High mobility group box 1 (HMGB1) in COVID-19

Kafi, Fatemeh; Bolourian, Alireza; Mojtahedi, Zahra; Pouramini, Alireza

doi:10.34172/jpe.2021.11

Cited by 7 publications

(6 citation statements)

References 9 publications

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“…Children with multisystem inflammatory syndrome usually experience symptoms similar to those of a "cytokine storm," [38], which is an inflammatory reaction in patients with Covid-19 and can be fatal. These symptoms may include persistent fever and gastrointestinal, respiratory, neurological, and cardiovascular problems, including shock and inflammation of the heart muscle [39,40], Studies by Arditi et al (2018) show biological processes involved in pediatric multisystem inflammatory syndrome, cytokine storm, and toxic shock syndrome. Toxic shock syndrome is a rare complication of life-threatening bacterial infections.…”

Section: Results and Dissectionmentioning

confidence: 99%

“…In this regard, recent studies have revealed that the platelet-to-lymphocyte (PLR) ratio is a new inflammatory indicator and predictor of cardiovascular diseases complications [38]. In addition, high pre-procedural PLR in acute coronary syndrome group has been reported as an independent factor with high predictive power for long-term mortality [39][40][41]. However, the combined benefit of PLR and NLR in predicting long-term side effects in coronary artery disease (CAD) has not been adequately assessed (Figure 2).…”

Section: Introductionmentioning

confidence: 99%

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Jouzdani

Mohebbi

2021

J. Med. Chem. Sci.

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Section: Results and Dissectionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Jouzdani

Mohebbi

2021

J. Med. Chem. Sci.

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“…Furthermore, high mobility group box 1(HMGB1) is regarded as a DAMP signal for TLR4 to trigger the release of pro‐inflammatory cytokines mainly IL‐6 and tumor necrosis factor (TNF‐α) 77 . HMGB1 is activated during SARS‐CoV‐2 infection leading to hyperinflammation and the development of cytokine storm 78 .…”

Section: Sr‐bi and Inflammatory Signaling Pathways In Covid‐19mentioning

confidence: 99%

The potential role of scavenger receptor B type I (SR‐BI) in SARS‐CoV‐2 infection

Alkazmi

Al-Kuraishy

Al-Gareeb

et al. 2023

Immunity Inflam & Disease

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Scavenger receptor type B I (SR-BI), the major receptor for high-density lipoprotein (HDL) mediates the delivery of cholesterol ester and cholesterol from HDL to the cell membrane. SR-BI is implicated as a receptor for entry of severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2). SR-BI is colocalized with the angiotensin-converting enzyme 2 (ACE2) increasing the binding and affinity of SARS-CoV-2 to ACE2 with subsequent viral internalization. SR-BI regulates lymphocyte proliferation and the release of pro-inflammatory cytokines from activated macrophages and lymphocytes. SR-BI is reduced during COVID-19 due to consumption by SARS-CoV-2 infection. COVID-19-associated inflammatory changes and high angiotensin II (AngII) might be possible causes of repression of SR-BI in SARS-CoV-2 infection. In conclusion, the downregulation of SR-BI in COVID-19 could be due to direct invasion by SARS-CoV-2 or through upregulation of proinflammatory cytokines, inflammatory signaling pathways, and high circulating AngII. Reduction of SR-BI in COVID-19 look like ACE2 may provoke COVID-19 severity through exaggeration of the immune response. Further studies are invoked to clarify the potential role of SR-BI in the pathogenesis of COVID-19 that could be protective rather than detrimental.

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“…According to a study by Southern University of Science and Technology in China [12], people with blood type A have a significantly higher risk of getting the corona virus than non-A blood types. In addition, according to researchers, people with blood type O compared People with non-O blood types have a significantly reduced risk of developing the disease [13][14][15]. This study was designed to investigate the relationship between ABO blood groups and their response to coronary artery syndrome.…”

Section: Introductionmentioning

confidence: 99%

Untitled

2021

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The aim of this study was to investigate the relationship between ABO blood groups and the rate and severity of morbidity and mortality in patients with Covid-19 in Zahedan. The present study is a descriptive-analytical study and includes a sample of 349 patients with Covid-19 referred to hospitals in Zahedan from March 2016 to August 2017. The sampling method was census and for data collection, case studies and checklists were used. The data were analyzed by Chi-square test through SPSS software. Among the 328 patients, 132(41%) had blood type O, 92(28%) had blood type A, 80(24%) had blood group B and 24(7%) had AB blood type. There was no significant relationship between blood groups and age (P <0.150). Patients in the age group of 30-60 years with 208 (63.4%) had the highest number, of whom 78 (23.8%) had blood type O. There was a significant relationship between blood groups and gender (P = 0.001), so male patients with 178 (54.3%) were more, of whom 72 (22%) had blood type O. There was no significant relationship between blood groups and place of hospitalization (P <0.121); however, inpatient department patients with 150 (45.7%) had the highest number, of whom 62 (41.3%) had blood type O. There was no significant relationship between blood groups and severity of covid-19 (P <0.121); however, patients with moderate severity had the highest number with 150 (45.7%) patients, of whom 62 (41.3%) had blood type O.

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High mobility group box 1 (HMGB1) in COVID-19

Cited by 7 publications

References 9 publications

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The potential role of scavenger receptor B type I (SR‐BI) in SARS‐CoV‐2 infection

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