High-molecular-weight adiponectin is a predictor of progression to metabolic syndrome: a population-based 6-year follow-up study in Japanese men

Seino, Y.; Hara, Hiroshi; Saito, Ikuo; Itoh, Hiroshi

doi:10.1016/j.metabol.2008.10.008

Cited by 65 publications

(45 citation statements)

References 33 publications

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“…Plasma levels of adiponectin and HMW adiponectin in our study are in the range of those reported by other investigators for healthy females (28)(29)(30). In accordance with previous studies we observed a positive association between adiponectin and the cardioprotective lipid HDL and a negative association between the inflammatory cytokine CRP and adiponectin at baseline (5,22,(31)(32)(33)(34).…”

Section: Discussionsupporting

confidence: 92%

Implanon use lowers plasma concentrations of high-molecular-weight adiponectin

Merki‐Feld

Imthurn

Rosselli

et al. 2011

Fertility and Sterility

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Section: Discussionsupporting

confidence: 92%

Implanon use lowers plasma concentrations of high-molecular-weight adiponectin

Merki‐Feld

Imthurn

Rosselli

et al. 2011

Fertility and Sterility

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“…However, there was no association between total, low molecular weight or HMW adiponectin levels and blood pressure. Similarly, Seino et al [249] reported that a decrease in HMW adiponectin is a good predictor of progression to metabolic syndrome in a 6-year follow-up study of Japanese men. Those results strengthen the hypothesis that adiponectin levels could be considered an important biomarker of metabolic syndrome.…”

Section: Metabolic Syndromementioning

confidence: 87%

Adiponectin action from head to toe

Brochu-Gaudreau

Rehfeldt

Blouin

et al. 2009

Endocr

281

247

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Adiponectin, the most abundant protein secreted by white adipose tissue, is known for its involvement in obesity-related disorders such as insulin resistance, type 2 diabetes mellitus and atherosclerosis. Moreover, modulation of the circulating adiponectin concentration is observed in pathologies that are more or less obesity-related, such as cancer and rheumatoid arthritis. The wide distribution of adiponectin receptors in various organs and tissues suggests that adiponectin has pleiotropic effects on numerous physiological processes. Besides its well-known insulin-sensitizing, anti-inflammatory and antiatherosclerotic properties, accumulating evidence suggests that adiponectin may also have anticancer properties and be cardioprotective. A beneficial effect of adiponectin on female reproductive function was also suggested. Since adiponectin has numerous beneficial biological functions, its use as a therapeutic agent has been suggested. However, the use of adiponectin or its receptors as therapeutic targets is complicated by the presence of different adiponectin oligomeric isoforms and production sites, by multiple receptors with differing affinities for adiponectin isoforms, and by cell-type-specific effects in different tissues. In this review, we discuss the known and potential roles of adiponectin in various tissues and pathologies. The therapeutic promise of administration of adiponectin and the use of its circulating levels as a diagnostic biomarker are further discussed based on the latest experimental studies.

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“…Even after adjusting for age, study enrollment time, smoking, and other factors, the incidence of myocardial infarction in the lowest quartile of the adiponectin concentration was 2.5 times higher than that in the top quartile of the concentration ( p 0.001) 35) . We also investigated whether a decreased HMW adiponectin concentration is a predictor of progression to metabolic syndrome during a 6-year follow-up period in Japanese men 36) . This study included 416 men without metabolic syndrome, aged 30-59 years at baseline, who had participated in annual health checkups in both 2000 and 2006.…”

Section: Longitudinal Studies Related To the Serum Adiponectin Levelmentioning

confidence: 99%

Serum high-molecular-weight adiponectin as a marker for the evaluation and care of subjects with metabolic syndrome and related disorders

Hara

Yamamoto

Seino-Yoshihara

et al. 2010

JAT

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In 1996, adiponectin was reported to be the most abundant transcript in adipose tissue. Animal studies revealed that administering adiponectin improves insulin resistance and blood glucose levels and inhibits atherosclerosis. In the present article, we review the significance of measuring serum high-molecular-weight (HMW) adiponectin levels in human subjects.Our cross-sectional studies revealed that the serum HMW adiponectin concentration was 1.9 times higher in healthy Japanese females than males and had a strong positive correlation with HDLcholesterol but a negative correlation with BMI and the homeostasis model assessment insulin resistance index (HOMA-IR). They also indicated that the serum HMW adiponectin concentration had a stronger association with HOMA-IR and metabolic syndrome than the total adiponectin concentration.Our longitudinal study, a 6-year follow-up of Japanese men, suggested that a decreased level of HMW adiponectin is a predictor of progression to metabolic syndrome. In another intervention study, lifestyle modification for 3 months induced a decrease in BMI and waist circumference and an increase in serum HMW adiponectin but not the total adiponectin level in 16 Japanese males with metabolic syndrome.Administering thiazolidinediones to diabetic patients increased the serum HMW adiponectin concentration 3 fold and improved glucose and lipid profiles and blood pressure. Some people may inherit a lower serum concentration of adiponectin, and have a higher risk of developing cardiovascular diseases.It is suggested that HMW adiponectin is a useful marker for the evaluation and care of subjects with metabolic syndrome and related disorders.

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High-molecular-weight adiponectin is a predictor of progression to metabolic syndrome: a population-based 6-year follow-up study in Japanese men

Cited by 65 publications

References 33 publications

Implanon use lowers plasma concentrations of high-molecular-weight adiponectin

Implanon use lowers plasma concentrations of high-molecular-weight adiponectin

Adiponectin action from head to toe

Serum high-molecular-weight adiponectin as a marker for the evaluation and care of subjects with metabolic syndrome and related disorders

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