High mortality in diabetic patients with acute myocardial infarction: Cardiovascular co-morbidities contribute most to the high risk

Kvan, Elena; Pettersen, Kjell I.; Sandvik, Leiv; Reikvam, Aasmund

doi:10.1016/j.ijcard.2006.11.003

Cited by 29 publications

(27 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Na Noruega, em estudo com pacientes internados por episódio de infarto agudo do miocárdio, foi observado que os indivíduos diabéticos apresentavam maior frequência de comorbidades como infarto pré-vio, angina e insuficiência cardíaca em relação aos que não apresentavam essa condição e tinham menor sobrevida (28). Comparando a mortalidade em indivíduos que apresentaram eventos coronarianos agudos, participantes de dois estudos de coorte no Reino Unido, foi verificado que, apesar dos avanços no tratamento, os ganhos de sobrevida de curto prazo observados para todo o grupo, a longo prazo, não se mantinham para os indivíduos diabéticos (23).…”

Section: Discussionunclassified

Tendência da mortalidade por diabetes melito em capitais brasileiras, 1980-2007

Mattos

Luz

Santiago

et al. 2012

Arq Bras Endocrinol Metab

View full text Add to dashboard Cite

RESUMOObjetivo: Analisar o padrão de mortalidade por diabetes nas capitais brasileiras entre 1980 e 2007. Materiais e métodos: Foram calculadas taxas de mortalidade quadrienais e anuais, padronizadas por idade pela população mundial. Modelos de regressão linear foram estimados para análise da tendência nas capitais. Resultados: No primeiro quadriênio, a taxa mais elevada correspondeu a 42,89/100.000 em Aracaju e, no último, a 54,38/100.000 em São Luís. Foram observadas tendências estatisticamente significativas de incremento na maioria das capitais, embora com diferenças regionais. Belo Horizonte foi a única capital a mostrar tendência de declínio. Conclusões: Uma parte do incremento observado poderia ser atribuída a melhoras no acesso ao diagnóstico e na certificação da causa de morte, porém diferenças regionais na prevalência de fatores de risco e proteção para a doença possivelmente também estão implicadas. A não disponibilidade de série histórica de casos incidentes impossibilita determinar se esses resultados refletem tendências atuais da incidência do diabetes no Brasil. Arq Bras Endocrinol In the first quadrennial period, the highest rate was 42.89/100,000 in Aracaju; and in the last quadrennial period, 54.38/100,000 in São Luis. Although mortality rates showed statistically significant incremental trends in most capitals, there were regional differences. Belo Horizonte was the only capital to show a declining trend. Conclusions: Part of the observed increment could be attributed to improvements in access to diagnosis and death certification, but regional differences in the prevalence of diabetes risk and protective factors might also be implicated. The absence of a time series of incident cases makes it difficult to determine if these results reflect current trends in the incidence of diabetes in Brazil. InTRODUçãO O padrão epidemiológico do diabetes melito tipo 2 no mundo tem se modificado nas últimas déca-das e essas mudanças têm sido atribuídas a modificações nos hábitos alimentares, aumento da inatividade física e da obesidade, à urbanização e ao envelhecimento da população (1). Espera-se que, entre 2000 e 2030, sua prevalência global dobre, atingindo cerca de 366 mi-

show abstract

Section: Discussionunclassified

Tendência da mortalidade por diabetes melito em capitais brasileiras, 1980-2007

Mattos

Luz

Santiago

et al. 2012

Arq Bras Endocrinol Metab

View full text Add to dashboard Cite

show abstract

“…2,3 Considerable evidence has demonstrated that diabetic patients are more vulnerable to myocardial ischemia/reperfusion (I/R) injury than nondiabetic patients in the clinical settings of coronary angioplasty and cardiac bypass surgery. [4][5][6] These clinical data suggest that vigorous therapeutic strategies for protecting the heart against I/R injury are required to improve the prognosis in diabetic patients with ischemic heart disease.…”

Section: Introductionmentioning

confidence: 99%

Cardioprotective Effects of Luteolin on Ischemia/Reperfusion Injury in Diabetic Rats Are Modulated by eNOS and the Mitochondrial Permeability Transition Pathway

Yang

Qian

Zhang

et al. 2015

Journal of Cardiovascular Pharmacology

View full text Add to dashboard Cite

Myocardial ischemia/reperfusion (I/R) injury in diabetes is associated with oxidative stress, endothelial nitric oxide synthase (eNOS) dysfunction, and mitochondrial collapse, whereas luteolin is known to protect the cardiovascular system against diabetes and I/R injury. Here, we investigated whether luteolin pretreatment diminishes myocardial I/R injury in diabetic rats by affecting eNOS and the mitochondrial permeability transition pore (mPTP). After diabetic rats were produced by streptozotocin treatment (65 mg/kg) for 3 weeks, luteolin (100 mg·kg·d) or L-NAME (25 mg·kg·d) was administered intragastrically for 2 weeks. Hearts were then isolated and subjected to 30 minutes of global ischemia followed by 120 minutes of reperfusion. Pretreatment with luteolin significantly improved left ventricular function and coronary flow throughout reperfusion, increased cardiac tissue viability and manganese superoxide dismutase (MnSOD) activity, and reduced coronary lactate dehydrogenase release, and the myocardial malonaldehyde level in diabetic I/R rat hearts. All these improving effects of luteolin were significantly attenuated by L-NAME. Luteolin also significantly upregulated eNOS expression in diabetic rat hearts after I/R. Ca-induced mPTP opening and mitochondrial inner membrane potential reduction were significantly inhibited in ventricular myocytes isolated from luteolin-treated diabetic rats, and this effect was attenuated by L-NAME. These findings indicate that luteolin protects the diabetic heart against I/R injury by upregulating the myocardial eNOS pathway, and downstream effects include the enhancement of MnSOD and inhibition of mPTP.

show abstract

“…In fact, cardiovascular disease is the most life threatening of the diabetic complications and diabetics are two-to four-fold more likely to die of cardiovascular-related causes than nondiabetics. [11] Screening Screening ECGs (either at rest or with exercise) are not recommended in those without symptoms who are at low risk. In those at higher risk the evidence for screening with ECGs is inconclusive.…”

Section: Risk Factorsmentioning

confidence: 99%

Diagnosis of Cardiovascular Diseases by Boosted Neural Networks

Can

2013

scjournal

View full text Add to dashboard Cite

A boosting by filtering technique for neural network systems with back propagation together with a majority voting scheme is presented in this paper. Previous research with regards to predict the presence of cardiovascular diseases has shown accuracy rates up to 72.9%. Using a boosting by filtering technique prediction accuracy increased over 80%. The designed neural network system in this article presents a significant increase of robustness and it is shown that by majority voting of the parallel networks, recognition rates reach to > 90 in the V.A. Medical Center, Long Beach and Cleveland Clinic Foundation data set.

show abstract

High mortality in diabetic patients with acute myocardial infarction: Cardiovascular co-morbidities contribute most to the high risk

Cited by 29 publications

References 30 publications

Tendência da mortalidade por diabetes melito em capitais brasileiras, 1980-2007

Tendência da mortalidade por diabetes melito em capitais brasileiras, 1980-2007

Cardioprotective Effects of Luteolin on Ischemia/Reperfusion Injury in Diabetic Rats Are Modulated by eNOS and the Mitochondrial Permeability Transition Pathway

Diagnosis of Cardiovascular Diseases by Boosted Neural Networks

Contact Info

Product

Resources

About