High perceived stress in women is linked to oxidation, inflammation and immunosenescence

Toda, Irene Martínez de; Miguélez, Lara; Siboni, León; Vida, Carmen; Fuente, Mónica De la

doi:10.1007/s10522-019-09829-y

Cited by 27 publications

(14 citation statements)

References 51 publications

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“…However, if the individual perceives a noxious stimulus as too intense, or its duration as too long, they may fail to cope with it, maladaptation occurs, neuroimmunoendocrine parameters remain altered, accelerating the rate of aging and the appearance of age-related diseases [4,85,86]. In accordance with this, there are several examples in which chronic stress situations were associated with a defective immune functional capacity [87][88][89] and with accelerated aging [4,90]. In addition, our research group has a wide experience analyzing the relationship between the response to a stressful situation and longevity in mice.…”

Section: Lifestyle Situations Modulating the Rate Of Aging: Friends Or Foes?mentioning

confidence: 91%

The Role of Immune Cells in Oxi-Inflamm-Aging

Toda

Ceprián

Cerro

et al. 2021

Cells

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Aging is the result of the deterioration of the homeostatic systems (nervous, endocrine, and immune systems), which preserve the organism’s health. We propose that the age-related impairment of these systems is due to the establishment of a chronic oxidative stress situation that leads to low-grade chronic inflammation throughout the immune system’s activity. It is known that the immune system weakens with age, which increases morbidity and mortality. In this context, we describe how the function of immune cells can be used as an indicator of the rate of aging of an individual. In addition to this passive role as a marker, we describe how the immune system can work as a driver of aging by amplifying the oxidative-inflammatory stress associated with aging (oxi-inflamm-aging) and inducing senescence in far tissue cells. Further supporting our theory, we discuss how certain lifestyle conditions (such as social environment, nutrition, or exercise) can have an impact on longevity by affecting the oxidative and inflammatory state of immune cells, regulating immunosenescence and its contribution to oxi-inflamm-aging.

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Section: Lifestyle Situations Modulating the Rate Of Aging: Friends Or Foes?mentioning

confidence: 91%

The Role of Immune Cells in Oxi-Inflamm-Aging

Toda

Ceprián

Cerro

et al. 2021

Cells

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“…Biological age is dependent on genes, but in a higher proportion on the environment and life style [14]. The hormonal response to stress is one of the factors involved in this rate of aging [15,16]. In fact, the adequate hormonal adaptation to stress situations is one of the hallmarks of health [17].…”

Section: Introductionmentioning

confidence: 99%

Improvement of several stress response and sleep quality hormones in men and women after sleeping in a bed that protects against electromagnetic fields

et al. 2022

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Background The electromagnetic fields (EMFs) emitted by the technologies affect the homeostatic systems (nervous, endocrine, and immune systems) and consequently the health. In a previous work, we observed that men and women, after 2 months of using a bed with a registered HOGO system, that prevents and drain EMFs, improved their immunity, redox and inflammatory states and rejuvenated their rate of aging or biological age. Since, EMFs can act as a chronic stressor stimulus, and affect the sleep quality. The objective of this work was to study in men and women (23–73 years old) the effect of sleeping for 2 months on that bed in the blood concentrations of several hormones related to stress response and sleep quality as well as to corroborate the rejuvenation of their biological age. Methods In 18 men and women, plasma concentration of cortisol, dehydroepiandrosterone (DHEA), catecholamines (epinephrine, norepinephrine and dopamine), serotonin, oxytocin and melatonin were analyzed before and after 2 months of using the HOGO beds. A group of 10 people was used as placebo control. In another cohort of 25 men (20 experimental and 5 placebo), the effects of rest on the HOGO system on the concentration of cortisol and testosterone in plasma were studied. In all these volunteers, the biological age was analyzed using the Immunity Clock model. Results There is a significant increase in plasma concentration of DHEA, norepinephrine, serotonin, oxytocin, and melatonin as well as in testosterone, after resting for 2 months in that bed with the EMFs avoiding system. In addition, decreases in Cortisol/DHEA and Testosterone/cortisol ratio and plasma dopamine concentration were observed. No differences were found in placebo groups. In all participants that slept on HOGO beds, the biological age was reduced. Conclusions Sleeping in a bed that isolates from EMFs and drain them can be a possible strategy to improve the secretion of hormones related to a better response to stress and sleep quality, which means a better endocrine system, and consequently better homeostasis and maintenance of health. This fact was confirmed with the slowdown in the rate of aging checked with a rejuvenation of the biological age.

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“…In addition, a positive correlation was found between how they perceived the stress situation and their biological age (Ref. 15).…”

Section: Introductionmentioning

confidence: 99%

Social environment as a modulator of immunosenescence

Garrido

Toda

Cerro

et al. 2022

Expert Rev. Mol. Med.

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Immune system aging, a process known as immunosenescence, involves a striking rearrangement affecting all immune cells, resulting in an increased rate of infections and a major incidence of autoimmune diseases and cancer. Nonetheless, differences in how individuals of the same chronological age carry out this immunosenescence establishment and thus the aging rate have been reported. In the context of neuroimmunoendocrine communication and its role in the response to stress situations, growing evidence suggests that social environments profoundly influence all physiological responses, especially those linked to immunity. Accordingly, negative contexts (loneliness in humans/social isolation in rodents) were associated with immune impairments and decreased lifespan. However, positive social environments have been correlated with adequate immunity and increased lifespan. Therefore, the social context in which an individual lives is proposed as a decisive modulator of the immunosenescence process and, consequently, of the rate of aging. In this review, the most important findings regarding how different social environments (negative and positive) modulate immunosenescence and therefore the aging rate, as well as the role of stress responses, hormesis, and resilience in these environments will be explained. Finally, several possible molecular mechanisms underlying the effects of negative and positive environments on immunosenescence will be suggested.

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High perceived stress in women is linked to oxidation, inflammation and immunosenescence

Cited by 27 publications

References 51 publications

The Role of Immune Cells in Oxi-Inflamm-Aging

The Role of Immune Cells in Oxi-Inflamm-Aging

Improvement of several stress response and sleep quality hormones in men and women after sleeping in a bed that protects against electromagnetic fields

Social environment as a modulator of immunosenescence

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