High performance shape memory foams with isocyanate-modified hydroxyapatite nanoparticles for minimally invasive bone regeneration

Xie, Ruiqi; Hu, Jinlian; Ng, Frankie; Tan, Lin; Qin, Tingwu; Zhang, Mingqiu; Guo, Xia

doi:10.1016/j.ceramint.2016.11.216

Cited by 37 publications

(11 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…While organic biomaterials including gelatin, [44,45] chitosan, [46] hyaluronic acid, collagen, [47] and alginate as well as synthetic polymers such as poly(lactic acid) (PLA), poly(glycolic acid)(PGA), poly(propylene fumarate) (PPF), and poly(caprolactone) (PCL) have been extensively studied, successful incorporation of biomimetic levels of ceramic has remained elusive, with significant instances of phase separation, brittleness and mechanical failure, and poor in vivo integration and regeneration. [24,[48][49][50][51][52] Modification strategies to one or both phases, such as conjugation of ceramic binding groups to polymer chains or surface modification of ceramics with lactic acid oligomers, [53] isocyanates, [54] poly(amino acids), catechols, [52,55] or silanes have resulted in enhanced physical properties; however, such processes are inherently limited due to the low reactivity of ceramic surface groups and increase both cost and complexity, motivating the search for composite systems with inherent biomimetic structures. [52,56] Citrate has emerged as a critical structural component of native bone, comprising 5% by weight and covering 1/6 of the inorganic bone surface, strongly associating with both the fibrous collagen organic phase and amorphous calcium phosphate (ACP) inorganic phase during bone formation, decreasing surface binding energy between the two phases and facilitating intra-and interfibrillar mineralization.…”

Section: Intrinsically Biomimetic and Multifunctional Bplp-ser/ha Put...mentioning

confidence: 99%

Development of Biodegradable Osteopromotive Citrate‐Based Bone Putty

Tan

Gerhard

Wang

et al. 2022

Small

View full text Add to dashboard Cite

The burden of bone fractures demands development of effective biomaterial solutions, while additional acute events such as noncompressible bleeding further motivate the search for multi‐functional implants to avoid complications including osseous hemorrhage, infection, and nonunion. Bone wax has been widely used in orthopedic bleeding control due to its simplicity of use and conformation to irregular defects; however, its nondegradability results in impaired bone healing, risk of infection, and significant inflammatory responses. Herein, a class of intrinsically fluorescent, osteopromotive citrate‐based polymer/hydroxyapatite (HA) composites (BPLP‐Ser/HA) as a highly malleable press‐fit putty is designed. BPLP‐Ser/HA putty displays mechanics replicating early nonmineralized bone (initial moduli from ≈2–500 kPa), hydration induced mechanical strengthening in physiological conditions, tunable degradation rates (over 2 months), low swelling ratios (<10%), clotting and hemostatic sealing potential (resistant to blood pressure for >24 h) and significant adhesion to bone (≈350–550 kPa). Simultaneously, citrate's bioactive properties result in antimicrobial (≈100% and 55% inhibition of S. aureus and E. coli) and osteopromotive effects. Finally, BPLP‐Ser/HA putty demonstrates in vivo regeneration in a critical‐sized rat calvaria model equivalent to gold standard autograft. BPLP‐Ser/HA putty represents a simple, off‐the‐shelf solution to the combined challenges of acute wound management and subsequent bone regeneration.

show abstract

Section: Intrinsically Biomimetic and Multifunctional Bplp-ser/ha Put...mentioning

confidence: 99%

Development of Biodegradable Osteopromotive Citrate‐Based Bone Putty

Tan

Gerhard

Wang

et al. 2022

Small

View full text Add to dashboard Cite

show abstract

“…They proved that they can enhance myogenic differentiation from C2C12 myoblast cells. Xie R.et al Xie et al (2017) prepared a novel polyurethane or hydroxyapatite based SMP porous foam for the treatment of load-bearing bone defects by gas foaming. The foam can match the trabecular bone, possess the feasibility of minimally invasive delivery.…”

Section: Responsive Bioactive Materials Can Promote the Reconstructio...mentioning

confidence: 99%

Discussion on the possibility of multi-layer intelligent technologies to achieve the best recover of musculoskeletal injuries: Smart materials, variable structures, and intelligent therapeutic planning

Guo

Tian

Wang

et al. 2022

Front. Bioeng. Biotechnol.

View full text Add to dashboard Cite

Although intelligent technologies has facilitated the development of precise orthopaedic, simple internal fixation, ligament reconstruction or arthroplasty can only relieve pain of patients in short-term. To achieve the best recover of musculoskeletal injuries, three bottlenecks must be broken through, which includes scientific path planning, bioactive implants and personalized surgical channels building. As scientific surgical path can be planned and built by through AI technology, 4D printing technology can make more bioactive implants be manufactured, and variable structures can establish personalized channels precisely, it is possible to achieve satisfied and effective musculoskeletal injury recovery with the progress of multi-layer intelligent technologies (MLIT).

show abstract

“…One common approach to improving the mechanical performance of SMPs is to introduce nanofillers into the SMP matrix [20,21]. Graphene is a kind of new material, composed of sp 2 -bonded carbon atoms, which has excellent mechanical, optical, and conductive properties, as well as good biocompatibility because of its special structure [22,23].…”

Section: Introductionmentioning

confidence: 99%

Isocyanate Modified GO Shape-Memory Polyurethane Composite

Zhang

2020

Polymers

Self Cite

View full text Add to dashboard Cite

Shape-memory composites have benefits for minimally invasive surgery, but their wider applications for bone repair are hindered by conflicts between the mechanical and memory performances, especially at load-bearing locations. In this study, we fabricated a graphene oxide shape-memory polyurethane composite through the chemical combination of graphene oxide and isocyanate, in order to realize satisfactory mechanical and shape-memory effects. As desired, a modulus of ~339 MPa and a shape recovery ratio of 98% were achieved, respectively, in the composite. In addition, finite element analysis demonstrated that, after being implanted in a defective bone through a minimally invasive treatment, where the highest stress was distributed at the implant–bone interface, this composite could offer a generated force during the recovery process. Furthermore, we also discuss the origins of the improved mechanical and memory properties of the composites, which arise from increased net-points and the stable molecular structure inside. Therefore, with its superior structure and properties, we envision that this shape-memory composite can provide new insights toward the practical application of shape-memory polymers and composites in the field of bone repair.

show abstract

High performance shape memory foams with isocyanate-modified hydroxyapatite nanoparticles for minimally invasive bone regeneration

Cited by 37 publications

References 38 publications

Development of Biodegradable Osteopromotive Citrate‐Based Bone Putty

Development of Biodegradable Osteopromotive Citrate‐Based Bone Putty

Discussion on the possibility of multi-layer intelligent technologies to achieve the best recover of musculoskeletal injuries: Smart materials, variable structures, and intelligent therapeutic planning

Isocyanate Modified GO Shape-Memory Polyurethane Composite

Contact Info

Product

Resources

About