High-performance liquid chromatographic analysis of griseofulvin in drug substance and solid dosage forms: Separation of impurities and metabolites

Townley, Edward R.; Roden, Paul

doi:10.1002/jps.2600690512

Cited by 12 publications

(5 citation statements)

References 14 publications

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“…The method was modified from Townley and Roden. 16 Isothermal Crystallization above the Glass Transition Temperature. About 10 mg of crystalline griseofulvin powder was packed into a hermetically sealed DSC pan, and heated until molten.…”

Section: Methodsmentioning

confidence: 99%

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Thermodynamics, Molecular Mobility and Crystallization Kinetics of Amorphous Griseofulvin

et al. 2008

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Griseofulvin is a small rigid molecule that shows relatively high molecular mobility and small configurational entropy in the amorphous phase and tends to readily crystallize from both rubbery and glassy states. This work examines the crystallization kinetics and mechanism of amorphous griseofulvin and the quantitative correlation between the rate of crystallization and molecular mobility above and below Tg. Amorphous griseofulvin was prepared by rapidly quenching the melt in liquid N2. The thermodynamics and dynamics of amorphous phase were then characterized using a combination of thermal analysis techniques. After characterization of the amorphous phase, crystallization kinetics above Tg were monitored by isothermal differential scanning calorimetry (DSC). Transformation curves for crystallization fit a second-order John-Mehl-Avrami (JMA) model. Crystallization kinetics below Tg were monitored by powder X-ray diffraction and fit to the second-order JMA model. Activation energies for crystallization were markedly different above and below Tg suggesting a change in mechanism. In both cases molecular mobility appeared to be partially involved in the rate-limiting step for crystallization, but the extent of correlation between the rate of crystallization and molecular mobility was different above and below Tg. A lower extent of correlation below Tg was observed which does not appear to be explained by the molecular mobility alone and the diminishing activation energy for crystallization suggests a change in the mechanism of crystallization.

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Section: Methodsmentioning

confidence: 99%

“…The mobile phase consisted of water/methanol (65:35 v/v), which was pumped through a Zorbax CN column at a flow rate of 1.0 mL/min. The method was modified from Townley and Roden …”

Section: Methodsmentioning

confidence: 99%

Thermodynamics, Molecular Mobility and Crystallization Kinetics of Amorphous Griseofulvin

et al. 2008

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“…Griseofulvin (CAS: 126-07-8) is a pharmaceutical with powerful antifungal action; its chemical structure is shown in Figure . It was prepared by fermentation, extraction, concentration, crystallization, and recrystallization. , At present, we were investigating and improving griseofulvin production technology, such as extraction, crystallization, and recrystallization . We found the solubility of griseofulvin extremely important for the optimal unit operation conditions.…”

Section: Introductionmentioning

confidence: 99%

Measurement and Correlation of Griseofulvin Solubility in Different Solvents at Temperatures from (281.95 to 357.60) K

Wang

et al. 2010

J. Chem. Eng. Data

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“…For instance, iodometric titration (12)(13)(14)(15) cannot be applied to penicillins having unsaturated side chains. A microtitration method ( 1 0 , l l ) has been applied to broth.…”

Section: Discussionmentioning

confidence: 99%

Simultaneous Assay of Hydrocodone Bitartrate and Acetaminophen in a Tablet Formulation

Wallo

D’adamo

1982

Journal of Pharmaceutical Sciences

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High-performance liquid chromatographic analysis of griseofulvin in drug substance and solid dosage forms: Separation of impurities and metabolites

Cited by 12 publications

References 14 publications

Thermodynamics, Molecular Mobility and Crystallization Kinetics of Amorphous Griseofulvin

Thermodynamics, Molecular Mobility and Crystallization Kinetics of Amorphous Griseofulvin

Measurement and Correlation of Griseofulvin Solubility in Different Solvents at Temperatures from (281.95 to 357.60) K

Simultaneous Assay of Hydrocodone Bitartrate and Acetaminophen in a Tablet Formulation

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