High-Performance Liquid Chromatographic Determination of Ethmozin in Plasma

Whitneyx, Charles C.; Weinstein, Stephen H.; Gaylord, Janet

doi:10.1002/jps.2600700433

Cited by 26 publications

(5 citation statements)

References 2 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In long-distance runners a radionuclide study showed normal filling rates despite an increased LV mass index [13]. Similarly, M-mode échocardiographie [11,12,14] and echo-Doppler [15,16] investigations failed to detect any LV diastolic ab normalities in exercise-induced LVH.…”

Section: Discussionmentioning

confidence: 99%

“…Quinidine was chosen as a comparative agent because of its common use in the United States as a reference antiarrhythmic agent in defining the charac teristics of new antiarrhythmic drugs. The 7-day interval between crossover of active antiarrhythmic drugs was far in excess of five drug half-lives of both moricizine and quinidine which have half-lives reported to be less than 6h [5,6,16]. A 'physiologic washout' of each antiar rhythmic drug was assured by requiring a reappearance of at least 50% of the baseline ventricular arrhythmia frequency during the second placebo period.…”

Section: Methodsmentioning

confidence: 99%

“…However, only few re ports have examined LV diastolic function in these sub jects [11][12][13][14][15][16].…”

mentioning

confidence: 99%

See 2 more Smart Citations

Left Ventricular Structure and Function in Exercise-Induced Eccentric Hypertrophy

Cassisa¹,

DiGirolamo²,

Masia³

et al. 1988

Am J Noninvas Cardiol

View full text Add to dashboard Cite

The influence of exercise training on left ventricular (LV) geometry and function was studied by 2Dguided M-mode computerized echocardiography in 14 athletes who underwent a predominantly endurance training program. Twenty age-matched untrained subjects served as controls. After a rigorous 28-week training, LV mass was increased (159 ± 27 g/m^2, p < 0.001 vs. 95 ± 20 of controls), with normal values of relative wall thickness (Th/R) and end-systolic meridional wall stress (ESS), suggesting an adequate LV eccentric hypertrophy. Fractional shortening values and the relation between LV ESS and fractional shortening excluded alterations in systolic pump performance. Also, no impairment in LV relaxation and filling indices was observed. When restudied 8 weeks after interruption of exercise, when the reconditioning had just begun, LV mass was still increased, though to a smaller degree (117 ±21 g/m^2, p < 0.001 vs. control values). Eccentric LV hypertrophy was adequate in 9 athletes, whereas 5 athletes showed low Th/R and high LV ESS values. This inadequate LV eccentric hypertrophy was probably due to an abrupt increase in workload. However, systolic and diastolic LV function analysis showed no abnormalities in any subject. We conclude that LV myocardial properties are not affected in exercise-induced LV eccentric hypertrophy. Our results provide new information on the regression of LV hypertrophy after cessation of training.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

Left Ventricular Structure and Function in Exercise-Induced Eccentric Hypertrophy

Cassisa¹,

DiGirolamo²,

Masia³

et al. 1988

Am J Noninvas Cardiol

View full text Add to dashboard Cite

show abstract

Section: Methodsmentioning

confidence: 99%

“…Plasma moricizine concentration was determined by means of paired samples using high-performance liquid chromatography with methods previously described [16]. The plasma concentration of quinidine was measured by a homogeneous enzyme immunoassay technique.…”

Section: Plasma Levelsmentioning

confidence: 99%

Comparative Efficacy of Moricizine and Quinidine for Benign and Potentially Lethal Ventricular Arrhythmias

Kennedy¹,

DeMaria²,

Sprague³

et al. 1988

Am J Noninvas Cardiol

View full text Add to dashboard Cite

The relative antiarrhythmic efficacy of moricizine and quinidine in suppressing ventricular arrhythmias in patients with benign or potentially lethal ventricular arrhythmias was examined in a placebo-controlled, doubleblind longitudinal crossover study during a 49-day protocol. Although both drugs significantly reduced total ventricular ectopic beats relative to placebo, moricizine was modestly superior to quinidine in total ventricular ectopic beat depression and also manifested a low incidence of adverse side effects. Using 75% ventricular ectopic beat reduction as the criteria for efficacy, moricizine was effective in 75% of all patients compared with an effectiveness of 60% of patients during quinidine therapy (p < 0.05). Mean trough plasma levels of moricizine and quinidine were unrelated to antiarrhythmic efficacy. Moricizine had no effect on the QT interval whereas quinidine prolonged it significantly. Importantly, while quinidine produced adverse side effects in 63% (17/27) of patients and resulted in early discontinuation of the protocol in 41 % (11/27) of patients, moricizine was well tolerated with only 25% (7/28) of patients having complaints and 14% (4/28) withdrawing early.

show abstract

The effect of hepatic disease on the disposition of moricizine in humans

Pieniaszek

Davidson

McEntegart

et al. 1994

Biopharm & Drug Disp

View full text Add to dashboard Cite

The pharmacokinetics of moricizine and two of its metabolites, moricizine sulfoxide and phenothiazine-2-carbamic acid ethyl ester sulfoxide, were studied in healthy control subjects and in patients with chronic liver disease (cirrhosis). Moricizine disposition was significantly altered by hepatic cirrhosis. Compared to healthy subjects, the hepatic disease patients had an increased Cmax (59%), an increased t1/2 (141%), and a reduced plasma clearance (71%). Additionally, small but statistically significant increases were observed for tmax and the fraction of moricizine not bound to plasma proteins in patients with hepatic disease. The elimination of both moricizine metabolites was also altered by hepatic dysfunction as indicated by significantly prolonged terminal half-lives. Furthermore, there was a reduction in the conversion of moricizine to moricizine sulfoxide. Both hepatic blood flow and hepatic metabolizing capacity were assessed in all subjects and patients by administration of indocyanine green and antipyrine, respectively. Indocyanine green and antipyrine plasma clearances were decreased by 38 and 51%, respectively, indicating that both functions were diminished by hepatic cirrhosis. We conclude that the moricizine dose required for arrhythmia patients with hepatic disease should be lower, and perhaps, the dosing frequency should be less than in patients with normal liver function.

show abstract

High-Performance Liquid Chromatographic Determination of Ethmozin in Plasma

Cited by 26 publications

References 2 publications

Left Ventricular Structure and Function in Exercise-Induced Eccentric Hypertrophy

Left Ventricular Structure and Function in Exercise-Induced Eccentric Hypertrophy

Comparative Efficacy of Moricizine and Quinidine for Benign and Potentially Lethal Ventricular Arrhythmias

The effect of hepatic disease on the disposition of moricizine in humans

Contact Info

Product

Resources

About