High perirenal fat thickness predicts a greater risk of recurrence in Chinese patients with unilateral nephrolithiasis

Abstract

Introduction The aim of this study was to evaluate the association between recurrence-free survival (RFS) and perirenal fat thickness (PFT) in a cohort of Chinese population with unilateral nephrolithiasis. Methods We retrospectively reviewed the medical records of 81 patients with unilateral nephrolithiasis in our center from January 2019 to June 2019. PFT measured on computed tomography (CT) scans was evaluated. Kaplan-Meier curves and log-rank tests were used to assess significant differences in RSF between high-PFT and low-PFT groups within sexes. Univariable and multivariable Cox regression analyses were used to evaluate the potential risk factors for renal stone recurrence. Results High PFT was significantly associated with high BMI and hyperlipidemia ( p = .003 and.047, respectively). The PFT of stone-bearing kidney was significantly greater than PFT of non-stone-bearing kidney (0.77 ± 0.60 cm vs. 0.67 ± 0.58 cm, p = .002) . During the follow-up periods (median 31 months), 21 (25.9%) patients experienced ipsilateral renal stone recurrence. In addition, Kaplan–Meier survival curves showed that patients with low PFT had a significant better RFS than those with high PFT ( p = .012). In the univariable Cox analyses, male sex and high PFT were significantly associated with a poor RFS ( p = .042 and .018, respectively). Moreover, both male sex and high PFT retained significance in the multivariable analyses ( p = .045 and .020, respectively). Conclusions Our findings suggested that PFT is a noninvasive and feasible parameter, which may help in the risk stratification of renal stone recurrence in the follow-up periods.

Association of novel anthropometric indices with prevalence of kidney stone disease: a population-based cross-sectional study

“…Nevertheless, investigations exploring the association between BRI and KSD in other populations remain lacking. Huang H. et al also discovered that perirenal fat thickness is a noteworthy predictive factor for the development and recurrence of KSD in a Chinese population, suggesting its potential utility in risk stratification during follow-up periods [ 29 ]. Consequently, reducing the prevalence of obesity, particularly abdominal obesity, may have a crucial role in preventing KSD.…”

Thickened Perirenal Fat Predicts Poor Renal Outcome in Patients with Immunoglobulin A Nephropathy: A Population-Based Retrospective Cohort Study

“…PRF is a specific site of visceral fat deposition and is closely associated with several diseases such as cardiovascular disease, diabetes, and renal disease [ 7 ]. PRF has a higher predictive value for CKD than total, subcutaneous, or visceral fat in patients with type 2 diabetes mellitus patients [ 8 , 18 ].…”

“…Composed of both brown adipose tissue and white adipose tissue, PRF is able to synthesize and secrete many adipokines, such as leptin, adiponectin, and so on [ 5 ]. PRF plays an essential role in various diseases such as hypertension [ 6 ], unilateral nephrolithiasis [ 7 ], renal cell carcinoma [ 8 ], metabolic syndrome, and atherosclerosis [ 9 ]. In addition, its role in various renal diseases has been previously proposed [ 10 – 12 ].…”