High-Performance Polymers and Their Potential Application as Medical and Oral Implant Materials

Wiesli, Matthias Guido; Özcan, Mutlu

doi:10.1097/id.0000000000000285

Cited by 62 publications

(91 citation statements)

References 45 publications

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“…The results are confirmed by the observation that white blood cell total did not significantly change during the study, as well as compared to pre-implantation and compared to non-grafted mice. Other studies have also shown that titanium alloy (Granchi et al, 2008;Williams, 2001;Xu et al, 2013) and polymer (Dahmen et al, 1997;Wiesli and Özcan, 2015) are non-immunogenic materials.…”

Section: Dna Damage Evaluation By Comet Assaymentioning

confidence: 99%

In vitro and in vivo biocompatibility of Ti-6Al-4V titanium alloy and UHMWPE polymer for total hip replacement

Truong

Dang

et al. 2016

Biomed Res Ther

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Abstract-Introductions:Joint replacements have considerably improved the quality of life of patients with damaged joints. Over the past 30 years, there has been much effort and investigations in ways to repair damages in joints, including knee and hip joints. Materials for joint production have also been developed. Many improvements have been made in the joint replacement materials to increase their biocompatibility and longevity. This study is aimed at evaluating the in vitro and in vivo biocompatibility of Ti-6Al-4V titanium alloy and UHMWPE polymer used in total hip replacements. Methods: Ti-6Al-4V titanium alloy and UHMWPE polymer were carefully washed with sterile distilled water then autoclaved. The materials were used directly or indirectly to evaluate pyrogens, endotoxins, animal cell cytotoxicity, gene mutation, animal cell transformation, DNA synthesis, immunogenicity, histology reactions, and immune response. All assays were performed according to ISO10993 guidelines. Results: The results showed that Ti6Al-4V titanium alloy and Chirulen 1020 UHMWPE polymer satisfied all criteria for implantable materials.

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Section: Dna Damage Evaluation By Comet Assaymentioning

confidence: 99%

In vitro and in vivo biocompatibility of Ti-6Al-4V titanium alloy and UHMWPE polymer for total hip replacement

Truong

Dang

et al. 2016

Biomed Res Ther

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“…Conventional removable partial denture (RPD) frameworks are often fabricated from cobalt chromium (Co‐Cr), which has many drawbacks, such as allergic reactions, esthetic issues with the metal display, oral galvanism, and biofilm plaque formation. An alternative treatment option for patients having allergic reactions to Co‐Cr alloys is a metal‐free RPD . A polymer‐based framework consists of a modified poly(etheretherketone) (PEEK) polymer, bio high‐performance polymer (BioHPP) framework combined with acrylic resin denture teeth, and a conventional acrylic resin denture base.…”

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confidence: 99%

Virtual Evaluation of the Accuracy of Fit and Trueness in Maxillary Poly(etheretherketone) Removable Partial Denture Frameworks Fabricated by Direct and Indirect CAD/CAM Techniques

Negm

Aboutaleb

Alam-Eldein

2019

Journal of Prosthodontics

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Purpose To compare the accuracy of fit and trueness of maxillary poly(etheretherketone) (PEEK) removable partial denture (RPD) frameworks fabricated by direct and indirect computer‐aided design/computer‐aided manufacturing (CAD/CAM) techniques. Materials and Methods A definitive maxillary class I master epoxy model was duplicated to create a stone cast. The cast was scanned, and an RPD was designed. Standard tessellation language (STL) data were used to fabricate 20 identical RPD frameworks using two CAD/CAM techniques: direct milling of PEEK and indirect additive manufacturing (resin printing combined with PEEK thermopressing using the lost‐wax technique). All the frameworks for each technique (n = 10) and the reference cast were scanned. To assess the accuracy of fit, a color map was constructed using metrology software, and the misfit (distance between each framework and the reference cast) was measured at 25 standardized points. To assess the overall trueness, each framework STL file was superimposed over the original design's STL file, and the average deviation was recorded in microns. Data were statistically analyzed using t‐test. Results Color mapping showed distinct pressure areas in the anterior and posterior straps of the major connector in the indirect technique, while a more uniform distribution of the color map was observed in the direct technique. A significant difference was found between the two techniques regarding the overall accuracy of fit. Compared with the indirect technique, the milled frameworks showed significantly better overall trueness (p < 0.001). Conclusions Although a significant difference in the overall fit accuracy was noted between both techniques, the fit was an acceptable clinical fit. The fabrication method affects the fit in the anterior and posterior strap areas. The frameworks of the direct technique revealed better overall trueness values compared with the indirect technique.

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“…PEEK imparts its stiffness from aromatic benzene rings and its ability to rotate in an axial direction thanks to ether oxygen bonds. This material can be sterilized and irradiated due to its stability at temperatures above 300°C . PEEK and PEEK modified products are the most widely used high‐impact polymers in medical appliances and have been used in head, spine implant, and orthopedic surgeries with notable success .…”

Section: Definitive Abutments That Can Be Used With Titanium Fixturesmentioning

confidence: 99%

“…This material can be sterilized and irradiated due to its stability at temperatures above 300°C . PEEK and PEEK modified products are the most widely used high‐impact polymers in medical appliances and have been used in head, spine implant, and orthopedic surgeries with notable success . With stiffness double that of lithium disilicate and similar to cortical bone, this material can alleviate excessive stress being directed on implants and provide lesser stress shielding, a characteristic also noted in trauma and orthopedic reconstructions.…”

Section: Definitive Abutments That Can Be Used With Titanium Fixturesmentioning

confidence: 99%

“…PEEK can be reinforced by carbon or glass fibers and can be nanomodified by bioactive nanoparticles . PEEK medical implants are radiolucent with the obvious advantage of not interfering with postoperative and prognostic radiographic imaging modalities, including CBCTs, allowing for osseointegration assays .…”

Section: Definitive Abutments That Can Be Used With Titanium Fixturesmentioning

confidence: 99%

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Use of High Performance Polymers as Dental Implant Abutments and Frameworks: A Case Series Report

Alrababah

Hamadneh

Alsalem

et al. 2017

Journal of Prosthodontics

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Dental implant abutments can be made of different materials including titanium, gold, zirconia, alumina, and polymeric materials. Polyetheretherketone (PEEK) is a high performance thermoplastic polymer that can be used as a dental implant abutment material. It has an elastic modulus comparable to bone and can reduce stress shielding. PEEK is a radiolucent material that can allow better radiographic imaging of peri-implant tissues and can be veneered with composite materials or bonded to ceramics. PEEK is widely used in orthopedic and spinal surgeries, and it possesses mechanical and biological characteristics that encourage its use as dental implant abutments. This article will review the use of PEEK in dentistry and in particular as a dental implant abutment and over implant framework. Clinical reports will be presented to suggest some uses of PEEK materials in implant dentistry.

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High-Performance Polymers and Their Potential Application as Medical and Oral Implant Materials

Abstract: The HPPs (ie, PEEK) may carry some potential to be an alternative material for titanium as medical and dental implants. Yet, clinical and animal studies are limited in the field of implantology with such materials.

Cited by 62 publications

References 45 publications

In vitro and in vivo biocompatibility of Ti-6Al-4V titanium alloy and UHMWPE polymer for total hip replacement

In vitro and in vivo biocompatibility of Ti-6Al-4V titanium alloy and UHMWPE polymer for total hip replacement

Virtual Evaluation of the Accuracy of Fit and Trueness in Maxillary Poly(etheretherketone) Removable Partial Denture Frameworks Fabricated by Direct and Indirect CAD/CAM Techniques

Use of High Performance Polymers as Dental Implant Abutments and Frameworks: A Case Series Report

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