High-Performance Liquid Chromatographic and Derivative Difference Spectrophotometric Methods for the Determination of Acetaminophen and Its Degradation Product in Aged Pharmaceutical Formulations

Determination of paracetamol: Historical evolution

“…Therefore, it is very important to have an analytical technique for the measurement of PCT and its degradation product simply and precisely. A variety of high performance liquid chromatographic methods have been proposed for such measurement, using silica-based stationary phases [242][243][244]. These methods are time consuming in addition, the alkyl bonded silica-based stationary phases suffer from a number of drawbacks, including poor stability at extremes of pH and a variety of unwanted interactions due to surface heterogeneity.…”

Second order advantage obtained by spectroelectrochemistry along with novel carbon nanotube modified mesh electrode: Application for determination of acetaminophen in Novafen samples

“…The development of analytical techniques for rapid analysis of paracetamol is important for quality and medical control. Many methods have been described for determination of acetaminophen including electrochemistry [5,6], spectrophotometry [7,8], liquid chromatography (LC) [9], chemiluminescence [10,11], amperometric biosensors [12,13] and FTIR-spectrometry [14]. These proposed methods often require complicated operations of pretreatment or expensive instruments which prompt us to develop a chemometrics method for the determination of acetaminophen.…”

Stability‐indicating HPLC method for simultaneous quantification of 14 impurities in excedrin tablet formulations and identification of new impurity by LC–MS in accelerated stability studies

“…A literature survey revealed several analytical methods, mostly for the estimation of ACE, ASP and CAF using different analytical techniques. The details of such reports are as follows: ACE (Ali, Rafiuddin, & Ghori, ; Bloomfield, ; Hewala, ; Kamberi, Riley, & Ma Sharon, ; Kamyabi, ; Mohamed, AbdAllah, & Shammat, ; Nemeth, Jankovics, & Nemeth‐Palotas, ; Perez‐Ruiz, Martinez‐Lozano, & Tomas, ; Rao & Narasaraju, ; Wysecka‐Kaszuba, Warowna‐Grzes'kiewicz, & Fijalek, ); ASP (Akay, Degim, & Sayal, ; Kokot & Burda, ; Umapathi, Parirqoo, & Thomas, ; McMahon & Kelly, ); and CAF (Bruschettini, Barco, & Romantsik, ; Charles, Townsend, & Steer, ; Marın & Barbas, ; Zhang, Mehrotra, & Budha, ). None of the reported methods were based on a stability‐indicating RP‐HPLC approach, for the estimation of all 14 cited impurities in the solid oral dosage forms.…”