High molecular weight adiponectin dominates in cord blood of newborns but is unaffected by pre‐eclamptic pregnancies

Odden, Nancy; Mørkrid, Lars

doi:10.1111/j.1365-2265.2007.02981.x

Cited by 22 publications

(20 citation statements)

References 32 publications

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“…28 Recently, adiponectin in cord blood has been described as predominantly in the HMW form. 29 Thus, the predominance of human milk adiponectin in the HMW form is consistent with both resistance to digestion and biological activity in the infant.…”

Section: Discussionmentioning

confidence: 83%

Human Milk Adiponectin Is Associated with Infant Growth in Two Independent Cohorts

Woo

Guerrero²,

Altaye

et al. 2009

Breastfeeding Medicine

110

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Background: Adiponectin, a circulating adipocyte protein, is associated with lower obesity. We have previously shown that adiponectin is present in human milk. This study determined whether higher milk adiponectin is associated with infant growth and investigated milk adiponectin's oligomeric form. Design and Methods: This is a study of two parallel longitudinal cohorts of breastfed infants born between 1998 and 2005. Forty-five mother-infant pairs from Cincinnati, OH and 277 mother-infant pairs from Mexico City, Mexico were analyzed. All participants were healthy, term infants breastfed at least 1 month who completed 6 months of follow-up. Monthly milk samples (n ϭ 1,379) up to 6 months were assayed for adiponectin by radioimmunoassay. Infant weight-for-age, length-for-age, and weight-for-length Z-scores up to 6 months of age were calculated using World Health Organization standards. Repeated-measures analysis was conducted. The structural form of human milk adiponectin was assessed by western blot. Results: In the population studies, initial milk adiponectin was 24.0 Ϯ 8.6 g/L and did not differ by cohort. Over the first 6 months, higher milk adiponectin was associated with lower infant weight-for-age Z-score (Ϫ0.20 Ϯ 0.04, p Ͻ 0.0001) and weight-for-length Z-score (Ϫ0.29 Ϯ 0.08, p ϭ 0.0002) but not length-for-age Z-score, adjusted for covariates, with no difference by cohort. By western blot, human milk adiponectin was predominantly in the biologically active high-molecular-weight form. Conclusions: Our data suggest milk adiponectin may play a role in the early growth and development of breastfed infants.

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Section: Discussionmentioning

confidence: 83%

Human Milk Adiponectin Is Associated with Infant Growth in Two Independent Cohorts

Woo

Guerrero²,

Altaye

et al. 2009

Breastfeeding Medicine

110

View full text Add to dashboard Cite

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“…That study included only 22 pregnancies with preeclampsia, and differences in adiponectin levels could not be reliably studied. In another Norwegian study, there was no difference in cord blood levels of adiponectin in the offspring of preeclamptic pregnancies and pregnancies without preeclampsia, after adjustment for length of gestation [26] . That study was hospital-based, and the comparison groups were rather small (30 preeclampsia and 62 control pregnancies).…”

Section: Discussionmentioning

confidence: 99%

“…In a recent study the most biological active isoform of adiponectin was found to represent the greatest part of total adiponectin in cord blood [26] . However, we do not know if this is the case in offspring of mothers with preeclampsia or in prematurely born offspring, and it would be of interest to study different isoforms of adiponectin in cord blood.…”

Section: Discussionmentioning

confidence: 99%

Preeclampsia and Adiponectin in Cord Blood

Ogland

Romundstad

Vefring³

et al. 2010

Horm Res Paediatr

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Aims: To compare cord blood concentrations of total adiponectin in the offspring of pregnancies with and without preeclampsia. Methods: Using a Luminex analyzer, cord blood adiponectin was measured in 182 singleton pregnancies with preeclampsia and compared to adiponectin measured in 511 singleton pregnancies without preeclampsia. Results: Adiponectin levels in cord blood increased with increasing gestational age, but overall, crude levels were similar in pregnancies with and without preeclampsia. However, in pregnancies with early delivery (weeks 32–36), and in pregnancies with delivery after spontaneous contractions, adiponectin levels were higher in the preeclampsia group. Conclusion: In preterm pregnancies and in pregnancies with spontaneous contractions, adiponectin levels in cord blood were higher in the preeclampsia group than in pregnancies without preeclampsia, maybe reflecting the need to optimize energy in preeclampsia.

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“…[47], показав, что у па-циенток с гестационной гипертензией и ПЭ, разви-вающейся в поздние сроки беременности, в первом триместре регистрируются значительно более низкие концентрации адипонектина по сравнению со здо-ровыми беременными из группы контроля. В дру-гих исследованиях не выявлено значимых различий в концентрациях адипонектина в ранние и поздние сроки гестации при развитии ПЭ и физиологической беременности [48]. Этиология таких противоречивых результатов остается до конца не выясненной.…”

Section: влияние адипонектина на инсулинорезистентность и развитие сиunclassified

Metabolic disorders in adipocytokine imbalance and gestational complications

Чабанова

Борисовна²,

Mataev³

et al. 2017

Obes. metabol.

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Adipose tissue as an endocrine organ synthesizes a large number of biologically active substances, adipocytokines, which have both local and systemic effects influencing the vascular wall, tissue sensitivity to insulin, glucose metabolism, and systemic inflammation. The data obtained from clinical and experimental studies demonstrate the close relationship between the imbalance of adipocytokines and pregnancy complications such as insulin resistance, gestational diabetes, and preeclampsia. In this connection, close attention of obstetrician-gynecologists and endocrinologists is focused on etiopathogenic aspects of the formation of gestational complications with metabolic disorders caused by an imbalance of adipocytokines with maternal obesity and to the search for markers of these disorders. The review presents the current literature data on adipose tissue hormones and their influence on the course of a gestational process.

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High molecular weight adiponectin dominates in cord blood of newborns but is unaffected by pre‐eclamptic pregnancies

Abstract: Adiponectin in cord blood from PE pregnancies may not be a tentative risk marker for Metabolic Syndrome-linked diseases. HMW adiponectin is the dominant form of adiponectin in cord blood. Its role during pregnancy and postnatal life should be further explored.

Cited by 22 publications

References 32 publications

Human Milk Adiponectin Is Associated with Infant Growth in Two Independent Cohorts

Human Milk Adiponectin Is Associated with Infant Growth in Two Independent Cohorts

Preeclampsia and Adiponectin in Cord Blood

Metabolic disorders in adipocytokine imbalance and gestational complications

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