High-performance, polymer-based direct cellular interfaces for electrical stimulation and recording

Kim, Seong–Min; Kim, Nara; Kim, Young-Seok; Baik, Min-Seo; Yoo, Minsu; Kim, Dong-Yoon; Lee, Won‐June; Kang, Dong‐Hee; Kim, Sohee; Lee, Kwanghee; Yoon, Myung‐Han

doi:10.1038/s41427-018-0014-9

Cited by 66 publications

(61 citation statements)

References 46 publications

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“…5a, b). Owing to the biocompatibility and conformability [45][46][47] , the PWS electrodes hardly irritate the skin, and no redness is observed even after prolonged use of 16 h (Fig. 5b).…”

Section: Resultsmentioning

confidence: 98%

Fully organic compliant dry electrodes self-adhesive to skin for long-term motion-robust epidermal biopotential monitoring

et al. 2020

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Wearable dry electrodes are needed for long-term biopotential recordings but are limited by their imperfect compliance with the skin, especially during body movements and sweat secretions, resulting in high interfacial impedance and motion artifacts. Herein, we report an intrinsically conductive polymer dry electrode with excellent self-adhesiveness, stretchability, and conductivity. It shows much lower skin-contact impedance and noise in static and dynamic measurement than the current dry electrodes and standard gel electrodes, enabling to acquire high-quality electrocardiogram (ECG), electromyogram (EMG) and electroencephalogram (EEG) signals in various conditions such as dry and wet skin and during body movement. Hence, this dry electrode can be used for long-term healthcare monitoring in complex daily conditions. We further investigated the capabilities of this electrode in a clinical setting and realized its ability to detect the arrhythmia features of atrial fibrillation accurately, and quantify muscle activity during deep tendon reflex testing and contraction against resistance.

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“…5a, b). Owing to the biocompatibility and conformability [45][46][47] , the PWS electrodes hardly irritate the skin, and no redness is observed even after prolonged use of 16 h (Fig. 5b).…”

Section: Resultsmentioning

confidence: 98%

Fully organic compliant dry electrodes self-adhesive to skin for long-term motion-robust epidermal biopotential monitoring

et al. 2020

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“…For instance, PEDOT nanofibrils prepared from a solvent-assisted crystallization method showed higher capacitance values due to the removal of excess PSS, giving long-term electrical stability that was attributed to marginal swelling, and thus, is a promising material for neural recordings. [72,73] Here, we should clarify the distinction between the OECT operation regimes based on the intrinsic conductivity of the polymer used in the channel. PEDOT:PSS and similar conducting polymer-based OECTs operate in the depletion mode.…”

Section: Detection Of Electrophysiological Signals With Polymeric MIXmentioning

confidence: 99%

Organic Bioelectronics: From Functional Materials to Next‐Generation Devices and Power Sources

2020

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Conjugated polymers (CPs) possess a unique set of features setting them apart from other materials. These properties make them ideal when interfacing the biological world electronically. Their mixed electronic and ionic conductivity can be used to detect weak biological signals, deliver charged bioactive molecules, and mechanically or electrically stimulate tissues. CPs can be functionalized with various (bio)chemical moieties and blend with other functional materials, with the aim of modulating biological responses or endow specificity toward analytes of interest. They can absorb photons and generate electronic charges that are then used to stimulate cells or produce fuels. These polymers also have catalytic properties allowing them to harvest ambient energy and, along with their high capacitances, are promising materials for next‐generation power sources integrated with bioelectronic devices. In this perspective, an overview of the key properties of CPs and examination of operational mechanism of electronic devices that leverage these properties for specific applications in bioelectronics is provided. In addition to discussing the chemical structure–functionality relationships of CPs applied at the biological interface, the development of new chemistries and form factors that would bring forth next‐generation sensors, actuators, and their power sources, and, hence, advances in the field of organic bioelectronics is described.

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“…[ 163 ] Similarly, the beating behavior of cardiomyocyte cultures has been electrically synchronized on electrospun polyaniline/poly(lactic‐ co ‐glycolic acid) fibers, [ 166 ] and modulated on a crystalline PEDOT:PSS substrate. [ 347 ]…”

Section: In Vitro Applicationsmentioning

confidence: 99%

Organic Bioelectronics: Using Highly Conjugated Polymers to Interface with Biomolecules, Cells, and Tissues in the Human Body

Higgins

Fiego

Patrick

et al. 2020

Adv Materials Technologies

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Conjugated polymers exhibit interesting material and optoelectronic properties that make them well‐suited to the development of biointerfaces. Their biologically relevant mechanical characteristics, ability to be chemically modified, and mixed electronic and ionic charge transport are captured within the diverse field of organic bioelectronics. Conjugated polymers are used in a wide range of device architectures, and cell and tissue scaffolds. These devices enable biosensing of many biomolecules, such as metabolites, nucleic acids, and more. Devices can be used to both stimulate and sense the behavior of cells and tissues. Similarly, tissue interfaces permit interaction with complex organs, aiding both fundamental biological understanding and providing new opportunities for stimulating regenerative behaviors and bioelectronic based therapeutics. Applications of these materials are broad, and much continues to be uncovered about their fundamental properties. This report covers the current understanding of the fundamentals of conjugated polymer biointerfaces and their interactions with biomolecules, cells, and tissues in the human body. An overview of current materials and devices is presented, along with highlighted major in vivo and in vitro applications. Finally, open research questions and opportunities are discussed.

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High-performance, polymer-based direct cellular interfaces for electrical stimulation and recording

Cited by 66 publications

References 46 publications

Fully organic compliant dry electrodes self-adhesive to skin for long-term motion-robust epidermal biopotential monitoring

Fully organic compliant dry electrodes self-adhesive to skin for long-term motion-robust epidermal biopotential monitoring

Organic Bioelectronics: From Functional Materials to Next‐Generation Devices and Power Sources

Organic Bioelectronics: Using Highly Conjugated Polymers to Interface with Biomolecules, Cells, and Tissues in the Human Body

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