High Performance of Simple Organic Phosphorescence Host–Guest Materials and their Application in Time‐Resolved Bioimaging

Wang, Yunsheng; Hong, Gao; Yang, Jie; Fang, Manman; Ding, Dan; Tang, Ben Zhong; Li, Zhen

doi:10.1002/adma.202007811

Cited by 324 publications

(282 citation statements)

References 43 publications

(79 reference statements)

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“…This result might be attributed to the interaction between ferric ions with outer vacant orbitals and O/N heteroatoms with lone pair electrons in DMAPy/BPO NPs. [51] Furthermore, the DMAPy/BPO NPs were found to exhibit different phosphorescence quench behaviors in different tissue homogenates and blood (Fig. 5i).…”

Section: Resultsmentioning

confidence: 98%

“…[1][2][3][4][5][6][7][8][9][10] Therefore, constructing organic RTP materials would bene t tissue imaging, tumor diagnosis, and drug tracking. [10][11][12][13][14][15] To date, most phosphorescent materials have poor biological tissue permeability because the wavelengths of their emission spectra are short (less than 580 nm). [16][17][18][19][20][21][22][23][24][25][26][27] This only means phosphors provide good imaging in shallow regions of an organism.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

One-axis Two-wing Guest-Host Strategy for Constructing Ultralong-lifetime Near-infrared Organic Phosphorescence Materials for Bioimaging

Xiao¹,

Hong²,

Lei³

et al. 2021

Preprint

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Organic near-infrared room temperature phosphorescence (RTP) materials have unparalleled advantages in bioimaging due to their excellent penetrability. However, limited by the energy gap law, organic matters with long wavelengths (> 700 nm) and long lifetimes (> 100 ms) have not been reported so far. In this work, we have obtained organic RTP materials with long wavelengths (657–732 nm) and long lifetimes (102–324 ms) for the first time through the one-axis two-wing guest-host strategy. The one axis refers to that the guest molecule has sufficient conjugation to reduce the lowest triplet energy level and the two wings refer to that the host assists the guest in exciton transfer and inhibits the non-radiative transition of guest excitons. These materials exhibit good tissue penetration in bioimaging. Thanks to the characteristic of long lifetime and long wavelength emissive RTP materials, the tumor imaging in living mice with a signal to background ratio value as high as 43 is successfully realized. This work provides a practical solution for the construction of organic RTP materials with both long wavelengths and long lifetimes.

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Section: Resultsmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

One-axis Two-wing Guest-Host Strategy for Constructing Ultralong-lifetime Near-infrared Organic Phosphorescence Materials for Bioimaging

Xiao¹,

Hong²,

Lei³

et al. 2021

Preprint

Self Cite

View full text Add to dashboard Cite

show abstract

“…Organic RTP and long afterglow materials are expected to be widely used in optoelectronic and biochemical fields due to their long life luminescence, diversified design, and convenient preparation. [ 52,99,113–125 ] The above four hybrid RTP materials with micro/nanostructures have their own advantages and different application potentials. Because of relatively high RTP efficiency and tunable properties, OIHMs and MOFs can be used in advanced anticounterfeiting, information encryption, and optical devices.…”

Section: Discussionmentioning

confidence: 99%

Tuning Organic Room‐Temperature Phosphorescence through the Confinement Effect of Inorganic Micro/Nanostructures

2021

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Organic room‐temperature phosphorescence (RTP), especially ultralong organic RTP (UOP), has great application potential in emerging fields, such as flexible intelligent information encryption, optical anticounterfeiting, and biological imaging. Therefore, the studies on organic RTP and UOP have attracted extensive attention in recent years. Various strategies, such as crystallization, host–guest interactions, spatial confinement, and introducing weak forces of heteroatoms, have been used to improve phosphorescence quantum yield and lifetime. Among them, the confinement effect of inorganic micro/nanostructures can effectively promote highly stable and tunable organic RTP and UOP. Both the efficiency and lifetime of RTP for organic phosphors within inorganic micro/nanostructures can be improved by the confinement of inorganic frameworks, together with interactions between organic and inorganic components. Herein, the recent progress in the RTP and UOP of organic molecules assembled in micro/nanostructures of organic/inorganic hybrid materials is summarized, including low‐dimensional metal halides, metal−organic frameworks with ordered nanochannels, silica nanocomposites with micro/nanopores, and layered nanoclays. In particular, the characteristics of each hybrid structure which are beneficial for RTP are highlighted. Finally, future directions of each hybrid material are suggested to continue to expand this area of research.

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“…The former has been systematically investigated in the past few decades [3] . With excellent phosphorescence quantum yield and decent triplet lifetime, these materials have shown huge potential in bio‐imaging, [4] information encryption, [5] anti‐counterfeiting, [6] X‐ray scintillator, [7] water‐oxygen detection, [8] OLED, [9] white‐light illumination, [10] etc. However, despite tremendous efforts in eliminating non‐radiative decay pathways, promoting the generation of triplet excitons and stabilizing triplet excited states, the duration of afterglow still lags far behind the sophisticated inorganic persistent luminescent materials.…”

Section: Figurementioning

confidence: 99%

Two‐Photon Ionization Induced Stable White Organic Long Persistent Luminescence

2021

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Organic long persistent luminescence (OLPL) materials with afterglow duration in the scale of minutes or even hours are still rare. Most OLPL systems are based on exciplexes, which require complicated multi-component system in order to realize white afterglow but with slightly compromised duration and color stability. In this work, OLPLs lasting from 20 to 40 minutes are realized in a simple binary system based on two-photon ionization mechanism, which can simultaneously harvest excitons from both singlet and triplet excited states, making it potentially one of the most promising candidates to achieve stable white OLPL. Through modulation and optimization of dopant molecules in dibenzo- [b,d]thiophen-2-yldiphenyl phosphine oxide host, the emission profiles of afterglow can be readily tuned from cyan (0.19, 0.22), cold white (0.31, 0.35), standard white (0.33, 0.33) to warm white (0.31, 0.46), with excellent color consistency.

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High Performance of Simple Organic Phosphorescence Host–Guest Materials and their Application in Time‐Resolved Bioimaging

Cited by 324 publications

References 43 publications

One-axis Two-wing Guest-Host Strategy for Constructing Ultralong-lifetime Near-infrared Organic Phosphorescence Materials for Bioimaging

One-axis Two-wing Guest-Host Strategy for Constructing Ultralong-lifetime Near-infrared Organic Phosphorescence Materials for Bioimaging

Tuning Organic Room‐Temperature Phosphorescence through the Confinement Effect of Inorganic Micro/Nanostructures

Two‐Photon Ionization Induced Stable White Organic Long Persistent Luminescence

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