The membrane–Fresnel diffractive lens (M-FDL) has great potential in the field of high-resolution and lightweight imaging in orbit. However, the M-FDL with high-optical quality and high-thermal stability cannot be fabricated to a standard by the existing processing methods. In this paper, we propose a method for fabricating an M-FDL composed of three steps: the improved repeated spin-coating of the polyimide (PI) membrane, the secondary mucosal method of silica-framed membrane mirror, and the high-precision fabrication of a multi-level microstructure on a flexible, ultrathin membrane substrate. The results show that the root mean square (RMS) of the wave-front error for M-FDL obtained by the above method is 1/28λ (F# = 8.7 at 632.8 nm) with an 80 mm clear aperture, the average diffraction efficiency is more than 70%, the silica-framed membrane mirror possesses approximately 40 times the overall thermal stability of the traditional metal-framed mirror, and the weight is less than 40 g. The measurement results indicate that the M-FDL has high-optical quality and high-thermal stability and can satisfy the imaging requirements.