High-performance liquid chromatographic analysis of chlorhexidine phosphanilate, a new antimicrobial agent

Polymeric multilayers that localize the release of chlorhexidine from biologic wound dressings

“…1 ). Two apparent pKa's have been reported for chlorhexidine: pKa 1 = 10.3, for the first two protonations, and pKa 2 = 2.2, for the 3 rd and 4 th protonations [42, 43]. Between pH 4 and 8, chlorhexidine is dicationic (charge of +2.0).…”

Drug catalyzed polymerization yields one pot nanomedicines

“…Chlorhexidine has 2 pairs of p K a values of its corresponding conjugate acids (10.3 and 2.2). 37 In contrast, the conjugate acid of TBD has p K a ≥ 19.4. 38 Due to the twofold symmetry of chlorhexidine, we predicted that chlorhexidine conjugation would either have 2 or 4 active acylation sites.…”