High normal plasma triglycerides are associated with preserved cognitive function in Chinese oldest-old

Yin, Zhaoxue; Shi, Xiaoming; Kraus, Virginia B.; Fitzgerald, Simon Michael; Qian, Han-Zhu; Xu, Jianwei; Zhai, Yali; Sereny, Melanie; Yi, Zhengfang

doi:10.1093/ageing/afs033

Cited by 77 publications

(76 citation statements)

References 29 publications

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“…Further, in a 26 year follow-up study of elderly, serum cholesterol levels decreased in elderly who developed mild cognitive impairment, while increased in those who maintained normal cognition in Asian elderly (12). Moreover, our previous study found a significant association between high normal plasma TG and preserved cognitive function in the Chinese oldest old (13), which was also confirmed in this study. There was also emerging evidence that cholesterol-lowering therapy was associated with some adverse effects on cognitive function in rodents (27) and human (28).…”

Section: Discussionsupporting

confidence: 88%

“…In addition, previous research indicated that higher consumption of tea, which is linked to lower cholesterol level, was proved to take a protective effect on cognition (7), and higher cholesterol was linked to faster cognitive decline among patients with Alzheimer's disease (8). In contrast, other studies provide contradictory findings that demonstrated no association between cholesterol concentrations and cognitive impairment or dementia (9,10), and even that higher concentrations of cholesterol were associated with a decreased risk of cognitive impairment among the elderly (11)(12)(13)(14)(15)(16).…”

Section: Introductionmentioning

confidence: 99%

“…Most of the existing studies only focused on the total population (4,5,(8)(9)(10)(11)(12)(13)(14)(15)(16); therefore, there is still some ambiguity with respect to potential differences in the relationships of cognition and lipids in men and women. Although the association between cholesterol and cognitive function is strongly age-dependent (17), yet few of previous studies focused on the oldest old (13).…”

Section: Introductionmentioning

confidence: 99%

“…Although the association between cholesterol and cognitive function is strongly age-dependent (17), yet few of previous studies focused on the oldest old (13). In an attempt to better understand the relationship between cholesterol and risk of cognitive impairment, a cross-sectional study was conducted among the 2000 Chinese elderly in 2012.…”

Section: Introductionmentioning

confidence: 99%

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Serum cholesterol levels within the high normal range are associated with better cognitive performance among Chinese elderly

Yin

Chei

et al. 2016

The Journal of nutrition, health and aging

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Objectives-The association between cognitive function and cholesterol levels is poorly understood and inconsistent results exist among the elderly. The purpose of this study is to investigate the association of cholesterol level with cognitive performance among Chinese elderly.Design-A cross-sectional study was implemented in 2012 and data were analyzed using generalized additive models, linear regression models and logistic regression models. Conflict of interestThe authors declare that there are no conflicts of interests. Ethical standardsThe authors declare that all the experiments of this study complied with the current laws of China in which they were performed. HHS Public Access Author Manuscript Author ManuscriptAuthor Manuscript Author ManuscriptSetting-Community-based setting in eight longevity areas in China.Subjects-A total of 2000 elderly aged 65 years and over (mean 85.8±12.0 years) participated in this study. Measurements-Total cholesterol (TC), triglycerides (TG), low density lipoprotein cholesterol (LDL-C) and high density lipoprotein cholesterol (HDL-C) concentration were determined and cognitive impairment was defined as Mini-Mental State Examination (MMSE) score≤23.Results-There was a significant positive linear association between TC, TG, LDL-C, HDL-C and MMSE score in linear regression models. Each 1 mmol/L increase in TC, TG, LDL-C and HDL-C corresponded to a decreased risk of cognitive impairment in logistic regression models. Compared with the lowest tertile, the highest tertile of TC, LDL-C and HDL-C had a lower risk of cognitive impairment. The adjusted odds ratios and 95% CI were 0.73(0.62-0.84) for TC, 0.81(0.70-0.94) for LDL-C and 0.81(0.70-0.94) for HDL-C. There was no gender difference in the protective effects of high TC and LDL-C levels on cognitive impairment. However, for high HDL-C levels the effect was only observed in women. High TC, LDL-C and HDL-C levels were associated with lower risk of cognitive impairment in the oldest old (aged 80 and older), but not in the younger elderly (aged 65 to 79 years).Conclusions-These findings suggest that cholesterol levels within the high normal range are associated with better cognitive performance in Chinese elderly, specifically in the oldest old. With further validation, low cholesterol may serve a clinical indicator of risk for cognitive impairment in the elderly.

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Section: Discussionsupporting

confidence: 88%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Serum cholesterol levels within the high normal range are associated with better cognitive performance among Chinese elderly

Yin

Chei

et al. 2016

The Journal of nutrition, health and aging

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“…Leisure activities included growing flowers, raising pets, reading books, playing cards, watching TV and listening to the radio, it was defined as ‘yes’ if the frequency of any item above is once per week or more. Social activities included support of housekeeping and taking part in organized social activities, and it was defined in the same way with leisure activities (18). Resilience was assessed by a simplified resilience score emphasizing coping and adjusting among the elderly and reflecting personal tenacity, optimism, coping with negative mood, secure relationship, and self-control (20), with the higher scores reflecting greater resilience, and higher resilience defined as a score ≥16.…”

Section: Methodsmentioning

confidence: 99%

Dietary diversity and cognitive function among elderly people: A population-based study

Yin

Fei

Qiu

et al. 2017

The Journal of nutrition, health and aging

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Objectives To explore associations of dietary diversity with cognitive function among Chinese elderly. Design This cross-sectional study was conducted in 2011–2012, data were analyzed using multiple linear regression and logistic regression models. Setting community-based setting in the 23 provinces in China. Subjects 8,571 elderly participants, including 2984 younger elderly aged 65–79 and 5587 oldest old aged 80+ participated in this study. Measurement Intake frequencies of food groups was collected and dietary diversity (DD) was assessed based on the mean of DD score. Cognitive function was assessed using the Chinese version of Mini-Mental State Examination (MMSE), and cognitive impairment was defined using education-based cutoffs. Information about socio-demographics, lifestyles, resilience and health status was also collected. Results Poor dietary diversity was significantly associated with cognitive function, with β (95% CI) of −0.11(−0.14, −0.08) for − log 31-MMSE score) and odds ratio (95% CI) of 1.29 (1.14, 1.47) for cognitive impairment. Interaction effect of age with DD was observed on cognitive impairment (P interaction=0.018), but not on −log 31-MMSE score) (P interaction=0.08). Further separate analysis showed that poor DD was significantly associated with increased risk of cognitive impairment in the oldest old (p<0.01), with odds ratio (95% CI) of 1.34 (1.17, 1.54), while not in the younger elderly (p>0.05), with OR (95% CI) being 1.09 (0.80, 1.47) in the fully adjusted model. Similar results were obtained when DD was categorized into four groups. Conclusions Poor dietary diversity was associated with worse global cognitive function among Chinese elderly, and particularly for the oldest old. This finding would be very meaningful for prevention of cognitive impairment.

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Research advances in the influence of lipid metabolism on cognitive impairment

Zhang

Zhu

2022

Ibrain

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Cognitive impairment (CI) is a mental disorder related to cognition and understanding, which is mainly categorized into mild CI and senile dementia. This disease is associated with multiple factors, such as chronic brain injury, aging, chronic systemic disease, mental state, and psychological factors. However, the pathological mechanism of CI remains unclear; it is usually associated with such underlying diseases as diabetes and hyperlipidemia. It has been demonstrated that abundant lipid metabolism indexes in the human body are closely related to CI, including total cholesterol, high‐density lipoprotein cholesterol, low‐density lipoprotein cholesterol, triglycerides, apolipoprotein, and so forth. As a crucial risk factor for CI, hyperlipidemia is of great significance in the occurrence and development of CI. However, the specific correlation between dyslipidemia and CI is still not fully elucidated. Besides, the efficacy of lipid‐lowering drugs in the prophylaxis and treatment of CI has not been clarified. In this study, relevant advances in the influence of lipid metabolism disorders in CI will be reviewed, in an attempt to explore the effect of mediating blood lipid levels on the prophylaxis and treatment of CI, thus providing a reference for its clinical management.

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High normal plasma triglycerides are associated with preserved cognitive function in Chinese oldest-old

Abstract: we concluded that high normal plasma triglyceride was associated with preservation of cognitive function while lower concentrations were not in the Chinese oldest-old.

Cited by 77 publications

References 29 publications

Serum cholesterol levels within the high normal range are associated with better cognitive performance among Chinese elderly

Serum cholesterol levels within the high normal range are associated with better cognitive performance among Chinese elderly

Dietary diversity and cognitive function among elderly people: A population-based study

Research advances in the influence of lipid metabolism on cognitive impairment

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