High-precision K isotopic analysis of cerebrospinal fluid and blood serum microsamples via multicollector inductively coupled plasma-mass spectrometry equipped with 1013 Ω faraday cup amplifier resistors

Hobin, Kasper; Costas Rodríguez, Marta; Van Wonterghem, Elien; Vandenbroucke, Roosmarijn E.; Vanhaecke, Frank

doi:10.1016/j.aca.2024.342812

Analytica Chimica Acta

2024

DOI: 10.1016/j.aca.2024.342812

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High-precision K isotopic analysis of cerebrospinal fluid and blood serum microsamples via multicollector inductively coupled plasma-mass spectrometry equipped with 1013 Ω faraday cup amplifier resistors

Kasper Hobin,

Marta Costas Rodríguez,

Elien Van Wonterghem

et al.

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Stable potassium isotope ratios in human blood serum towards biomarker development in Alzheimer's disease

Mahan,

Hu,

Lahoud

et al. 2024

Metallomics

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The Alzheimer's disease (AD)-affected brain purges K with concurrently increasing serum K, suggesting brain–blood K transferal. Here, natural stable K isotope ratios—δ41K—of human serum samples were characterized in an AD biomarker pilot study (plus two paired Li-heparin and potassium ethylenediaminetetraacetic acid [K-EDTA] plasma samples). AD serum was found to have a significantly lower mean δ41K relative to controls. To mechanistically explore this change, novel ab initio calculations (density functional theory) of relative K isotope compositions between hydrated K+ and organically bound K were performed, identifying hydrated K+ as isotopically light (lower δ41K) compared to organically bound K. Taken together with literature, serum δ41K and density functional theory results are consistent with efflux of hydrated K+ from the brain to the bloodstream, manifesting a measurable decrease in serum δ41K. These data introduce serum δ41K for further investigation as a minimally invasive AD biomarker, with cost, scalability, and stability advantages over current techniques.

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Stable potassium isotope ratios in human blood serum towards biomarker development in Alzheimer's disease

Mahan,

Hu,

Lahoud

et al. 2024

Metallomics

View full text Add to dashboard Cite

show abstract

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High-precision K isotopic analysis of cerebrospinal fluid and blood serum microsamples via multicollector inductively coupled plasma-mass spectrometry equipped with 1013 Ω faraday cup amplifier resistors

Cited by 1 publication

References 34 publications

Stable potassium isotope ratios in human blood serum towards biomarker development in Alzheimer's disease

Stable potassium isotope ratios in human blood serum towards biomarker development in Alzheimer's disease

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