High-Performance FET-Based Dopamine-Sensitive Biosensor Platform Based on SOI Substrate

Abstract

Dopamine is a catecholamine neurotransmitter that plays a significant role in the human central nervous system, even at extremely low concentrations. Several studies have focused on rapid and accurate detection of dopamine levels using field-effect transistor (FET)-based sensors. However, conventional approaches have poor dopamine sensitivity with values <11 mV/log [DA]. Hence, it is necessary to increase the sensitivity of FET-based dopamine sensors. In the present study, we proposed a high-performance dopamine-sensitive biosensor platform based on dual-gate FET on a silicon-on-insulator substrate. This proposed biosensor overcame the limitations of conventional approaches. The biosensor platform consisted of a dual-gate FET transducer unit and a dopamine-sensitive extended gate sensing unit. The capacitive coupling between the top- and bottom-gate of the transducer unit allowed for self-amplification of the dopamine sensitivity, resulting in an increased sensitivity of 373.98 mV/log[DA] from concentrations 10 fM to 1 μM. Therefore, the proposed FET-based dopamine sensor is expected to be widely applied as a highly sensitive and reliable biosensor platform, enabling fast and accurate detection of dopamine levels in various applications such as medical diagnosis and drug development.

Enhanced BSA Detection Precision: Leveraging High-Performance Dual-Gate Ion-Sensitive Field-Effect-Transistor Scheme and Surface-Treated Sensing Membranes

“…To address these challenges, we propose an alternative dual-gate field-effect transistor (DG-FET)-based BSA-detection biosensor platform. To enhance its detection capabilities, we utilized a dual-gate (DG) structure and capacitive coupling effects [ 26 , 27 , 28 , 29 , 30 , 31 ]. The capacitive coupling effect is determined by the capacitance ratio between the top-gate (TG) oxide and the bottom-gate (BG) oxide and achieves high sensitivity without requiring additional circuits, owing to its inherent amplification effect.…”

From Enzymatic Dopamine Biosensors to OECT Biosensors of Dopamine

“…To detect small molecules of analytes, like DA, several solid-state devices were developed. The first representative was the Ion-Sensitive Field-Effect Transistor (ISFET) [ 35 ]. Then these successively followed: electrolyte-insulator-semiconductor (EIS) [ 36 ], organic thin film transistor (OTFT) [ 37 ], Organic Electrochemical Transistor (OECT) [ 38 ], and extended-gate field-effect transistor (EGFET) [ 39 ].…”