High-Performance Liquid Chromatography–Mass Spectrometry Study of the Effect of Accelerated Electrons on the Structure of Bovine Serum Albumin

Brown, A. V.; Bliznyuk, U. A.; Borshchegovskaya, P. Yu.; Ipatova, V. S.; Khmelevsky, O. Yu.; Chernyaev, A. P.; Ananyeva, I. A.; Rodin, I. A.

doi:10.1134/s002016852470002x

Inorg Mater

2024

DOI: 10.1134/s002016852470002x

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High-Performance Liquid Chromatography–Mass Spectrometry Study of the Effect of Accelerated Electrons on the Structure of Bovine Serum Albumin

A. V. Brown,

U. A. Bliznyuk,

P. Yu. Borshchegovskaya

et al.

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2024

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Cited by 1 publication

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Optimization Function for Determining Optimal Dose Range for Beef and Seed Potato Irradiation

Kozlova,

Bliznyuk,

Chernyaev

et al. 2024

Foods

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The objective of this study is to develop a universally applicable approach for establishing the optimal dose range for the irradiation of plant and animal products. The approach involves the use of the optimization function for establishing the optimal irradiation dose range for each category of plant and animal product to maximize the suppression of targeted pathogens while preserving the surrounding molecules and biological structures. The proposed function implies that pathogens found in the product can be efficiently suppressed provided that irradiation is performed with the following criteria in mind: a high irradiation dose uniformity, a high probability of irradiation hitting pathogens and controlled heterogeneity of radiobiological sensitivity of pathogens. This study compares the optimal dose ranges for animal and plant products using beef tenderloin and seed potato tubers as examples. In a series of experiments, our team traced the dose dependencies of myoglobin oxidation in beef and the amount of potential damage to albumin’s native structure. The behavior patterns of myoglobin derivatives and the amount of potential damage to albumin found in this study determined the optimal dose range, which appeared to be wider for beef irradiation compared to that for seed potato tubers, as they do not require uniform irradiation of the entire volume since targeted phytopathogens are predominantly found within the surface layers of the tubers. The use of proprietary methods involving spectrophotometry and high-performance liquid chromatography–mass spectrometry provides a novel perspective on the quantitative assessment of the myoglobin oxidation level and the potential damage to albumin’s native structure.

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Optimization Function for Determining Optimal Dose Range for Beef and Seed Potato Irradiation

Kozlova,

Bliznyuk,

Chernyaev

et al. 2024

Foods

View full text Add to dashboard Cite

show abstract

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High-Performance Liquid Chromatography–Mass Spectrometry Study of the Effect of Accelerated Electrons on the Structure of Bovine Serum Albumin

Cited by 1 publication

References 24 publications

Optimization Function for Determining Optimal Dose Range for Beef and Seed Potato Irradiation

Optimization Function for Determining Optimal Dose Range for Beef and Seed Potato Irradiation

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