High neutrophil-to-lymphocyte ratio predicts short survival in multiple system atrophy

Zhang, Lingyu; Cao, Bei; Hou, Yanbing; Wei, Qianqian; Ou, Ruwei; Zhao, Bi; Shang, Huifang

doi:10.1038/s41531-021-00267-7

Cited by 23 publications

(26 citation statements)

References 25 publications

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“…In line with these results, we found high laboratory markers of WBC, ANC, ESR, and CRP, which reflect inflammation predicted higher mortality in the MSA population. A recent report showed that the neutrophil to lymphocyte (NRL) ratio significantly predicted higher mortality in MSA 11 , which corresponds with our data showing high (>mean) NRL predicted higher mortality (HR = 1.80[1.34, 2.42]).…”

supporting

confidence: 92%

Laboratory prognostic factors for the long-term survival of multiple system atrophy

Shin

Kim

Lee

et al. 2022

npj Parkinsons Dis.

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To elucidate the biomarkers related to survival in multiple system atrophy(MSA), we analyzed the predictability of retrospectively collected blood markers for survival in 650 probable MSA. High absolute neutrophil count, red-cell distribution width, C-reactive protein, erythrocyte sedimentation rate, and low hemoglobin, protein, albumin, and creatinine were correlated with higher mortality in MSA. Systemic alteration in inflammation and nutritional status in the early stage are associated with higher mortality in MSA.

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supporting

confidence: 92%

Laboratory prognostic factors for the long-term survival of multiple system atrophy

Shin

Kim

Lee

et al. 2022

npj Parkinsons Dis.

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“…The modifying effect of living near blue space was calculated from the difference in both effects and risks between models. We used the concordance index (C-index) to evaluate the accuracy of the prognostic ability and reliability of our models; C-index > 0.70 indicates good prognostic ability of a model 41 . We performed log-rank tests and Akaike information criterion (AIC) comparisons to test for improvement of goodness-of-fit between models.…”

Section: Methodsmentioning

confidence: 99%

A population-based retrospective study of the modifying effect of urban blue space on the impact of socioeconomic deprivation on mental health, 2009–2018

Georgiou

Tieges

Morison

et al. 2022

Sci Rep

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The incidence of mental health disorders in urban areas is increasing and there is a growing interest in using urban blue spaces (urban waterways, canals, lakes, ponds, coasts, etc.) as a tool to manage and mitigate mental health inequalities in the population. However, there is a dearth of longitudinal evidence of the mechanisms and impact of blue spaces on clinical markers of mental health to support and inform such interventions. We conducted a 10-year retrospective study, following STROBE guidelines, using routinely collected population primary care health data within the National Health Service (NHS) administrative area of Greater Glasgow and Clyde for the North of Glasgow city area. We explored whether living near blue space modifies the negative effect of socio-economic deprivation on mental health during the regeneration of an urban blue space (canal) from complete dereliction and closure. A total of 132,788 people (65,351 female) fulfilling the inclusion criteria were entered in the analysis. We established a base model estimating the effect of deprivation on the risk of mental health disorders using a Cox proportional hazards model, adjusted for age, sex and pre-existing comorbidities. We then investigated the modifying effect of living near blue space by computing a second model which included distance to blue space as an additional predicting variable and compared the results to the base model. Living near blue space modified the risk of mental health disorders deriving from socio-economic deprivation by 6% (hazard ratio 2.48, 95% confidence interval 2.39–2.57) for those living in the most deprived tertile (T1) and by 4% (hazard ratio 1.66, 95% confidence interval 1.60–1.72) for those in the medium deprivation tertile (T2). Our findings support the notion that living near blue space could play an important role in reducing the burden of mental health inequalities in urban populations.

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“…The NLR in the peripheral blood is altered in various neurodegenerative disorders, such as ALS, MAS, AD and PD [ 8 , 9 , 31 , 32 ]. In cerebrovascular disorders such as stroke, NLR was also found to be associated with prognosis as well as mortality outcomes [ 33 , 34 ].…”

Section: Discussionmentioning

confidence: 99%

Neutrophil to High-density Lipoprotein ratio (NHR) as a potential predictor of disease severity and survival time in Creutzfeldt-Jakob disease

et al. 2023

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Introduction Creutzfeldt-Jakob disease (CJD) is a fatal and irreversible neurodegenerative disease. Identification of inexpensive and easy-to-implement biomarkers of CJD which could predict disease severity and patient survival is important for improving disease management. The aim of this study was to assess the predictive value of peripheral neutrophil to lymphocyte ratio (NLR), high-density lipoprotein (HDL), monocyte to HDL ratio (MHR) and neutrophil to HDL ratio (NHR) for CJD. Methods Patients with definite or probable CJD admitted to the Neurology Department of Xuanwu Hospital from 2014 to 2021 were enrolled and followed up until April 2022. Clinical information including sex, age, Barth Index, survival time and results of auxiliary examination were collected, and NLR, HDL, NHR and MHR were measured for all enrolled patients. The associations between NLR, HDL, NHR and MHR, and disease severity (evaluated by Barth Index), survival time and auxiliary examinations were evaluated. Results A total of 88 CJD patients were enrolled and all were deceased. NLR (r = -0.341, p = 0.001), NHR (r = -0.346, p = 0.001) and MHR (r = -0.327, p = 0.002) were significantly associated with disease severity. Higher NHR (HR = 2.344, 95% CI = 1.277–4.303 p = 0.006) and lower HDL (HR = 0.567, 95% CI = 0.346–0.930, p = 0.025) were associated with shorter survival time in the CJD patients. Conclusions Peripheral inflammatory biomarkers, especially NHR, were associated with disease severity and survival duration. These findings provide new insights into the mechanisms and treatment strategies of CJD.

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High neutrophil-to-lymphocyte ratio predicts short survival in multiple system atrophy

Cited by 23 publications

References 25 publications

Laboratory prognostic factors for the long-term survival of multiple system atrophy

Laboratory prognostic factors for the long-term survival of multiple system atrophy

A population-based retrospective study of the modifying effect of urban blue space on the impact of socioeconomic deprivation on mental health, 2009–2018

Neutrophil to High-density Lipoprotein ratio (NHR) as a potential predictor of disease severity and survival time in Creutzfeldt-Jakob disease

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