High Mycoplasma pneumoniae Loads and Persistent Long-term Mycoplasma pneumoniae DNA in Lower Airway Associated with Severity of Pediatric Mycoplasma pneumoniae Pneumonia

Abstract

Background: An increased number of refractory mycoplasma pneumoniae (MP) pneumonia (MPP) cases have been reported. However the duration of MP infection in lower airway and the course of anti-MP treatment remains unclear. Methods: We retrospectively reviewed the medical records of 94 MPP children. Patients were classified into two groups. The long-term group (Group LT) was defined as bronchoalveolar lavage fluid (BALF) remained MP-positive by PCR after 30 days of the disease course. The non-long-term group (Group NLT) was defined as BALF became MP-negative by PCR within 30 days of disease and patients who only needed one bronchoscopy lavage therapy. MP loads, clinical outcomes were analyzed along with other clinical measurements. Results: The average levels of inflammatory markers such as C reactive protein and lactate dehydrogenase in Group LT were significantly higher than those in Group NLT. Airway and lung damage in Group LT were more severe than Group NLT. 28 patients developed necrotizing pneumonia and 8 patients developed pulmonary embolism in Group LT. Mean maximum MP loads in BALF were 10 7.46±0.93 and 10 4.86±0.93 in Groups LT and NLT, respectively. There was persistent MP DNA in Group LT, even lasted for 120 days. One severe MPP patient in Group LT had MP-associated bloodstream infection. After 3 months of follow-up, chest imaging revealed incomplete absorption of pulmonary consolidation in 33 patients of Group LT [including 13 airway obliterans (AO) patients] and in 7 patients of Group NLT (including 2 AO patients). Conclusion: MP loads of BALF were associated with the subsequent duration of MP DNA in lower airway. High MP loads and persistent long-term MP DNA in lower airway were associated with severity of pediatric MPP.

An analysis of 20 clinical cases of refractory mycoplasma pneumonia in children

“…As such, how to diagnose and treat RMPP correctly has become a difficult problem for pediatricians (10)(11)(12)(13)(14)(15). The main clinical features of RMPP were persistent high fever, coughing, a marked increase in inflammatory indicators (including CRP, LDH, SF), large consolidation on imaging, necrosis in some cases, and mucus embolism and/or mucosal necrosis under a bronchoscopy (16,17).…”

Thrombosis associated with mycoplasma pneumoniae infection (Review)

“…Cerebral infarction developed 2 days to 3 weeks after Mycoplasma pneumoniae infection (29)(30)(31)(33)(34)(35)(36)(37)(38)(39)(40)(41)43,44). Chest imaging of certain patients revealed pulmonary embolism 11-29 days after Mycoplasma pneumonia infection (52). A previous case report identified a cardiac thrombus 4 days after Mycoplasma pneumoniae infection (46).…”