High Performance Thin-Layer Chromatography

Milojković‐Opsenica, Dušanka; Andrić, Filip

doi:10.1007/978-94-007-7735-4_4

Cited by 7 publications

(4 citation statements)

References 66 publications

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Section: Resultsmentioning

confidence: 99%

“…28,38,39 Adopting the 3R green philosophy (reuse, replace, reduce), the sustainability extent of HPTLC could be greatly promoted through either substituting hazardous solvents with eco-friendlier ones or reducing their consumption. 19,20 Consequently, our efforts were focused on excluding any reported hazardous solvents used for ALF and SOL separation, like methanol, acetonitrile, chloroform, dichloromethane and toluene, and resorting to greener ones as per the Glax-oSmithKline (GSK) solvent sustainability guide. 40 Of these solvents, n-butanol, isopropanol, ethanol, ethyl acetate and acetone were examined in various ratios for efficient separation of the studied drug mixture.…”

Section: Development and Optimization Of Hptlc Separationmentioning

confidence: 99%

“…Furthermore, HPTLC complies with the principles of green analytical chemistry through swapping hazardous solvents with more sustainable ones. 19,20 A literature survey revealed the adoption of the high-performance liquid chromatographic (HPLC) technique for detecting residual content of drugs, [21][22][23][24] but the applicability of the HPTLC technique as a greener analytical candidate for cleaning validation has not yet been reported in any published work.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

A novel smartphone HPTLC assaying platform versus traditional densitometric method for simultaneous quantification of alfuzosin and solifenacin in their dosage forms as well as monitoring content uniformity and drug residues on the manufacturing equipment

et al. 2023

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Section: Resultsmentioning

confidence: 99%

Section: Development and Optimization Of Hptlc Separationmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

A novel smartphone HPTLC assaying platform versus traditional densitometric method for simultaneous quantification of alfuzosin and solifenacin in their dosage forms as well as monitoring content uniformity and drug residues on the manufacturing equipment

et al. 2023

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“…The most commonly used measure of lipophilicity is partition coefficient, log P, which represents the ratio of equilibrium concentrations of a substance in two phases of a system consisting of 1octanol and water [14,15]. In addition to the partition coefficient, chromatographic parameters, RM 0 , m, and C0, obtained by reversed-phase thin layer chromatography (RPTLC) [16][17][18][19] are used as reliable alternative measures of lipophilicity. The contemporary design of biologically active compounds, beside lipophilicity, requires a relevant assessment of the risks of their toxic effects in the environment and the study of the conditions under which they may be manifested.…”

Section: Introductionmentioning

confidence: 99%

Study of the Biological Activity Descriptors of the Barbituric Acid Derivatives

Apostolov¹,

Vaštag²,

Matijević³

et al. 2020

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Barbituric acid derivatives have been pharmacologically significant compounds for decades. The central nervous system effects are conditioned by the presence of the pyrimidine-trione ring and the nature of the substituent in position 5. Lipophilicity as one of the key molecular descriptors of biological activity for selected barbituric acid derivatives was determined experimentally, using reversed-phase thin layer chromatography (RP TLC18 F254s), in two solvent systems. The influence of the substituent’s nature and the effects of applied organic modifiers on the chromatographic behavior of the tested derivatives were examined. For the studied derivatives the values of the partition coefficient (logP) as a standard measure of lipophilicity and effective concentration (EC50) as a measure of acute toxicity for different test organisms were calculated applying the appropriate software packages. Dependence between the chromatographic parameters as assumed measures of lipophilicity and the software-derived biological activity parameters of the studied barbituric acid derivatives were studied by linear regression analysis.

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Novel HPTLC densitometric methods for determination of tamsulosin HCl and tadalafil in their newly formulated dosage form: Comparative study and green profile assessment

Tantawy

Weshahy

Wadie

et al. 2020

Biomedical Chromatography

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A promising combination of tamsulosin HCl and tadalafil has recently been introduced for treating two prevalent and associated urological disorders: benign prostate hyperplasia and erectile dysfunction. Novel HPTLC methods were designed and validated for assaying the cited drugs in their challenging combined formulation. Separation was achieved using HPTLC silica gel 60 F254 plates as a stationary phase with a densitometric measurement at 280 nm. The proposed methods with two different chromatographic systems were successfully applied: a conventional mixture (method I) of ethyl acetate–toluene–methanol–ammonia (5:3:2:0.5, by volume) and a greener one (method II) with ethyl acetate–ethanol–ammonia (8:2:0.1, by volume). The two methods were evaluated through a comparative study in terms of selectivity, tailing factor, developing time and concentration ranges. The greenness profile for each method was then appraised with several green guides, namely GlaxoSmithKline solvent sustainability guide, Environmental, Health and Safety (EHS) tool, National Environmental Method Index (NEMI) and Eco‐scale. Moreover, method specificity and peak homogeneity were evaluated by peak purity assessment using the winCATS® software spectral correlation tool. The methods have potential for being simple, fast, economic and selective, and the greener one could be a good option for sustainable analysis of the drugs.

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High Performance Thin-Layer Chromatography

Cited by 7 publications

References 66 publications

A novel smartphone HPTLC assaying platform versus traditional densitometric method for simultaneous quantification of alfuzosin and solifenacin in their dosage forms as well as monitoring content uniformity and drug residues on the manufacturing equipment

A novel smartphone HPTLC assaying platform versus traditional densitometric method for simultaneous quantification of alfuzosin and solifenacin in their dosage forms as well as monitoring content uniformity and drug residues on the manufacturing equipment

Study of the Biological Activity Descriptors of the Barbituric Acid Derivatives

Novel HPTLC densitometric methods for determination of tamsulosin HCl and tadalafil in their newly formulated dosage form: Comparative study and green profile assessment

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