High Plasma Levels of MCP-1 and Eotaxin Provide Evidence for an Immunological Basis of Fibromyalgia

Zhang, Zhifang; Cherryholmes, Gregory; Mao, Allen; Marek, Claudia; Longmate, Jeffrey; Kalos, Michael; Amand, R. Paul St.; Shively, John E.

doi:10.3181/0712-rm-328

Cited by 65 publications

(115 citation statements)

References 44 publications

Supporting

Mentioning

104

Contrasting

Order By: Relevance

“…A study of 92 patients with fibromyalgia has shown that these patients have higher MCP-1 levels than controls and that their sera induce increased migration of macrophages. Interestingly, the levels of these cytokines did not differ when obese and non-obese patients with fibromyalgia were compared, a finding similar to the present study (35).…”

Section: Discussionsupporting

confidence: 79%

Serum levels of leptin and adiponectin and clinical parameters in women with fibromyalgia and overweight/obesity

Paiva

Andretta

Batista

et al. 2017

Arch. Endocrinol. Metab.

View full text Add to dashboard Cite

Objectives: The objectives of this study were to evaluate the serum levels of adipokines in women with fibromyalgia with and without overweight/obesity, and to correlate the adipokines levels with clinical parameters associated with fibromyalgia and adipose tissue mass (body fat). Subjects and methods: The study included 100 women divided into four groups: (a) fibromyalgia and overweight/obesity; (b) fibromyalgia and normal weight; (c) controls and overweight/obesity; and (d) controls and normal weight. Patients and controls were evaluated for clinical, anthropometric, and fibromyalgia-related parameters. Assessments included serum levels of leptin, adiponectin, monocyte chemoattractant protein-1 (MCP-1), and C-reactive protein (CRP). Levels of adipokines were further adjusted for fat mass. Results: Fibromyalgia patients with overweight/obesity or normal weight had no differences in clinical parameters. Unadjusted leptin levels were lower in fibromyalgia patients than controls, a finding that was more remarkable in fibromyalgia patients with overweight/obesity. Leptin levels had no correlation with clinical parameters of fibromyalgia or inflammation markers (MCP-1 and CRP), and adiponectin levels showed no difference between groups. Conclusions: No correlation was observed between adjusted leptin levels and clinical parameters of fibromyalgia. Patients with fibromyalgia and overweight/obesity presented lower levels of leptin than controls with overweight/ obesity. Arch Endocrinol Metab. 2017;61(3):249-56.

show abstract

Section: Discussionsupporting

confidence: 79%

Serum levels of leptin and adiponectin and clinical parameters in women with fibromyalgia and overweight/obesity

Paiva

Andretta

Batista

et al. 2017

Arch. Endocrinol. Metab.

View full text Add to dashboard Cite

show abstract

“…Monocyte chemoattractant protein-1 (MCP-1/CCL2) and eotaxin (CCL) have both been reported to be elevated in plasma of FMS patients (Zhang et al, 2008). MCP-1 also plays a pivotal role in inflammatory myopathies; myoblasts treated with MCP-1 or eotaxin secrete significant amounts of interleukin-1b (IL-1b) (Zhang et al, 2008).…”

Section: Pathogenesismentioning

confidence: 99%

“…MCP-1 also plays a pivotal role in inflammatory myopathies; myoblasts treated with MCP-1 or eotaxin secrete significant amounts of interleukin-1b (IL-1b) (Zhang et al, 2008). In addition, a study using a rat model to evaluate the involvement of MCP-1 in stress-induced chronic pain showed that MCP-1 induces longlasting muscle hyperalgesia and a state of latent chronic sensitization to other allogenic substances through activation of its high-affinity receptor, CCR2, located on the peripheral terminals of IB41 nociceptors (Alvarez et al, 2014).…”

Section: Pathogenesismentioning

confidence: 99%

Fibromyalgia Syndrome in Need of Effective Treatments

Theoharides

Tsilioni

Arbetman

et al. 2015

J Pharmacol Exp Ther

View full text Add to dashboard Cite

Fibromyalgia syndrome (FMS) is a chronic, idiopathic condition of widespread musculoskeletal pain, affecting primarily women. It is clinically characterized by chronic, nonarticular pain and a heightened response to pressure along with sleep disturbances, fatigue, bowel and bladder abnormalities, and cognitive dysfunction. The diagnostic criteria have changed repeatedly, and there is neither a definitive pathogenesis nor reliable diagnostic or prognostic biomarkers. Clinical and laboratory studies have provided evidence of altered central pain pathways. Recent evidence suggests the involvement of neuroinflammation with stress peptides triggering the release of neurosenzitizing mediators. The management of FMS requires a multidimensional approach including patient education, behavioral therapy, exercise, and pain management. Here we review recent data on the pathogenesis and propose new directions for research and treatment.

show abstract

“…The IL-8 has been found to be elevated in both serum and plasma of patients with FM [10,53,91,[97][98][99]100,106,107,111,113]. However, while most studies which studied the role of IL-8 in fibromyalgia, found it high, there are also authors who have not indicated variations of this inflammatory cytokine in the blood of patients with FM [102,105,110,112,114,115].…”

Section: Cytokines In Fmmentioning

confidence: 99%

Altered Inflammatory Mediators in Fibromyalgia

Garcı́a¹,

Carvajal-Gil²,

Herrero-Olea³

et al. 2017

Rheumatology

View full text Add to dashboard Cite

Fibromyalgia (FM) is a syndrome characterized by widespread chronic pain, tenderness, stiffness, fatigue, and sleep and mood disturbances. Current evidences suggest that inflammatory mediators may have an important role in the pathogenesis of fibromyalgia. Every day new evidences emerging of the role of the immune system and the inflammatory process in the pathophysiology of this disease. Thus, the aim of this work has been review that altered inductors, inflammatory mediators and effectors have been reported in fibromyalgia, and its relationship to disease's symptoms. If in fibromyalgia underlies widespread disruption of most characteristic components on the inflammatorý s process (endogenous inductors, mediators and effectors) is logical to think that fibromyalgia is producing a sustained inflammatory response in time, unregulated, responsible for the disease´s symptoms. Keywords:Fibromyalgia; Inflammation; HMGB1; Age; Inflammasome; Cytokines; Chemokines; Pentraxins; Lipid mediators; Monocytes; Neutrophils FibromyalgiaFibromyalgia (FM) is a chronic disease characterized by a widespread pain, tenderness, stiffness, fatigue, and sleep and mood disturbances. The prevalence of FM in the world ranges between 0.7% and 3.2%. It is more prevalent on women than men with a ratio women/men 20:1 (4.2% prevalence on women compared with 0.2% on men) [1] and it can develop at any age [2].The exact cause of fibromyalgia is unknown, but it has been proposed that the FM is a stress-related disorder that may involve a dysfunction of the hypothalamic-pituitary-adrenal axis (HPA) [3,4]. Thus, adverse life events, such as emotional, physical and sexual abuse on children and adults have been suggested to contribute to the development of FM [5][6][7].Risk factors FM have been the subject of much debate in recent research. There is no doubt that the experience of an abusive relationship, maintained over time, is a stressful situation that could be related to the presence of FM [8,9].Like all physiological systems, the immune system is under the control of the neuro-endocrine system and interacts and works in concert with other regulatory body systems, thus immune cells respond to neuroendocrine signals through specific receptors for hormones, neurotransmitters and neuropeptides. Therefore, dysregulation of the hypothalamic-pituitary-adrenal axis by chronic stress situations necessarily lead to a dysregulation of the immune function. Thus, inflammation is a characteristic process of the immune system, considered a defense response that is induced by infection or trauma. However, inflammation may also be induced by stress and tissue dysfunction in the absence of infection, there is a close relationship between body homeostasis, stress response and inflammation, since inflammation has both a component response to stress as a component defense response. Inflammation and FibromyalgiaIn 2001, Wallace et al. [10] were the first to suggest that inflammatory mediators, such as cytokines, could play a role in fibromyalgia. Prior results...

show abstract

High Plasma Levels of MCP-1 and Eotaxin Provide Evidence for an Immunological Basis of Fibromyalgia

Cited by 65 publications

References 44 publications

Serum levels of leptin and adiponectin and clinical parameters in women with fibromyalgia and overweight/obesity

Serum levels of leptin and adiponectin and clinical parameters in women with fibromyalgia and overweight/obesity

Fibromyalgia Syndrome in Need of Effective Treatments

Altered Inflammatory Mediators in Fibromyalgia

Contact Info

Product

Resources

About