High-performance liquid chromatography analysis of anti-inflammatory pharmaceuticals with ultraviolet and electrospray-mass spectrometry detection in suspected counterfeit homeopathic medicinal products

Panusa, Alessia; Multari, Giuseppina; Incarnato, Giampaolo; Gagliardi, Luigi

doi:10.1016/j.jpba.2006.10.012

Cited by 77 publications

(40 citation statements)

References 54 publications

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“…Several other consequences towards the public health can be noticed such as adverse reactions, increase of morbidity and of mortality as well as loss of public confidence and waste of scarce resources, etc. [8]. Poor quality medicines can be classified into three main categories: Counterfeit, substandard and degraded medicines [9].…”

Section: Introductionmentioning

confidence: 99%

Application of Total Error Strategy in Validation of Affordable and Accessible UV-Visible Spectrophotometric Methods for Quality Control of Poor Medicines

Mbinze

Mpasi

Maghe

et al. 2015

AJAC

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In the framework of fighting against the poor quality medicines sold in developing countries using classical analytical methods easily accessible in those countries, four UV-Visible spectrophotometric methods for one antimalarial (quinine) and two antibiotics (amoxicillin and metronidazole) have been developed and validated according to the total error strategy using the accuracy profiles as a decision tool. The dosing range was 2 -10 µg/mL (for quinine sulfate in tablet), 4 -12 µg/mL (for quinine bichlorhydrate in oral drop-metronidazole benzaote in oral suspension) and 15 -35 µg/mL (for amoxicillin trihydrate in capsule). The validated methods were then applied in determining the content of some analogous medicines sold in the Democratic Republic of Congo. Thus, the proposed UV-Visible spectrophotometric methods are simple and suitable to quantify quinine, amoxicillin and metronidazole in different pharmaceutical forms.

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Section: Introductionmentioning

confidence: 99%

Application of Total Error Strategy in Validation of Affordable and Accessible UV-Visible Spectrophotometric Methods for Quality Control of Poor Medicines

Mbinze

Mpasi

Maghe

et al. 2015

AJAC

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“…The various analytical methods have been proposed for the determination of EDTA (5-9), sorbic acid (10)(11)(12)(13)(14), and diclofenac sodium (15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27)(28)(29)(30)(31). To the best of our knowledge, this study is the first report describing simultaneous determination of EDTA, sorbic acid, and diclofenac sodium in pharmaceutical preparations.…”

Section: Introductionmentioning

confidence: 99%

Simultaneous Determination of EDTA, Sorbic Acid, and Diclofenac Sodium in Pharmaceutical Preparations Using High-Performance Liquid Chromatography

2013

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Abstract. A simple high-performance liquid chromatographic method for simultaneous determination of ethylenediaminetetraacetic acid (EDTA), sorbic acid, and diclofenac sodium was developed and validated. Separation was achieved on a C 18 column (10 cm×4.6 mm) using gradient elution. The mobile phase consisted of acetonitrile-ammonium dihydrogen phosphate buffer solution (0.01 M, pH02.5, containing 0.8% tetra-n-butyl ammonium hydroxide). The detector wavelength was set at 254 nm. Under these conditions, separation of three compounds was achieved in less than 10 min. The effect of two metal salts and metal concentration on peak area of EDTA was investigated. The pH effect on retention of EDTA and sorbic acid was studied. The method showed linearity for EDTA, sorbic acid, and diclofenac in the ranges of 2.5-100.0, 5.0-200.0, and 20.0-120.0 μg/mL, respectively. The within-and between-day relative standard deviations ranged from 0.52 to 1.94%, 0.50 to 1.34%, and 0.78 to 1.67% for EDTA, sorbic acid, and diclofenac, respectively. The recovery of EDTA, sorbic acid, and diclofenac from pharmaceutical preparation ranged from 96.0-102.0%, 99.7-101.5%, to 97.0-102.5%, respectively. To the best of our knowledge, this is the first report about simultaneous determination of EDTA, sorbic acid, and diclofenac.

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“…Furthermore, it is also very important to precisely quantify these NSAIDs in pharmaceutical formulations for quality control. 1 Until now, a variety of chromatographic methods have been proposed for the determination of NSAIDs in pharmaceutical formulations and biological fluids, by gas chromatography, 2-4 spectrofluorometry, 5 high performance liquid chromatography [6][7][8][9][10][11][12][13][14][15][16][17] and capillary electrophoresis. 18 Generally, it is impossible that one patient would be prescribed for more than one kind of NSAIDs at the same time; however simultaneous determination of these drugs is useful in pharmaceutical routine analysis and biological samples.…”

Section: Introductionmentioning

confidence: 99%

Simultaneous determination of non-steroidal anti-inflammatory drugs in pharmaceutical formulations and human serum by reversed phase high performance liquid chromatography

Nawaz¹

2012

Quím. Nova

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Recebido em 8/7/11; aceito em 29/11/11; publicado na web em 23/1/12 A rapid and sensitive method using high performance liquid chromatography has been developed and validated for the simultaneous determination of non-steroidal anti-inflammatory drugs (NSAIDs) in pharmaceutical formulations and human serum. Six NSAIDs including: naproxen sodium, diclofenac sodium, meloxicam, flurbiprofen, tiaprofenic and mefenamic acid were analyzed simultaneously in presence of ibuprofen as internal standard on Mediterranea C 18 (5 µm, 250 x 0.46 mm) column. Mobile phase comprised of methanol: acetonitrile: H 2 O (60:20:20, v/v; pH 3.35) and pumped at a flow rate of 1 mL min -1 using 265 nm UV detection. The method was linear over a concentration range of 0.25-50 μg mL -1 (r 2 = 0.9999).

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High-performance liquid chromatography analysis of anti-inflammatory pharmaceuticals with ultraviolet and electrospray-mass spectrometry detection in suspected counterfeit homeopathic medicinal products

Cited by 77 publications

References 54 publications

Application of Total Error Strategy in Validation of Affordable and Accessible UV-Visible Spectrophotometric Methods for Quality Control of Poor Medicines

Application of Total Error Strategy in Validation of Affordable and Accessible UV-Visible Spectrophotometric Methods for Quality Control of Poor Medicines

Simultaneous Determination of EDTA, Sorbic Acid, and Diclofenac Sodium in Pharmaceutical Preparations Using High-Performance Liquid Chromatography

Simultaneous determination of non-steroidal anti-inflammatory drugs in pharmaceutical formulations and human serum by reversed phase high performance liquid chromatography

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