High Phosphorus Diet Changes Phosphorus Metabolism Regardless of PTH Action in Rats

Katsumata, Seishi; Masuyama, Ritsuko; Koshihara, Moyuru; Matsuzaki, Hiroshi; Uehara, Mariko; Suzuki, Kazuharu

doi:10.1271/bbb.68.243

Cited by 13 publications

(15 citation statements)

References 14 publications

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“…It is also known that the elevated PTH concentration from a high-P diet increased bone resorption. 5) In this study, although the high-P diet tended to elevate the serum PTH concentration, a significant increase in the urinary excretion of deoxypyridinoline by adult female rats was observed. Moreover, BMD of L5 was decreased more in adult female rats fed the high-P diet than in those fed the control diet.…”

mentioning

confidence: 47%

“…Consequently, Ca absorption is an important factor for bone mineralization during excess-P intake. Although we previously reported the effect of a high-P diet on bone metabolism in young male rats, 5) little is known about the effect of dietary P intake on bone metabolism in adult female rats. We observed sex differences in the kidney mineral concentration in rats given a highphosphorus diet in the previous study.…”

mentioning

confidence: 99%

“…We have previously reported that an increase in the biochemical marker of bone resorption, urinary Cterminal telopeptides of type I collagen excretion, was apparent in young male rats fed an excess-P diet. 5) It is possible to speculate that secondary hyperparathyroidism, which is caused by a decrease in Ca absorption, is concerned with bone loss by excess-P intake. Consequently, Ca absorption is an important factor for bone mineralization during excess-P intake.…”

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confidence: 99%

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Effects of Dietary Phosphorus Intake on Bone Mineralization and Calcium Absorption in Adult Female Rats

Koshihara

Katsumata

Uehara

et al. 2005

Bioscience, Biotechnology, and Biochemistry

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confidence: 47%

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confidence: 99%

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confidence: 99%

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Effects of Dietary Phosphorus Intake on Bone Mineralization and Calcium Absorption in Adult Female Rats

Koshihara

Katsumata

Uehara

et al. 2005

Bioscience, Biotechnology, and Biochemistry

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“…The contents of hydroxyproline (collagen marker) and osteocalcin decreases in the plasma and urine [4]. The amount of type I collagen N-telopeptides decreases, while the content of procollagen C-propeptides increases in the plasma and urine [5,[6][7][8]13]. The polypeptide chain of bone Gla protein contains 49 amino acid residues, including 3 residues of γ-carboxyglutamic acid that bind Ca 2+ .…”

Section: Resultsmentioning

confidence: 99%

“…In animals and humans PTEC is followed by changes in the content of C-and N-terminal peptide markers of type I collagen and Ca 2+ -binding noncollagen proteins in the blood and urine [4][5][6][7][8]12,13].…”

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Effect of parathyroidectomy on fluctuations in calcium transport between the blood and mineralized tissues of rats

Petrovich¹,

Volozhin²,

Kichenko³

et al. 2006

Bull Exp Biol Med

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Parathyroidectomy increases the degree of(45)Ca fluctuations between the blood and mineralized tissues (bones and teeth) in rats, which is associated with a decrease in 14C-glycine incorporation into bone proteins. Disturbances in Ca(2+)metabolism and transport during hyperparathyroidism are partly prevented by parathyroidectomy. It is mainly related to variations in the interaction of parathyroid hormone, calcitonin, 1.25(OH)2D3, and other bioactive substances, but not to initiation of mineralization with protein matrixes.

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Effect of high phosphorus diet on phosphorus metabolism in parathyroidectomized rats

et al. 2004

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To determine the parathyroid hormone (PTH) action on kidney and bone by high phosphorus (P) diet, this study investigated PTH/PTH-related peptide (PTHrP) receptor mRNA expression in 6-week-old parathyroidectomized (PTX) rats received constant amount of PTH. To maintain serum PTH levels equally to sham operated rats, PTX rats were constantly exposed to rPTH (1-34) and fed a control diet (0.3% P) and a high P diet (1.2% P) for 7 days, respectively. There were no significant differences in serum PTH (1-34) concentration in rats fed the control diet. In sham groups, serum PTH concentrations, both (1-84) and (1-34) fragments, were increased in rats fed the high P diet than in rats fed the control diet. Urinary excretions of P and C-terminal telopeptides of type I collagen were significantly increased in both PTX and sham rats by the high P diet. PTH/PTHrP receptor mRNA expression in kidney and femur was not changed in both PTX and sham rats by the high P diet. In conclusion, high P diet did not change PTH action in PTX rats and increased urinary excretion of P and bone resorption regardless of PTH action.

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High Phosphorus Diet Changes Phosphorus Metabolism Regardless of PTH Action in Rats

Cited by 13 publications

References 14 publications

Effects of Dietary Phosphorus Intake on Bone Mineralization and Calcium Absorption in Adult Female Rats

Effects of Dietary Phosphorus Intake on Bone Mineralization and Calcium Absorption in Adult Female Rats

Effect of parathyroidectomy on fluctuations in calcium transport between the blood and mineralized tissues of rats

Effect of high phosphorus diet on phosphorus metabolism in parathyroidectomized rats

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