High photothermal properties in silicon nanostructures

Ren, Ting-Ting; Wei, Mao-Qugn; Hsiao, Chin-Chiang; Chen, Bo–Yi; Li, Meiyi; Liou, Jui-Min; Ko, Fu‐Hsiang; Lai, Yung‐Cheng

doi:10.1109/am-fpd.2016.7543672

Cited by 1 publication

(1 citation statement)

References 4 publications

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“…On the other hand, the temperature of MPSi solution was more significantly increased from 23.7 • C to 45.3 • C, and the GO-wrapped FMPSi exhibited the maximal increase in temperature (up to 52.8 • C). These results indicate that silicon nanostructure with numerous mesopores exhibits high photo-induced hyperthermia due to its excellent photothermal conversion efficiency, high surface area, and low reflectivity (or antireflection) [64,65]. GO wrapping can further increase NIR absorption through the laser-induced reduction of GO [66,67].…”

Section: Photothermal Heating By Nir Irradiationmentioning

confidence: 87%

Dual Stimuli-Responsive Multifunctional Silicon Nanocarriers for Specifically Targeting Mitochondria in Human Cancer Cells

et al. 2022

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Specific targeting, selective stimuli-responsiveness, and controlled release of anticancer agents are requested for high therapeutic efficiency with a minimal adverse effect. Herein, we report the sophisticated synthesis and functionalization of fluorescent mesoporous silicon (FMPSi) nanoparticles decorated with graphene oxide (GO) nanosheets. GO-wrapped FMPSi (FMPSi@GO) was loaded with a cisplatin (Cis) anticancer agent, and Cis-loaded FMPSi@GO (FMPSi-Cis@GO) exhibited the dual stimuli (pH and NIR)-responsiveness of controlled drug release, i.e., the drug release rate was distinctly enhanced at acidic pH 5.5 than at neutral pH 7.0 and further enhanced under NIR irradiation at acidic pH condition. Notably, dequalinium-conjugated FMPSi-Cis@GO (FMPSi-Cis@GO@DQA) demonstrated an excellent specificity for mitochondrial targeting in cancer cells without noticeable toxicity to normal human cells. Our novel silicon nanocarriers demonstrated not only stimuli (pH and NIR)-responsive controlled drug release, but also selective accumulation in the mitochondria of cancer cells and destroying them.

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