High-performance bilayer composites for the replacement of osteochondral defects

Oliveira, Andreia S. R.; Silva, João; Figueiredo, Lígia; Ferreira, Frederico Castelo; Kotov, Nicholas A.; Colaço, R.; Serro, Ana Paula

doi:10.1039/d2bm00716a

Cited by 5 publications

(2 citation statements)

References 101 publications

(260 reference statements)

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“…PVA hydrogels reinforced with PBO fibres were synthesized according to a protocol described previously [ 20 , 57 ]. Briefly, PVA (6% w / v ) was dissolved in pure TFA, while PBO fibres (1% w / v ) were added to a mixture of 80% TFA and 20% MSA solution.…”

Section: Methodsmentioning

confidence: 99%

Effects of Non-Conventional Sterilisation Methods on PBO-Reinforced PVA Hydrogels for Cartilage Replacement

Pires

Oliveira

Marques

et al. 2022

Gels

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Articular cartilage (AC) degradation is a recurrent pathology that affects millions of people worldwide. Polyvinyl alcohol (PVA) hydrogels have been widely explored for AC replacement. However, their mechanical performance is generally inadequate, and these materials need to be reinforced. Moreover, to be used in a clinical setting, such materials must undergo effective sterilisation. In this work, a PVA hydrogel reinforced with poly(p-phenylene-2,6-benzobisoxazole) (PBO) nanofibres was submitted to three non-conventional sterilisation methods: microwave (MW), high hydrostatic pressure (HHP), and plasma (PM), in order to evaluate their impact on the properties of the material. Sterilisation was achieved in all cases. Properties such as water content and hydrophilicity were not affected. FTIR analysis indicated some changes in crystallinity and/or crosslinking in all cases. MW was revealed to be the most suitable method, since, unlike to PM and HHP, it led to a general improvement of the materials’ properties: increasing the hardness, stiffness (both in tensile and compression), and shear modulus, and also leading to a decrease in the coefficient of friction against porcine cartilage. Furthermore, the samples remained non-irritant and non-cytotoxic. Moreover, this method allows terminal sterilisation in a short time (3 min) and using accessible equipment.

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Section: Methodsmentioning

confidence: 99%

Effects of Non-Conventional Sterilisation Methods on PBO-Reinforced PVA Hydrogels for Cartilage Replacement

Pires

Oliveira

Marques

et al. 2022

Gels

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show abstract

“…The traumatology science currently develops two fundamentally different approaches to address injuries and bone loss: 1) simple replacement of a damaged area of the bone with a massive implant, with or without bioengineered structure, that replaces the bone and adjacent joints, or 2) creating conditions for regeneration of the bone in the injured area with an osteoinductive (absorbable or non-absorbable) implant. An analysis of literature reveals that both directions are increasingly associated with bioceramics, the use of which in medicine has been expanding as the developments in the field of chemistry progress and technologies for production of materials with the properties that are close to bone tissue improve [34][35][36].…”

Section: обзор литературыmentioning

confidence: 99%

Biocompatible implants in orthopedics: bone tissue engineering

Popkov,

Popkov

2023

jour

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Introduction Technological advances in bone tissue engineering have improved orthopaedic implants and surgical techniques for bone reconstruction. This approach allows overcoming inconvenience of the paucity of autologous materials available and donor site morbidity.Aim To demonstrate advances of the past 30 years in the development of bioimplants providing alternatives to bone grafting in reconstructive orthopaedics.Methods Preparing the review, the scientific platforms such as PubMed, Scopus, ResearchGate, RSCI were used for information searching. Search words or word combinations were bioactive osteoinductive implants, bone grafting, bone reconstruction, hydroxyapatite, bone scaffolds.Results The main trends in tissue engineering in the field of orthopaedics are represented by construction of three-dimensional structure implants guiding cell migration, proliferation and differentiation as well as mechanical support. Association with bone morphogenetic proteins, growth factors enables proliferation and differentiation of cell types of the targeted bone tissue. A promising advancement should be biodegradability with a controllable degradation rate to compliment cell/tissue in-growth and maturation in limb reconstruction.Discussion This review presents and discusses the experimental and clinical application of biotolerant, bioinert and bioactive materials for reconstructive bone surgery. Future generations of biomaterials are designed to be osteoconductive and osteoinductive.Conclusion Properties of polycaprolactone (PCL) filled with hydroxyapatite (from 10 to 50 wt %) make this hybrid material with controllable absorption a promising strategy for reconstructive surgery in comparison to other materials.

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Microstructurally and mechanically tunable acellular hydrogel scaffold using carboxymethyl cellulose for potential osteochondral tissue engineering

Gong,

Zhang,

Liu

et al. 2023

International Journal of Biological Macromolecules

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High-performance bilayer composites for the replacement of osteochondral defects

Abstract: Osteochondral (OC) defects combine damage to cartilage and subchondral bone, posing a significant challenge to their repair due to the dissimilar characteristics and regenerative capabilities between the two tissues. Here,...

Cited by 5 publications

References 101 publications

Effects of Non-Conventional Sterilisation Methods on PBO-Reinforced PVA Hydrogels for Cartilage Replacement

Effects of Non-Conventional Sterilisation Methods on PBO-Reinforced PVA Hydrogels for Cartilage Replacement

Biocompatible implants in orthopedics: bone tissue engineering

Microstructurally and mechanically tunable acellular hydrogel scaffold using carboxymethyl cellulose for potential osteochondral tissue engineering

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