High-pressure crystal polymorphs and multiple pathways in 1-hexyl-3-methylimidazolium perfluorobutanesulfonate ionic liquid

Abe, Hiroshi; Koyama, Yoshihiro; Shimono, Seiya; Kishimura, Hiroaki; Matsuishi, Kiyoto

doi:10.1016/j.chemphys.2022.111479

Cited by 8 publications

(1 citation statement)

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“…However, despite the oral delivery potential in comparison with other routes, the oral absorption mechanism of drugs is more complex and requires adequate solubility and stability values in the different portions of the gastrointestinal tract, as well as appropriate dissolution profiles [3]. Furthermore, the numerous structural possibilities of a particular active pharmaceutical ingredient (API) in the solid state, as well as several pharmaceutical production parameters, can have a considerable impact on its chemical, physical, and biopharmaceutical properties [1,5].…”

Section: Introductionmentioning

confidence: 99%

Pharmaceutical Crystals: Development, Optimization, Characterization and Biopharmaceutical Aspects

Bongioanni¹,

Bueno²,

Mezzano³

et al. 2023

Crystal Growth and Chirality - Technologies and Applications

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In the solid state, the active pharmaceutical ingredients tend to exhibit crystalline order. In this regard, the interest in the crystalline solid state has expanded to include single-component compounds as well as multicomponent systems such as salts, hydrates, solvates, and co-crystals. The study of crystalline behavior is recognized as an essential component of preformulation research in pharmaceutical sciences and industries. The crystalline form can impact the drug properties such as solubility, dissolution rate, stability, hygroscopicity, and toxicity profile. Therefore, each solid form must be appropriately identified and characterized because it will affect the drug formulation, including the pharmacokinetic, pharmacodynamic, and safety properties of the formulation. In this context, this chapter will cover topics such as synthesis approaches (including nucleation and crystallization procedures), crystal polymorphism, solid state characterization techniques and the impact of crystals on physicochemical and biopharmaceutical properties.

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Section: Introductionmentioning

confidence: 99%