High plasma level of long Pentraxin 3 is associated with insulin resistance in women with polycystic ovary syndrome

Aydoğdu, Aydoğan; Taşçı, İlker; Tapan, Serkan; Başaran, Yalçın; Aydoğan, Ümit; Meriç, Coşkun; Sönmez, Alper; Aydogdu, Sebnem; Akbulut, Halil; Taşlıpınar, Abdullah; Üçkaya, Gökhan; Azal, Ömer

doi:10.3109/09513590.2011.652719

Cited by 26 publications

(26 citation statements)

References 23 publications

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“…PTX3 is present in atherosclerotic lesions and in small-vessel vasculitis in humans [22,30]. Aydogdu et al [31] investigated the association between PTX3 levels and insulin resistance in patients with polycystic ovarian syndrome. They found increased plasma PTX3 levels in women with polycystic ovarian syndrome compared with healthy controls.…”

Section: Discussionmentioning

confidence: 99%

Is There Any Relationship between Plasma Pentraxin 3 Levels and Gestational Diabetes Mellitus?

Yıldırım¹,

Simavlı²,

Derbent³

et al. 2015

Gynecol Obstet Invest

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Background: Pentraxin 3 (PTX3) is a novel vascular inflammatory marker which increases in vascular events such as diabetes mellitus. The aim of this study was to investigate the relationship between serum PTX3 levels and gestational diabetes mellitus (GDM). Methods: This prospective observational study was comprised of 88 pregnant women with singleton pregnancies. The subjects were classified into 3 groups according to their response to a 50-gram glucose challenge test (GCT) and a 100-gram oral glucose tolerance test: control group (n = 28), impaired glucose tolerance group (n = 30), and GDM group (n = 30). Serum PTX3 levels were measured to examine the relationship between GDM and GCT values. Results: Significant differences in PTX3 levels were observed among the 3 groups in the sample (F = 7.598; p = 0.001). The mean PTX3 value was found to be significantly higher in the GDM group (3.17 ± 1.16 ng/ml) than in the control group (2.20 ± 0.83 ng/ml; p = 0.001). A significant positive correlation between PTX3 and GCT values was detected (r = 0.289; p = 0.008). Conclusion: Maternal serum PTX3 levels were found to be significantly related to high blood glucose levels. This may be an indicator of vascular pathology in GDM around the time of an oral glucose tolerance test.

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Section: Discussionmentioning

confidence: 99%

Is There Any Relationship between Plasma Pentraxin 3 Levels and Gestational Diabetes Mellitus?

Yıldırım¹,

Simavlı²,

Derbent³

et al. 2015

Gynecol Obstet Invest

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“…Recent studies have shown high PTX3 levels are associated with unstable angina [13], adverse outcomes after myocardial infarction [14] and heart failure [15], and suggested PTX3 as a prognostic marker for CVD. In the literature there is only one study investigating the PTX3 levels in PCOS and they found higher PTX3 levels in the PCOS group than control group (1.0 ± 3.6 vs. 0.8 ± 0.3, p = 0.021) [16]. Although the groups had a similar number and the diagnosis of PCOS was made with the same criteria (ESHRE/ASRM Rotterdam), in the present study we found no difference in the PCOS and control groups.…”

Section: Discussionmentioning

confidence: 99%

“…In our study, PTX3 levels were higher in women with PCOS, but these did not reach statistical significance (1.44 ± 1.62 vs. 1.16 ± 0.87, p = 0.927). Furthermore, Aydoğdu et al [16] reported that PTX3 levels were correlated positively with BMI, WHR, hs-CRP and HOMA-IR (p < 0.05 for all). Similarly in the present study we found a positive correlation between PTX3 and weight, BMI, IR, and HOMA-IR.…”

Section: Discussionmentioning

confidence: 99%

Is Pentraxin 3 a New Cardiovascular Risk Marker in Polycystic Ovary Syndrome?

Sarı

Kaygusuz

Kafalı

2014

Gynecol Obstet Invest

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Background/Aims: Polycystic ovary syndrome (PCOS) patients have an increased rate of subclinical inflammation, which plays a role in the pathogenesis of atherosclerosis. Pentraxin 3 (PTX3) is an inflammatory mediator which belongs to the same family as the well-established cardiovascular biomarker C-reactive protein (CRP). The present study was performed to investigate plasma PTX3 levels in patients with PCOS and to determine the relationship between PTX3 and other known cardiovascular risk factors. Methods: 40 patients with PCOS and 40 age- and BMI-matched healthy controls were included in the study. The groups were divided into subgroups according to BMI. Insulin resistance indexes, lipid profile, CRP and PTX3 levels were analyzed. Results: There was no difference for insulin resistance indexes and lipid profile between the PCOS and control groups. CRP levels were significantly higher in obese PCOS and control subjects than in lean subjects, whereas no difference in PTX3 concentrations was observed between subgroups. Conclusion: PTX3 and CRP levels were similar in the PCOS group compared with the non-PCOS control group.

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“…To the best of our knowledge, only one recent study, carried out by Aydogdu et al (15), previously assessed PTX3 levels in PCOS women. Unlike in our findings, in this study PTX3 concentrations were slightly higher in PCOS subjects and correlated directly with HOMA-index and serum CRP, and inversely with HDL-cholesterol.…”

Section: European Journal Of Endocrinologymentioning

confidence: 99%

Plasma levels of pentraxin-3, an inflammatory protein involved in fertility, are reduced in women with polycystic ovary syndrome

Tosi

Sarra

Bonin

et al. 2014

European Journal of Endocrinology

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Objective: Pentraxin-3 (PTX3), like C-reactive protein (CRP), is an acute-phase protein that belongs to the pentraxin superfamily. Moreover, it is expressed in the cumulus oophorus and appears to be involved in female fertility. The aim of the present study was to assess whether PTX3 levels are altered in polycystic ovary syndrome (PCOS) women and whether they show any relationship with the main features of these subjects. Design: A cross-sectional study was conducted at the outpatient clinic of an academic centre. Methods: A total of 66 women affected with PCOS and 51 healthy controls were studied. Plasma PTX3 and serum CRP were measured by ELISA. Androgens were measured by liquid chromatography-mass spectrometry and free testosterone was measured by equilibrium dialysis. In PCOS women, insulin sensitivity was assessed by the glucose clamp technique. Results: Adjusting for age and BMI, plasma PTX3 was reduced in PCOS women (PZ0.036), in contrast with serum CRP, which was increased (PZ0.004). In multiple regression analysis, serum androgens and other endocrine and ovarian features of PCOS were predictors of PTX3 levels, whereas body fat was the main independent predictor of CRP concentrations. Conclusions: Plasma PTX3 levels were reduced in PCOS women and independently associated with hyperandrogenism and other endocrine and ovarian features of PCOS.

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High plasma level of long Pentraxin 3 is associated with insulin resistance in women with polycystic ovary syndrome

Abstract: PTX3 level is increased in patients with PCOS in concordance with insulin resistance.

Cited by 26 publications

References 23 publications

Is There Any Relationship between Plasma Pentraxin 3 Levels and Gestational Diabetes Mellitus?

Is There Any Relationship between Plasma Pentraxin 3 Levels and Gestational Diabetes Mellitus?

Is Pentraxin 3 a New Cardiovascular Risk Marker in Polycystic Ovary Syndrome?

Plasma levels of pentraxin-3, an inflammatory protein involved in fertility, are reduced in women with polycystic ovary syndrome

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