High-performance blood plasma separation based on a Janus membrane technique and RBC agglutination reaction

Abstract

Separation of Plasma where full of various biomarkers is critical for clinical diagnosis. However, the point-of-care plasma separation often relies on microfluidic filtration membranes, which are usually limited in purity,...

Designing Janus Two-Dimensional Porous Materials for Unidirectional Transport: Principles, Applications, and Challenges

“…Xu et al further integrated blood plasma separation with a red blood cell agglutination reaction for subsequent clinical diagnosis using a Janus membrane on a microhole array. 103 This combination enables the extraction of highly purified plasma, achieving a 99.99% purity from whole blood, with an ultrahigh plasma yield of approximately 80%.…”

“…Jin et al proposed a rapid blood separation method using a Janus membrane. , The membrane facilitates rapid unidirectional liquid transport from the hydrophobic side to the hydrophilic side while effectively rejecting large red blood cells through its pores. Xu et al further integrated blood plasma separation with a red blood cell agglutination reaction for subsequent clinical diagnosis using a Janus membrane on a microhole array . This combination enables the extraction of highly purified plasma, achieving a 99.99% purity from whole blood, with an ultrahigh plasma yield of approximately 80%.…”

Tailored Micromagnet Sorting Gate for Simultaneous Multiple Cell Screening in Portable Magnetophoretic Cell‐On‐Chip Platforms

“…Cell‐on‐chip technology is being developed to be user‐friendly and accessible, even for individuals without technical expertise. Researchers have explored various techniques in cell diagnosis, such as enzyme‐linked immunosorbent assay involving antigen‐antibody binding technology, [ 4 ] filter technology using microfilters [ 5 ] and micropores [ 6 ] in microfluidic structures, electrophoresis, [ 4b,7 ] Dielectrophoresis, [ 8 ] acoustophoresis, [ 9 ] and magnetophoresis, [ 10 ] to achieve portable cell analysis devices with high sensitivity and fast analysis speed. However, despite these advances, the ability to effectively manipulate individual cells is limited and remains a challenge for portable cellular analyses.…”