High-Porosity Activated Carbons for Bilirubin Removal

Abstract

The aim of this study was to clarify the relationship between the extent of activation of synthetic granula and fibrous carbons and the adsorption of bilirubin from protein solutions. The total pore volumes of granular carbons START, SCN and fibrous activated carbons ACFM were 0.9–2.2. cm3/g and 0.8–1.5 cm3/g, respectively. A parallel increase in volume and specific surface area of micropores lead to a 4–5-fold increase of bilirubin adsorption from a 3% HS A solution. About 3 mg of bilirubin per 1 ml of the working column volume is removed from the solution with a 18 mg/100 ml concentration, after 8 min contact with an adsorbent after 4 hours of perfusion. Removal of bilirubin from model solutions means the conformation of albumin molecules can be restored. Carbon adsorbents synthesized for the elimination of bilirubin from protein-containing solutions can also be called deliganding adsorbents, since under some experimental conditions they eliminate other protein-bound ligands, viz. phenols by 97–99%, bile acids by 90–92% and sodium caprylate by 89–95%

Bilirubin and tryptophan adsorption in albumin-containing solutions

“…(7) and (8) in (1) leads to the following simplified expression of the free toxin fraction: (9) and the adsorption isotherm (6) can be rearranged in an apparent Langmuir isotherm in terms of total toxin concentration: (11) and…”

“…Bilirubin adsorption onto activated carbon has been studied in different liquid systems: chloroform-bilirubin (albumin-free) solutions [10], human serum albumin-bilirubin solutions [11][12][13], bovine serum albumin-bilirubin solutions [14] and human plasma [10]. Furthermore, Tsvetnov et al [15] and Ash et al [13] report some adsorption data of aromatic amino acids on ACs in aqueous solutions.…”

Biophysical Studies on the Correction of Uremic Human Serum Albumin Binding Defects by In Vitro Charcoal Adsorption Treatment

“…Adsorption treatment of these modified plasma samples was performed by outflow through a 10 cm3 microcolumn (height-to-diameter ratio of 7:2) containing 0.8 g of AUVM fibrous activated carbon (14) with a benzene pore volume of 0.75 cm3/g and a standard capacity for nonconjugated bilirubin of I .O mg/g. Adsorption treatment of these modified plasma samples was performed by outflow through a 10 cm3 microcolumn (height-to-diameter ratio of 7:2) containing 0.8 g of AUVM fibrous activated carbon (14) with a benzene pore volume of 0.75 cm3/g and a standard capacity for nonconjugated bilirubin of I .O mg/g.…”

Activating Carbon Fibers and Date Pits for Use in Liver Toxin Adsorption

“…Nikolaev et al [12] studied the efficiency of adsorbing bilirubin toxin of different types of AC. The different types of AC which were used in this research are Nitrogen based granular carbons, AC based on pyrolysis and fibrous AC.…”