High Nutritional Risk Is Associated with Poor Functional Status and Prognostic Biomarkers in Stroke Patients at Admission to a Rehabilitation Unit

Di Vincenzo, Olivia; Pagano, Ermenegilda; Cervone, Mariarosaria; Natale, Raffaele; Morena, Annadora; Esposito, Alessandra; Pasanisi, Fabrizio; Scalfi, Luca

doi:10.3390/nu15194144

Cited by 13 publications

(8 citation statements)

References 36 publications

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“…Early identification and management of malnutrition can help improve outcomes and quality of life for stroke patients. Overall, the CONUT score serves as a valuable tool in the comprehensive care of stroke patients, helping healthcare providers address nutritional needs and optimize recovery [ 33 , 34 , 35 ].…”

Section: Discussionmentioning

confidence: 99%

The Relationship between Neutrophil–Lymphocyte Ratios with Nutritional Status, Risk of Nutritional Indices, Prognostic Nutritional Indices and Morbidity in Patients with Ischemic Stroke

Misirlioglu,

Uzun,

Ozen

et al. 2024

Nutrients

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Background: In recent years, whole blood parameters and derivatives have been used as prognostic criteria in the course of various diseases. The aim of this study was to evaluate the relationship between parameters such as the neutrophil–lymphocyte ratio (NLR), the systemic immune-inflammation index (SII), the prognostic nutritional index (PNI), controlling nutritional status (CONUT) score, nutritional risk index (NRI) and immunonutrition status and disease activity in patients with ischemic stroke of the small-vessel, large-vessel and other etiologies. Methods: We retrospectively evaluated the records of 1454 consecutive ischemic stroke patients hospitalized in the emergency department of Gaziosmanpasa Education and Research Hospital from 2019 to 2023. Results: Of the 1350 patients with ischemic stroke included in the study, 58.8% had small-vessel disease, 29.3% had large-vessel disease and 11.9% had other etiologies. There was a significant difference between the three etiology groups for PNI and CONUT. The mean of PNI was 47.30 ± 8.06 in the other etiology group, 37.25 ± 7.23 in the small-vessel group, and 34.78 ± 8.16 in the large-vessel disease group. The mean of CONUT was 5.49 ± 1.20 in the small-vessel group, 5.12 ± 1.46 in the large-vessel group and 4.22 ± 1.11 in the other etiology group. In addition, CONUT and PNI were also found to be independent risk factors for mortality. A negative significant correlation was observed between PNI and NLR (r: −0.692), SII (r: −0.591), and CONUT (r: −0.511). Significant correlations were observed between CONUT and NLR (r: 0.402), SII (r: 0.312). Conclusions: PNI, CONUT and NRI were found as more accurate prognostic indicators of nutritional status in patients with ischemic stroke. NLR and SII may be important predictive markers in the course and prognosis of stroke.

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Section: Discussionmentioning

confidence: 99%

The Relationship between Neutrophil–Lymphocyte Ratios with Nutritional Status, Risk of Nutritional Indices, Prognostic Nutritional Indices and Morbidity in Patients with Ischemic Stroke

Misirlioglu,

Uzun,

Ozen

et al. 2024

Nutrients

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“…This review emphasizes the pivotal role of nutrition in shaping functional outcomes during stroke rehabilitation, a finding echoed across various studies. The research by Siotto et al [ 11 ], Sato et al [ 12 ], Irisawa and Mizushima [ 13 ], Ha et al [ 14 ], and Di Vincenzo et al [ 15 ] collectively illuminates the multifaceted impact of nutrition on post-stroke recovery pathways. Siotto et al [ 11 ] underscore the necessity of precise nutritional evaluations, stressing the potential benefits of omega-3 fatty acids on neuroplasticity, a notion supported by the findings of Spencer et al [ 4 ] and Hankey [ 6 ].…”

Section: Reviewmentioning

confidence: 99%

“…Di Vincenzo et al [ 15 ] bring attention to the high dietary risk in older stroke patients, showing a correlation between poorer functional outcomes and increased inflammation. This aligns with the growing evidence that nutritional risk is not just a matter of dietary intake but also a significant factor influencing the rehabilitation process, functional recovery, and overall prognosis.…”

Section: Reviewmentioning

confidence: 99%

Influence of Nutritional Interventions on Functional Outcomes in Stroke Rehabilitation: A Systematic Review

Kolanu,

Ahmed,

Kerimkulova

et al. 2024

Cureus

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Stroke, a major cause of disability worldwide, necessitates comprehensive rehabilitation, with nutrition playing a pivotal role in recovery. Our systematic review assesses the impact of nutritional interventions on stroke survivors' rehabilitation. Adhering to Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, we systematically searched PubMed, Embase, Web of Science, and Scopus, using keywords related to stroke rehabilitation and nutrition. Studies were selected based on criteria emphasizing dietary interventions and their effect on functional recovery in stroke patients. The review involved detailed data extraction and synthesis, covering study design, participant characteristics, interventions, and outcomes. Five studies met our inclusion criteria, encompassing longitudinal and prospective studies, retrospective cohorts, and randomized controlled trials. These studies highlighted the importance of early nutritional assessment, particularly for sarcopenic patients, and the role of energy and protein intake soon after a stroke. Findings indicated high nutritional risk correlated with poorer functional outcomes and increased inflammation. Tailored dietary support appeared beneficial for muscle mass maintenance and overall functional recovery, especially in older patients. Our review emphasizes the critical role of nutritional interventions in stroke rehabilitation. It suggests that personalized nutritional strategies can positively impact functional recovery, notably in older and nutritionally vulnerable stroke survivors. These insights underscore the necessity of integrating dietary assessments and interventions into standard stroke rehabilitation protocols, advocating a holistic approach to patient care.

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“…Despite the medical and socioeconomic heterogeneity in centenarians (including physical status, cognitive function, socioeconomic status, and cultural or historical background) they were described by Franceschi et al as a model of successful aging three decades ago [ 10 , 11 ]. Concomitantly, high nutritional risk was associated with functional status decline and with predictors of negative clinical outcomes [ 12 ]. Analysis of blood biochemistry and routine examinations of the quantitative and morphological changes in blood cells provide not only the biological characteristics estimating the function of organs but also constitute blood-based biomarkers of aging [ 13 , 14 , 15 ].…”

Section: Introductionmentioning

confidence: 99%

Association between Blood Parameters of Nutritional Status and Functional Status in Extreme Longevity

Kupisz-Urbanska,

Marcinowska-Suchowierska,

Jankowski

2024

Nutrients

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Background: The relationship between functional and nutritional status in the geriatric population remains an issue of debate and there is a gap in the knowledge regarding this field in long-lived individuals. Aim: The main aim of this study was to assess the association between selected blood parameters of nutritional status and functional status in extreme longevity. Methods: The inclusion criteria were centenarians above 100 years of age who were examined at their homes, and blood samples were collected. The study group consisted of 170 individuals (25 men and 145 women, median age 100.75 years [100.29–101.58]). Results: Total protein and albumin serum concentration was significantly lower in long-lived individuals with severe functional decline compared to individuals with preserved functional status, p = 0.000001 and p = 0.0000, respectively. Iron serum level was significantly higher in the group with preserved functional status, p = 0.04. Preserved functional status was positively correlated with total protein serum concentration (p = 0.000), albumin concentration (p = 0.000), and iron serum level (p = 0.029). A negative correlation was stated between c-reactive protein (CRP) and functional status (p = 0.032). Univariable logistic regression analysis showed that the functional status of long-lived individuals depends on total protein (OR 2.89, CI 95% [1.67–5.0]) and albumin concentrations (OR 2.34, CI 95% [1.39–3.92]). Multivariable backward stepwise logistic regression analysis showed that a total protein concentration was the only variable independently related to the preserved functional status (OR 3.2, 95% Cl [1.8–5.67]). Conclusions: In long-lived individuals, the total serum protein and albumin levels are lower in centenarians with severe functional decline, and they correlate with functional status. Total protein serum concentration is the only factor independently related to the preserved functional status in extreme longevity.

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High Nutritional Risk Is Associated with Poor Functional Status and Prognostic Biomarkers in Stroke Patients at Admission to a Rehabilitation Unit

Cited by 13 publications

References 36 publications

The Relationship between Neutrophil–Lymphocyte Ratios with Nutritional Status, Risk of Nutritional Indices, Prognostic Nutritional Indices and Morbidity in Patients with Ischemic Stroke

The Relationship between Neutrophil–Lymphocyte Ratios with Nutritional Status, Risk of Nutritional Indices, Prognostic Nutritional Indices and Morbidity in Patients with Ischemic Stroke

Influence of Nutritional Interventions on Functional Outcomes in Stroke Rehabilitation: A Systematic Review

Association between Blood Parameters of Nutritional Status and Functional Status in Extreme Longevity

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