High- performance liquid chromatography method applied to investigate mechanism, kinetics, isotherm, and thermodynamics of bile acid adsorption onto bile acid sequestrants

Raina, Sunny; Mungantiwar, Ashish; Halde, Supriya; Pandita, Nancy

doi:10.1080/03639045.2019.1621337

Cited by 4 publications

(2 citation statements)

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“…The good fit of the Temkin isotherm model demonstrated that adsorption was characterized by a uniform distribution of binding energies, up to a maximum binding energy [30]. There are many systems bile acid-sorbent where Temkin isotherm fitted good [40,41,[43][44][45][46]. ΔQ= (−ΔH) was positive for all the studied polymers, which indicated that the adsorption process was exothermic.…”

Section: Adsorption Isothermsmentioning

confidence: 73%

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Adsorption of Sodium Cholate on Cationic Dextran Gels: Comparison of Isotherm Binding Models

Stanciu¹,

Nichifor²,

Anca-Irina³

2021

Mater. Plast.

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Cationic dextran hydrogels having pendent 51-59 mol% N-alkyl-N,N-dimethylammonium chloride groups were synthesized and tested as adsorbents for sodium cholate. The bile acid salt sorption by these gels was evaluated by equilibrium analysis in water and 10 mM NaCl solution. The best adsorption results were obtained with amphiphilic dextran-based gels having two types of pendant ammonium chloride groups with different polarities. Experimental adsorption data for all polymers fitted good with Langmuir, Dubinin-Raduskevich and Temkin models over the entire range of ligand concentrations. The maximum experimental adsorption capacity of dextran sorbents for sodium cholate was in the range 850-1075 mg/g.

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Section: Adsorption Isothermsmentioning

confidence: 73%

“…This parameter decreases asymptotically with Ci and tends to zero at high polymer concentrations (Figure 3). Dubinin-Radushkevich model, which matched well for other bile acid salt-adsorbent systems [43,44], allows calculation the mean free energy of adsorption per molecule of adsorbate, E (kJ/mol) (Eq. 10).…”

Section: Adsorption Isothermsmentioning

confidence: 99%