High-performance liquid chromatographic determination of propylthiouracil in human urine by post-column iodine–azide reaction

Zakrzewski, Robert

doi:10.1016/j.jpba.2008.04.031

Cited by 7 publications

(1 citation statement)

References 23 publications

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“…5 It may cause some side effects such as, skin rash, itching, abnormal hair loss, upset stomach, decrease in white blood cells, etc. 6,7 In vitro experiments have shown that myeloperoxidase of activated neutrophils can oxidize PTU to the reactive intermediate propyluracil 2-sulfonate (PTU-SO 3 − ), and it has been proposed that PTU-SO 3 − might be responsible for the drug-associated side effects. 8 The interaction between heterocyclic thiols (such as PTU and methimazole) and iodine has been the subject of some researches.…”

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confidence: 99%

A Kinetic Study on Electrooxidation of Propyl-Thiouracil: An Anti-Hyperthyroid Drug by Potassium Iodide

Jalali

Riahi

Nematollahi

2013

J. Electrochem. Soc.

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The kinetics of the redox reaction between anti-hyperthyroid drug, propylthiouracil (PTU), and iodine was studied by cyclic voltammetry. Iodide is the mediator in the electrocatalytic oxidation of PTU at the surface of a platinum electrode. The second order rate constant (k obs ) increased with pH in a pH range of 2 to 6. The reaction rate was also dependent on the concentration ratio of PTU to iodide. A simulation software was used to interpret the observations and to calculate k obs at different pHs.

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confidence: 99%