High pre-therapy [99mTc]pertechnetate thyroid uptake, thyroid size and thyrostatic drugs: predictive factors of failure in [131I]iodide therapy in Graves' disease

Abstract

Fixed doses of 370 MBq of radioiodine seem to be practical and effective for treating Graves' disease patients with [99mTc]pertechnetate uptake <12.5% and thyroid mass <53 g. This treatment is clearly not recommended for patients with large goitre. In contrast to what could be expected, patients with a high pre-RIT thyroid uptake presented a higher rate of RIT failure.

High Failure Rates After 131I Therapy in Graves Hyperthyroidism Patients With Large Thyroid Volumes, High Iodine Uptake, and High Iodine Turnover

“…16,39,40 Furthermore, other factors, including gland uniformity and pretreatment with ATDs also affect outcome. 41 In our study, almost all our patients were pretreated with ATD, making it an unlikely factor for any differences in therapy outcome.…”

Radioiodine therapy in patients with Graves′ disease and the effects of prior carbimazole therapy

“…[1112] The good cure rates with low dose in our study population could be attributed due to relatively small diffused toxic goiters, probable relatively lesser iodine turnover, and persistent iodine-deficient state in a significant segment of Indian population despite universal iodization program implementation. Allahabadia et al ., reported that males are less likely to respond to a single dose of RAI[7] which is in line with study results in group B.…”

Factors Predicting Treatment Failure in Patients Treated with Iodine-131 for Graves′ disease

“…Similar results have also been reported by Zantut-Wittmann et al . [11] In a study by Allahabadia et al . which included 813 patients the authors concluded that male patients with large goiters are more likely not to respond to a single dose of 131 I even with high doses of 370 MBq and are concordant with our results.…”