High Pressure, Diazepam and pH Influences on Ketamine Anaesthesia in the Rat

35S-thiopental 15 mg/kg and 14C-diazepam 5 mg/kg were injected intravenously in separate groups of rats (n = 6) at 1 ATA air and at 71 ATA air-He. Total radioactivity was measured in the brain, liver, kidney, muscle and fat after 1, 3, 5 and 15 min. The thiopental content was significantly reduced at pressure in the brain at 3, 5 and 15 min. The diazepam content of the brain was significantly reduced at pressure at 1, 5 and 15 min. The liver, muscle and kidney tissue generally contained slightly less of either drug at pressure, particularly at the earliest sampling times.

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High Pressure, Diazepam and pH Influences on Ketamine Anaesthesia in the Rat

Cited by 3 publications

References 8 publications

Effets de l'acidose sur l'action des médicaments utilisés en anesthésie-réanimation

Effets de l'acidose sur l'action des médicaments utilisés en anesthésie-réanimation

Diazepam Under Hyperbaric Conditions in Rats

Tissue Distribution of Thiopental and Diazepam in Rats at 71 Atmospheres Pressure

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