High-performance porous PLLA-based scaffolds for bone tissue engineering: Preparation, characterization, and in vitro and in vivo evaluation

Ju, Jiajun; Peng, Xiangfang; Huang, Keqing; Li, Lengwan; Liu, Xianhu; Chitrakar, Chandani; Chang, Lingqian; Gu, Zhipeng; Kuang, Tairong

doi:10.1016/j.polymer.2019.121707

Cited by 88 publications

(63 citation statements)

References 58 publications

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“…5 A highly porous and interconnected 3D structure will not only facilitate cell adhesion, migration, and reproduction into the interior part of the scaffold, but also can support the mass transport of cell nutrients and waste. 6 In fact, it is not easy to produce such high-porosity scaffolds with specied geometric shapes and the necessary mechanical properties. Being hierarchical in pore size refers to the various scales and their effects; for example, mesoscopic pores (>50 mm) inuence tissue shape, microscopic pores (1-50 mm) inuence cell function, and nanoscopic pores (<1 mm) inuence nutrient diffusion.…”

Section: Introductionmentioning

confidence: 99%

Fabrication of fibrillated and interconnected porous poly(ε-caprolactone) vascular tissue engineering scaffolds by microcellular foaming and polymer leaching

et al. 2020

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Section: Introductionmentioning

confidence: 99%

Fabrication of fibrillated and interconnected porous poly(ε-caprolactone) vascular tissue engineering scaffolds by microcellular foaming and polymer leaching

et al. 2020

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“…First, poly(L-lactic acid) (PLLA) has been widely used for various medical applications, such as surgical sutures, bone fixation materials, and cell culture scaffolds owing to its high biocompatibility, biodegradability, modulus, mechanical hardness, and transparency [19][20][21][22]. PLLA is a plastic with the melting temperature of approximately 180 • C, and these products are injection or extrusion molded.…”

Section: Introductionmentioning

confidence: 99%

Development of Advanced Biodevices Using Quantum Beam Microfabrication Technology

Oyama

Kimura

Nagasawa

et al. 2020

QuBS

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Biodevices with engineered micro- and nanostructures are strongly needed for advancements in medical technology such as regenerative medicine, drug discovery, diagnostic reagents, and drug delivery to secure high quality of life. The authors produced functional biocompatible plastics and hydrogels with physical and chemical properties and surface microscopic shapes that can be freely controlled in three dimensions during the production process using the superior properties of quantum beams. Nanostructures on a biocompatible poly(L-lactic acid) surface were fabricated using a focused ion beam. Soft hydrogels based on polysaccharides were micro-fabricated using a focused proton beam. Gelatin hydrogels were fabricated using γ-rays and electron beam, and their microstructures and stiffnesses were controlled for biological applications. HeLa cells proliferated three-dimensionally on the radiation-crosslinked gelatin hydrogels and, furthermore, their shapes can be controlled by the micro-fabricated surface of the hydrogel. Long-lasting hydrophilic concave structures were fabricated on the surface of silicone by radiation-induced crosslinking and oxidation. The demonstrated advanced biodevices have potential applications in three-dimensional cell culture, gene expression control, stem cell differentiation induction/suppression, cell aggregation into arbitrary shapes, tissue culture, and individual diagnosis in the medical field.

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“…Nonetheless, the important advantages of synthetic polymers when compared to the natural ones, are their favorable mechanical properties. Therefore, they are often the first-choice materials in many biomedical applications [28][29][30][31].…”

Section: Introductionmentioning

confidence: 99%

Polylactide/Hydroxyapatite Nonwovens Incorporated into Chitosan/Graphene Materials Hydrogels to Form Novel Hierarchical Scaffolds

Kosowska

Domalik-Pyzik

Krok-Borkowicz

et al. 2020

IJMS

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In this study, hierarchical, cylindrical scaffolds based on polylactide (PLA) microfibers incorporated into chitosan (CS) hydrogel were prepared for potential use in bone tissue engineering. PLA nonwovens modified with hydroxyapatite particles (HAp) were obtained using the electrospinning method. Then, three-dimensional scaffolds were created by rolling up the nonwovens and immersing them in CS-based solutions with graphene oxide (GO) or reduced graphene oxide (rGO) dispersed in the polymer matrix. Hydrogels were cross-linked using a novel freezing-thawing-gelling method. A broad spectrum of research methods was applied in order to thoroughly characterize both the nanofillers and the composite systems: scanning electron microscopy, X-ray photoelectron spectroscopy, X-ray diffractometry, attenuated total reflection Fourier transform infrared spectroscopy, rheological and mechanical testing, as well as the assessment of chemical stability, bioactivity and cytocompatibility.

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High-performance porous PLLA-based scaffolds for bone tissue engineering: Preparation, characterization, and in vitro and in vivo evaluation

Cited by 88 publications

References 58 publications

Fabrication of fibrillated and interconnected porous poly(ε-caprolactone) vascular tissue engineering scaffolds by microcellular foaming and polymer leaching

Fabrication of fibrillated and interconnected porous poly(ε-caprolactone) vascular tissue engineering scaffolds by microcellular foaming and polymer leaching

Development of Advanced Biodevices Using Quantum Beam Microfabrication Technology

Polylactide/Hydroxyapatite Nonwovens Incorporated into Chitosan/Graphene Materials Hydrogels to Form Novel Hierarchical Scaffolds

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