inflammation.…”

Section: Introductionmentioning

confidence: 99%

“…The high mobility group box 1 protein (HMGB1), which belongs to the most evolutionarily conserved proteins in the nucleus and cytoplasm, is one of the members of high mobility group nuclear protein family (13). HMGB1 has been demonstrated to act as a pro-inflammatory mediator and participate in human immune systems diseases (14,15).…”

Section: Introductionmentioning

confidence: 99%