High-Performance Liquid Chromatographic Analysis of Nadolol and Bendroflumethiazide Combination Tablet Formulations

Perlman, Solomon; Szyper, Mira; Kirschbaum, Joel

doi:10.1002/jps.2600730230

Cited by 10 publications

(4 citation statements)

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“…This recovery is found to compare favorably with some HPLC methods previously reported for nadolol. The HPLC method of Patel et al [9] gave recoveries of 100.4 and 100.6% while that of Perlman et al [11] using phenyl column gave recoveries of 99.4% (RSD 0.4%) for nadolol. When compared to other previously described colorimetric methods, the new method described in this work is found to provide the advantages of high sensitivity, good accuracy and comparable reproducibility.…”

Section: Resultsmentioning

confidence: 99%

“…E-mail: jireade@yahoo.com combination with bendroflumethiazide.Nadolol has been assayed by non-aqueous titration [3,4], HPLC analysis in biological fluids [5,6], fluorimetry [7] as well as analysis of the enantiomers in human plasma [8]. The dosage form has been assayed using HPLC [4,9,10,11] and colorimetry using 2,4-dinitrophenylhydrazine after oxidation with periodic acid [12], extractive method in chloroform with bromophenol blue [13] and charge transfer complexation with 4-chloro-7-nitro-2,1,3-benzoxadiazole [14]. The majority of the methods based on colorimetry suffer from the disadvantage of poor detection limits, high calibration range and extensive extraction procedures.…”

Section: Introductionmentioning

confidence: 99%

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A new spectrophotometric method for the determination of nadolol

Adegoke

Olaniyi

2006

JICS

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A new spectrophotometric method has been developed for the assay of nadolol in pure form and in tablets. The assay procedure is based on a derivatization methodology employing 4-carboxyl-2,6-dinitrobenzene diazonium ion (CDNBD) as a diazo coupling reagent. The azo dye formed between nadolol and CDNBD absorbed visible light at the wavelength maximum of 416 nm ( max ) demonstrating a bathochromic shift from the absorption maximum of nadolol. Optimization studies established an optimal reaction time of 10 min at 60 o C. The assays were linear over 1.25-10 μg ml -1 of nadolol, and the reaction occurred by a 3:1 reagent/drug stoichiometric ratio. The method is found to be selective and has a lower detection limit of 0.29 μg ml -1 . Recovery studies over three days gave mean recovery of 101.4% (RSD 3.0%). This new method has been successfully applied in the determination of nadolol and nadolol/bendroflumethiazide tablets with accuracy and precision similar to the official (USP) HPLC procedure (p > 0.05). The new procedure has the advantages of high sensitivity, lower limit of detection and could find application as an in-process quality control method for nadolol.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

A new spectrophotometric method for the determination of nadolol

Adegoke

Olaniyi

2006

JICS

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“…The mobile phase was double-distilled water-methanol-phosphoric acid (80:20:0.05) at a flow rate of 2.0 mL/min, with detection at 210 nm. Details of the conditions used have been described previously (5).…”

Section: Methodsmentioning

confidence: 99%

Mechanism for the High Bias in the USP Colorimetric Assay for Diazotizable Substances in Hydrochlorothiazide

Sieh¹,

Perlman²

1984

Journal of Pharmaceutical Sciences

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“…Imatinib mesylate is a white crystalline powder distilled water, 0.1 N HCl, methanol, and dimethyl ether sparingly soluble [1]. Review of literature reveals that only a few methods such as ultraviolet (UV) [2][3][4][5][6][7], colorimetery [8,9], biological fluid using high-performance liquid chromatography (HPLC) [10], reversed phase-HPLC [3,[11][12][13], LC [14][15][16], LC-mass spectrometry [17] and ultrafast LC [18] were developed for the determination of imatinib mesylate in pure and pharmaceutical preparation.…”

Section: Imatinib Mesylate's Chemical Name Is 4-4[(4-methyl-1-piperazmentioning

confidence: 99%

Development of Analytical Method for Imatinib Mesylate by Ultraviolet Spectroscopy

Ajithkumar

2019

Asian J Pharm Clin Res

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Objective: A simple, selective, sensitive, specific, and spectrophotometric method has been developed for the detection of imatinib mesylate in pure form and formulations. Methods: The analytical condition was optimized for the drug, carried out as per the International Council for Harmonisation of Technical Requirements for Pharmaceuticals for Human Use guidelines. Results: The drug shows absorption at 232.0 nm and obeyed beers law in the wide concentration range from 0.5 to 4.0 μg/ml. The lower limit of detection was found to be 0.331 μg/ml and the limit of quantification to be 1.004 μg/ml. The regression equation was found to be y = 0.08x. The precision of the method was found to be 99.04%±0.527% and the percentage of drug recovered by this method is 100.13%±1.375%. Conclusion: The method is simple and suitable for determination for imatinib mesylate in pure and pharmaceutical preparation.

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High-Performance Liquid Chromatographic Analysis of Nadolol and Bendroflumethiazide Combination Tablet Formulations

Cited by 10 publications

References 4 publications

A new spectrophotometric method for the determination of nadolol

A new spectrophotometric method for the determination of nadolol

Mechanism for the High Bias in the USP Colorimetric Assay for Diazotizable Substances in Hydrochlorothiazide

Development of Analytical Method for Imatinib Mesylate by Ultraviolet Spectroscopy

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