High prescribing rates of third-generation cephalosporins in children hospitalized with acute lower respiratory infections at a university hospital

Wacharachaisurapol, Noppadol; Jitrungruengnij, Nattapong; Janewongwirot, Pakpoom; Suchartlikitwong, Pintip; Chautrakarn, Sineenart; Jantarabenjakul, Watsamon; Anugulruengkitt, Suvaporn; Theerawit, Tuangtip; Sophonphan, Jiratchaya; Deerojanawong, Jitladda; Pancharoen, Chitsanu; Puthanakit, Thanyawee

doi:10.1016/j.ijid.2020.10.105

Cited by 3 publications

(2 citation statements)

References 24 publications

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“… 43 Among the drivers of ESBL production are overuse and misuse of third-generation cephalosporins in LMICs. 44 Unlike HIC which have robust antimicrobial stewardship programs, LMICs lack adequate antimicrobial surveillance mechanisms. 45 Dissemination of MDR strains including ESBL-PE negatively impacts patient outcomes by limiting therapeutic options available.…”

Section: Discussionmentioning

confidence: 99%

CTX-M, TEM, and SHV Genes in Escherichia coli, Klebsiella pneumoniae, and Enterobacter spp Isolated from Hematologic Cancer Patients with Bacteremia in Uganda

Lubwama,

Kateete,

Katende

et al. 2024

IDR

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Purpose We determined the phenotypic resistance to third-generation cephalosporins, phenotypic extended spectrum beta-lactamase (ESBL) prevalence, and genotypic prevalence of ESBL-encoding genes bla CTX-M , bla TEM , and bla SHV in Enterobacteriaceae isolated from hematologic cancer patients with febrile neutropenia and bacteremia at the Uganda Cancer Institute (UCI). Patients and Methods Blood cultures from hematologic cancer patients with febrile neutropenia were processed in BACTEC 9120. E. coli, K. pneumoniae, and Enterobacter spp . isolates were identified using conventional biochemical methods. Antimicrobial susceptibility tests, phenotypic ESBL characterization, and genotypic characterization of the ESBL-encoding genes bla CTX-M , bla TEM , and bla SHV were determined for pure isolates of E. coli, K. pneumoniae, and Enterobacter spp . Results Two hundred and two patients were included in the study. Median age of patients was 19 years (IQR: 10–30 years). Majority (N=119, 59%) were male patients. Sixty (30%) of the participants had at least one febrile episode due to Enterobacteriaceae. Eighty-three organisms were isolated with E. coli being predominant (45, 54%). Seventy-nine (95%) Enterobacteriaceae were multidrug resistant. The ESBL phenotype was detected in 54/73 (74%) of Enterobacteriaceae that were resistant to third-generation cephalosporins. A higher proportion of Enterobacteriaceae with ESBL-positive phenotype were resistant to piperacillin-tazobactam (p=0.024), gentamicin (p=0.000), ciprofloxacin (p=0.000), and cotrimoxazole (p=0.000) compared to Enterobacteriaceae, which were sensitive to third-generation cephalosporins. The organisms were more susceptible to carbapenems and chloramphenicol than resistant. ESBL-encoding genes ( bla CTX-M , bla TEM , and bla SHV ) were detected in 55 (75%) of the 73 Enterobacteriaceae that were resistant to third-generation cephalosporins. Bla CTX-M , was the most common ESBL-encoding gene identified with 50 (91%). Conclusion ESBL-producing Enterobacteriaceae are a predominant cause of bacteremia in hematologic cancer patients at UCI. The most common ESBL-encoding gene identified in the ESBL-PE was bla CTX-M . Resistance to imipenem and meropenem was low.

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Section: Discussionmentioning

confidence: 99%

CTX-M, TEM, and SHV Genes in Escherichia coli, Klebsiella pneumoniae, and Enterobacter spp Isolated from Hematologic Cancer Patients with Bacteremia in Uganda

Lubwama,

Kateete,

Katende

et al. 2024

IDR

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“…Due to their low toxicity and high therapeutic efficacy [7], they are a crucial antibiotic category. Cephalosporins are the most widely prescribed antibiotics worldwide, with numerous studies showing their broad-spectrum activity and potent bactericidal effect [8][9][10]. In livestock farming, they are used to treat bacterial infections in pigs, cattle, sheep, and poultry [11].…”

Section: Introductionmentioning

confidence: 99%

Assessment of the Impact of Ceftriaxone on the Functional Profile of Soil Microbiota Using Biolog EcoPlateTM

et al. 2023

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Background: Antibiotics are essential to the treatment of diseases, but they have also brought about concerns in terms of their environmental, economic, and health impacts. Antibiotics can be excreted in unchanged form or as metabolites, which can cause toxicity by contaminating different environmental compartments, including soil. Soil is a critical compartment due to the numerous functions it performs and its direct impact on the communities of microorganisms, plants, and animals that make up the soil ecosystem. The functional profile of soil microbiota has emerged as a promising tool to assess soil quality. This study aimed to evaluate the functional profile of soil microbiota and the gut microbiota of earthworms in ceftriaxone-contaminated soil using Biolog EcoPlate. Methods: Soil samples contaminated with varying concentrations of ceftriaxone (0, 1, and 10 mg/kg) were incubated for 14 days in the presence or absence of the earthworm Eisenia andrei. After exposure, the physiological profile of the soil microbiota and the gut microbiota of the earthworms were evaluated using Biolog EcoPlate. Results: No significant differences were observed in the parameters evaluated using different concentrations of the antibiotic. The functional profile of the microbiota in the soil with and without earthworms was found to be similar, but interestingly, it differed from the profile of the intestinal microbiota of the earthworms. Conclusion: The findings of this study indicate that the presence of earthworms did not significantly alter the functional profile of the soil microbiota in ceftriaxone-contaminated soil. Further studies are necessary to investigate the potential impact of ceftriaxone and other antibiotics on soil microbiota and the role of earthworms in this regard.

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An investigation of algal peptides to target protein of lower respiratory tract infections: In silico approach

Sathya¹,

Irfan²,

Badar³

et al. 2023

Biocatalysis and Agricultural Biotechnology

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High prescribing rates of third-generation cephalosporins in children hospitalized with acute lower respiratory infections at a university hospital

Cited by 3 publications

References 24 publications

CTX-M, TEM, and SHV Genes in Escherichia coli, Klebsiella pneumoniae, and Enterobacter spp Isolated from Hematologic Cancer Patients with Bacteremia in Uganda

CTX-M, TEM, and SHV Genes in Escherichia coli, Klebsiella pneumoniae, and Enterobacter spp Isolated from Hematologic Cancer Patients with Bacteremia in Uganda

Assessment of the Impact of Ceftriaxone on the Functional Profile of Soil Microbiota Using Biolog EcoPlateTM

An investigation of algal peptides to target protein of lower respiratory tract infections: In silico approach

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