High neutrophil-to-lymphocyte ratio is a significant predictor of depressive symptoms in maintenance hemodialysis patients: a cross-sectional study

Feng, Jingchun; Lu, Xiangxue; Li, Han; Wang, Shixiang

doi:10.1186/s12888-022-03963-7

Cited by 7 publications

(6 citation statements)

References 36 publications

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“…Previous study has investigated the correlation between depression status and in ammation index in MHD patients, indicating that high NLR is an independent risk factor for depression scores in MHD patients and can be used to predict depression status in MHD patients [40]. This study reports for the rst time the correlation between SII and depressive status in MHD patients, and the results show that high SII is an independent risk factor for depressive status in MHD patients.…”

Section: Discussionmentioning

confidence: 61%

Systemic immune inflammation index is a valuable marker for predicting hemodialysis patients with depression: a cross-sectional study

han,

张,

Kong

et al. 2024

Preprint

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Background：Maintenance hemodialysis(MHD) patients suffer from enormous physical, mental stress and poor quality of life, so an increasing number of patients are in a long-term state of depression. A prominent feature of MHD patients is chronic persistent inflammation, which is also an important mechanism for the onset of depression. Therefore, finding economically convenient inflammatory markers to predict and diagnose the onset of depression in MHD patients is of great value. As a novel inflammatory marker, systemic immune inflammation index(SII) can more comprehensively reflect the inflammation and immunity level of patients. This study aims to explore the relationship between SII and depressive symptoms in MHD patients. Methods：A cross-sectional study was conducted on 208 MHD patients from three dialysis centers. Based on the Hospital Anxiety and Depression Scale(HADS) scores, patients were divided into non-depression and depression groups. Inter group comparison and multivariate logistic regression analysis were performed to determine whether SII is an independent risk factor for depression in MHD patients. Receiver operating characteristic(ROC) curve was used to evaluate the predictive value of SII on depression symptoms in MHD patients. Results：38.83% of the included patients were in a state of depression. After adjusting for all confounding factors, MHD patients with SII>963.93 had a 4.709 times higher risk of depression than those with SII≤478.32 (OR=4.709, 95% CI 1.821-12.178, P<0.01). ROC analysis showed that SII>685.11 was the best cutoff value for MHD depression patients, and the area under the curve (AUC) was 0.681. Conclusions：High SII is an independent risk factor for depressed MHD patients and an ideal inflammatory marker for predicting and identifying depression in MHD patients.

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Section: Discussionmentioning

confidence: 61%

Systemic immune inflammation index is a valuable marker for predicting hemodialysis patients with depression: a cross-sectional study

han,

张,

Kong

et al. 2024

Preprint

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“…[12] Research by Feng shows that the red cell distribution width (RDW) is related to depressive symptoms, where the group with mild depressive symptoms is found to be higher than the group without depressive symptoms. [13] However, another study that compared individuals with depressive symptoms with those without any mental illness reported that there was no significant difference in the RDW values of the two groups. This could be due to differences in the number of study samples, thereby reducing statistics significance.…”

Section: Discussionmentioning

confidence: 98%

Correlation Between Depression Level and Red Blood Cell Distribution Width (RDW) and Erythrocyte Sedimentation Rate (ESR) in Chronic Kidney Disease (CKD) Patients Undergoing Regular Hemodialysis at Haji Adam Malik General Hospital Medan

Prianto,

Lubis,

Nasution

2023

JSocMed

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Introduction: Chronic Kidney Disease are related to inflammation and stress levels therefore depression is a predictor that will increase the morbidity and mortality of patients with chronic kidney disease undergoing hemodialysis. Method: This research is an analytical study with a cross-sectional design which carried out in Januari until February 2023, at Hemodialysis Installation of RSUP. H. Adam Malik. To analyze the correlation between the Depression Level and Red Blood Cell Distribution Width (RDW) and Erythrocyte Sedimentation Rate (ESR), the Pearson correlation test was used if the data was normally distributed. If the data is not normally distributed, Spearman's correlation test is performed. Statistical analysis using 95% confidence level (p<0.05). Results: In this research, demographic characteristics of 85 patients with mean age of the patients was 49.56 years old with a standard deviation of 13.46. Based on Spearman rho test it was found that there was a significant correlation between RDW and the BDI II score with p value 0.003. The degree of correlation or r value was 0.318. This indicates that there is a weak correlation between the RDW score and the BD II score. Based on Pearson test it was found that there was a significant correlation between ESR and the BDI II score with p value 0.009. The degree of correlation or r value was 0.280. This indicates that there is a weak correlation between the ESR value and the BD II score. Conclusion: Level of depression were found to be correlated with Red Blood Cell Distribution Width (RDW) and Erythrocyte Sedimentation Rate (ESR) in CKD patients whose undergoing regular hemodialysis.

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“…Wang et al [ 46 ] found an association between NLR and clinically relevant depressive symptoms in people with diabetes. In a cross-sectional study, Feng et al [ 47 ] found high NLR is a significant predictor of depressive symptoms in patients. There are also works contradicting the relationship between NLR and depression.…”

Section: Discussionmentioning

confidence: 99%

“…This finding is consistent with previous studies that have shown an association between inflammation and depression in the general population. [ 46 , 47 ] ROC analysis determined that an NLR cutoff of 3.26 had 88.2% specificity and 48.6% sensitivity in distinguishing between depression groups. Patients with an NLR higher than 3.26 were approximately 6.1 times more likely to belong to the moderate or major depression group than those with a lower NLR.…”

Section: Discussionmentioning

confidence: 99%

The relationship between neutrophil lymphocyte ratio, platelet lymphocyte ratio, and depression in dialysis patients

Tutan,

Erdoğan Kaya,

Eser

2023

Medicine

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Chronic kidney disease is a worldwide public health issue with rising incidence, morbidity/mortality, and cost. Depression and chronic renal disease often coexist, and psychological illnesses are associated with poor results. Early identification of depression reduces morbidity and death. Neutrophil to lymphocyte ratio (NLR) and platelet to lymphocyte ratio (PLR) are reported as practical biomarkers of inflammation and immune system activation. In this study, we aimed to determine the association of NLR and PLR with depression in dialysis patients. This study included 71 adults over 18 without known hematologic or oncologic disease, drug use, or chronic inflammatory diseases. Comorbid chronic diseases, laboratory data, and Beck depression inventory scores were prospectively recorded. A comparison of 2 groups according to the existence of depression was made, and a binomial logistic regression test was used to determine the association between the variables and the presence of depression after adjusting for confounding factors. A receiver operating curve analysis was used to differentiate groups with and without severe depression. Seventy-one patients met the study criteria, with 46 hemodialysis and 25 peritoneal dialysis patients. The majority had hypertension and diabetes mellitus, with 47.89% having minimal-minor depression and 52.11% having moderate-major depression. The 2 groups were similar regarding chronic diseases, with no significant differences in serum creatinine levels, glucose, lipid profiles, or electrolytes. However, when the NLR of the 2 groups was compared, the median was higher in patients with moderate or major depression. Multivariate analysis showed no significant differences between the groups in PLR, triglyceride to glucose ratio, and C-reactive peptide to albumin ratio. The best NLR cutoff value was 3.26, with 48.6% sensitivity, 88.2% specificity, 81.8% positive predictive value, 61.2% negative predictive value, and 67.6% test accuracy. Depression is one of the most common psychiatric conditions in dialysis patients and is linked to increased morbidity, mortality, treatment failure, expense, and hospitalization. NLR helped predict moderate-to-major depression in dialysis patients, even after controlling for confounding factors in multivariate analysis. This study indicated that an NLR successfully identified depressive groups, and patients with an NLR value >3.26 were 6.1 times more likely to have moderate or major depression.

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High neutrophil-to-lymphocyte ratio is a significant predictor of depressive symptoms in maintenance hemodialysis patients: a cross-sectional study

Cited by 7 publications

References 36 publications

Systemic immune inflammation index is a valuable marker for predicting hemodialysis patients with depression: a cross-sectional study

Systemic immune inflammation index is a valuable marker for predicting hemodialysis patients with depression: a cross-sectional study

Correlation Between Depression Level and Red Blood Cell Distribution Width (RDW) and Erythrocyte Sedimentation Rate (ESR) in Chronic Kidney Disease (CKD) Patients Undergoing Regular Hemodialysis at Haji Adam Malik General Hospital Medan

The relationship between neutrophil lymphocyte ratio, platelet lymphocyte ratio, and depression in dialysis patients

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