High precision patterning of biomaterials using the direct laser interference patterning technology

Günther, Denise; Scharnweber, Dieter; Hess, R. V.; Wolf‐Brandstetter, Cornelia; Holthaus, Marzellus Grosse; Lasagni, Andrés Fabían

doi:10.1016/b978-0-08-100883-6.00001-0

Cited by 15 publications

(8 citation statements)

References 92 publications

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“…Figure 4 summarizes the short-term adhesion test with S. epidermidis on PI. square millimeter to microlines and -pillars for different periods compared to the non-treated reference [31] .…”

Section: In Vitro Bacterial Analyses On Patterned Polymeric Samplesmentioning

confidence: 99%

Direct laser interference patterning for decreased bacterial attachment

et al. 2016

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In the past 15 years, many efforts were made to create functionalized artificial surfaces showing special anti-bacterial and anti-biofouling properties. Thereby, the topography of medical relevant materials plays an important role. However, the targeted fabrication of promising surface structures like hole-, lamella- and pyramid-like patterns with feature sizes in the sub-micrometer range in a one-step process is still a challenge. Optical and e-beam lithography, molding and selfassembly layers show a great potential to design topographies for this purpose. At the same time, most of these techniques are based on sequential processes, require masks or molds and thus are very device relevant and time consuming. In this work, we present the Direct Laser Interference Patterning (DLIP) technology as a capable method for the fast, flexible and direct fabrication of periodic micrometer- and submicrometer structures. This method offers the possibility to equip large plain areas and curved devices with 1D, 2D and 3D patterns. Simple 1D (e.g. lines) and complex 3D (e.g. lamella, pillars) patterns with periodic distances from 0.5 μm to 5 μm were fabricated on polymeric materials (polyimide, polystyrene). Subsequently, we characterized the adhesion behavior of Staphylococcus epidermidis and S. aureus bacteria under in vitro and in vivo conditions. The results revealed that the topographies have a significant impact on bacteria adhesion. On the one side, one-dimensional line-like structures especially with dimensions of the bacteria enhanced microbe attachment. While on the other hand, complex three-dimensional patterns prevented biofilm formation even after implantation and contamination in living organisms

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“…Figure 4 summarizes the short-term adhesion test with S. epidermidis on PI. square millimeter to microlines and -pillars for different periods compared to the non-treated reference [31] .…”

Section: In Vitro Bacterial Analyses On Patterned Polymeric Samplesmentioning

confidence: 99%

Direct laser interference patterning for decreased bacterial attachment

et al. 2016

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“…While microtopography (features size of <50 µm) aims to create structures with cellular, subcellular and macromolecular scale enhancing osseointegration, nanotopography (features size of <500 nm) covers the molecular and atomic scale, facilitating cell adhesion and mineral nucleation [14]. A combination of micro-and nano-scale features in implants seems to enhance bone regeneration [15,16]. The surface pattern direction also influences the cell growth orientation [17].…”

Section: Introductionmentioning

confidence: 99%

Direct Laser Interference Patterning of Bioceramics: A Short Review

et al. 2019

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Bioceramics are a great alternative to use in implants due to their excellent biocompatibility and good mechanical properties. Depending on their composition, bioceramics can be classified into bioinert and bioactive, which relate to their interaction with the surrounding living tissue. Surface morphology also has great influence on the implant biological behavior. Controlled texturing can improve osseointegration and reduce biofilm formation. Among the techniques to produce nano- and micropatterns, laser texturing has shown promising results due to its excellent accuracy and reproducibility. In this work, the use of laser techniques to improve surface morphology of biomaterials is reviewed, focusing on the application of direct laser interference patterning (DLIP) technique in bioceramics.

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“…Polyimide (PI) was textured using different laser wavelengths (λ = 1,064, 532, 355, and 266 nm) to avoid the biofilm formation on indwelling medical devices [105]. Several topographies were tested against Staphylococcus aureus adhesion.…”

Section: Other Polymersmentioning

confidence: 99%

Laser Surface Texturing of Polymers for Biomedical Applications

et al. 2018

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Polymers are materials widely used in biomedical science because of their biocompatibility, and good mechanical properties (which, in some cases, are similar to those of human tissues); however, these materials are, in general, chemically and biologically inert. Surface characteristics, such as topography (at the macro-, micro, and nano-scale), surface chemistry, surface energy, charge, or wettability are interrelated properties, and they cooperatively influence the biological performance of materials when used for biomedical applications. They regulate the biological response at the implant/tissue interface (e.g., influencing the cell adhesion, cell orientation, cell motility, etc.). Several surface processing techniques have been explored to modulate these properties for biomedical applications. Despite their potentials, these methods have limitations that prevent their applicability. In this regard, laser-based methods, in particular laser surface texturing (LST), can be an interesting alternative. Different works have showed the potentiality of this technique to control the surface properties of biomedical polymers and enhance their biological performance; however, more research is needed to obtain the desired biological response. This work provides a general overview of the basics and applications of LST for the surface modification of polymers currently used in the clinical practice (e.g., PEEK, UHMWPE, PP, etc.). The modification of roughness, wettability, and their impact on the biological response is addressed to offer new insights on the surface modification of biomedical polymers.

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High precision patterning of biomaterials using the direct laser interference patterning technology

Cited by 15 publications

References 92 publications

Direct laser interference patterning for decreased bacterial attachment

Direct laser interference patterning for decreased bacterial attachment

Direct Laser Interference Patterning of Bioceramics: A Short Review

Laser Surface Texturing of Polymers for Biomedical Applications

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